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slco1c1 solute carrier organic anion transporter family, member 1C1 [ Danio rerio (zebrafish) ]

Gene ID: 562772, updated on 11-Apr-2024

Summary

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Official Symbol
slco1c1provided by ZNC
Official Full Name
solute carrier organic anion transporter family, member 1C1provided by ZNC
Primary source
ZFIN:ZDB-GENE-041210-50
See related
Ensembl:ENSDARG00000016749 AllianceGenome:ZFIN:ZDB-GENE-041210-50
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-217k21.8
Summary
Predicted to enable sodium-independent organic anion transmembrane transporter activity. Predicted to be involved in sodium-independent organic anion transport. Predicted to act upstream of or within ion transport and transmembrane transport. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in brain. Human ortholog(s) of this gene implicated in bilirubin metabolic disorder. Orthologous to several human genes including SLCO1C1 (solute carrier organic anion transporter family member 1C1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 4
Exon count:
17
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (2674761..2745425, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (2744240..2815312, complement)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene dihydrouridine synthase 4-like (S. cerevisiae) Neighboring gene B cell receptor associated protein 29 Neighboring gene phosphodiesterase 3A, cGMP-inhibited Neighboring gene AE binding protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Tsh Induces Agrp1 Neuron Proliferation in Oatp1c1-Deficient Zebrafish. Wasserman-Bartov T, et al. J Neurosci, 2022 Nov 2. PMID 36150888, Free PMC Article
  2. Behavioral, morphometric, and gene expression effects in adult zebrafish (Danio rerio) embryonically exposed to PFOA, PFOS, and PFNA. Jantzen CE, et al. Aquat Toxicol, 2016 Nov. PMID 27710860, Free PMC Article
  3. Organic anion transporting polypeptides of the OATP/SLCO superfamily: identification of new members in nonmammalian species, comparative modeling and a potential transport mode. Meier-Abt F, et al. J Membr Biol, 2005 Dec. PMID 16648940
  4. Zebrafish Oatp-mediated transport of microcystin congeners. Steiner K, et al. Arch Toxicol, 2016 May. PMID 26055554, Free PMC Article
  5. Knockdown of monocarboxylate transporter 8 (mct8) disturbs brain development and locomotion in zebrafish. de Vrieze E, et al. Endocrinology, 2014 Jun. PMID 24693966

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tsh Induces Agrp1 Neuron Proliferation in Oatp1c1-Deficient Zebrafish.
    Title: Tsh Induces Agrp1 Neuron Proliferation in Oatp1c1-Deficient Zebrafish.
  2. Neural Alterations and Hyperactivity of the Hypothalamic-Pituitary-Thyroid Axis in Oatp1c1 Deficiency.
    Title: Neural Alterations and Hyperactivity of the Hypothalamic-Pituitary-Thyroid Axis in Oatp1c1 Deficiency.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables sodium-independent organic anion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium-independent organic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
solute carrier organic anion transporter family member 1C1
Names
oatp1c1
zOatp1c3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044997.3 → NP_001038462.2  solute carrier organic anion transporter family member 1C1

    Status: PROVISIONAL

    Source sequence(s)
    BX072538, BX323818, CT009595
    UniProtKB/TrEMBL
    A0A8M1N9T5, Q5RIX3
    Related
    ENSDARP00000147503.1, ENSDART00000184693.1
    Conserved Domains (3) summary
    cd06174
    Location:50 → 461
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:470 → 523
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:48 → 631
    OATP; Organic Anion Transporter Polypeptide (OATP) family

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    2674761..2745425 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009299973.3 → XP_009298248.1  solute carrier organic anion transporter family member 1C1 isoform X1

    See identical proteins and their annotated locations for XP_009298248.1

    UniProtKB/TrEMBL
    A0A8M2BBX6, B3DJD4
    Conserved Domains (3) summary
    cd06174
    Location:50 → 461
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:470 → 523
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:48 → 631
    OATP; Organic Anion Transporter Polypeptide (OATP) family

  2. XM_005164471.4 → XP_005164528.1  solute carrier organic anion transporter family member 1C1 isoform X1

    See identical proteins and their annotated locations for XP_005164528.1

    UniProtKB/TrEMBL
    A0A8M2BBX6, B3DJD4
    Related
    ENSDARP00000039385.6, ENSDART00000039083.9
    Conserved Domains (3) summary
    cd06174
    Location:50 → 461
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:470 → 523
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:48 → 631
    OATP; Organic Anion Transporter Polypeptide (OATP) family

  3. XM_009299972.3 → XP_009298247.1  solute carrier organic anion transporter family member 1C1 isoform X1

    See identical proteins and their annotated locations for XP_009298247.1

    UniProtKB/TrEMBL
    A0A8M2BBX6, B3DJD4
    Conserved Domains (3) summary
    cd06174
    Location:50 → 461
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:470 → 523
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:48 → 631
    OATP; Organic Anion Transporter Polypeptide (OATP) family

  4. XM_009299975.3 → XP_009298250.1  solute carrier organic anion transporter family member 1C1 isoform X2

    UniProtKB/TrEMBL
    A0A8M3B8P6
    Conserved Domains (3) summary
    cd06174
    Location:50 → 461
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:470 → 523
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:48 → 631
    OATP; Organic Anion Transporter Polypeptide (OATP) family
Nucleotide Protein
Heading Accession and Version

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