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Atl2 atlastin GTPase 2 [ Mus musculus (house mouse) ]

Gene ID: 56298, updated on 11-Apr-2024

Summary

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Official Symbol
Atl2provided by MGI
Official Full Name
atlastin GTPase 2provided by MGI
Primary source
MGI:MGI:1929492
See related
Ensembl:ENSMUSG00000059811 AllianceGenome:MGI:1929492
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Aip-2; Arl6ip2; 2010110I21Rik
Summary
Predicted to enable GTP binding activity; GTPase activity; and identical protein binding activity. Predicted to be involved in Golgi organization; endoplasmic reticulum tubular network membrane organization; and protein homooligomerization. Predicted to be located in endoplasmic reticulum tubular network membrane. Predicted to be integral component of membrane. Is expressed in several structures, including alimentary system; ganglia; genitourinary system; nasal cavity epithelium; and skin. Orthologous to human ATL2 (atlastin GTPase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 8.7), thymus adult (RPKM 7.2) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Atl2 in Genome Data Viewer
Location:
17 E3; 17 50.3 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (80155819..80203633, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (79848352..79896204, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43287 Neighboring gene predicted gene, 33055 Neighboring gene predicted gene, 49984 Neighboring gene STARR-seq mESC enhancer starr_43288 Neighboring gene STARR-positive B cell enhancer ABC_E9444 Neighboring gene predicted gene, 41625 Neighboring gene STARR-seq mESC enhancer starr_43290 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:80354198-80354418 Neighboring gene eukaryotic translation initiation factor 3, subunit H pseudogene Neighboring gene STARR-seq mESC enhancer starr_43292 Neighboring gene STARR-positive B cell enhancer mm9_chr17:80381942-80382243 Neighboring gene STARR-positive B cell enhancer ABC_E4228 Neighboring gene STARR-seq mESC enhancer starr_43295 Neighboring gene heterogeneous nuclear ribonucleoprotein L-like Neighboring gene predicted gene, 22215

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Defects of the endoplasmic reticulum and changes to lipid droplet size in mammary epithelial cells due to miR-30b-5p overexpression are correlated to a reduction in Atlastin 2 expression. Le Guillou S, et al. Biochem Biophys Res Commun, 2019 Apr 30. PMID 30879769
  2. Mammalian knock out cells reveal prominent roles for atlastin GTPases in ER network morphology. Zhao G, et al. Exp Cell Res, 2016 Nov 15. PMID 27669642
  3. A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit. Ingley E, et al. FEBS Lett, 1999 Oct 1. PMID 10508919
  4. Differential gene expression in the distal tip endoderm of the embryonic mouse lung. Liu Y, et al. Gene Expr Patterns, 2002 Dec. PMID 12617806
  5. Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death. Sellier C, et al. EMBO J, 2016 Jun 15. PMID 27103069, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the increase in lipid droplet size observed in the mammary epithelial cells of transgenic mice might result from changes to lipid droplet formation and secretion because of direct modifications to Atl2 expression and indirect changes to endoplasmic reticulum morphology resulting from the overexpression of miR-30b-5p
    Title: Defects of the endoplasmic reticulum and changes to lipid droplet size in mammary epithelial cells due to miR-30b-5p overexpression are correlated to a reduction in Atlastin 2 expression.
  2. Endoplasmic reticulum morphology is markedly disrupted in ATL1, ATL2, and ATL3 knockout cells.
    Title: Mammalian knock out cells reveal prominent roles for atlastin GTPases in ER network morphology.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi organization ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum organization ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum tubular network membrane organization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein homooligomerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein homooligomerization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum tubular network membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
atlastin-2
Names
ADP-ribosylation factor-like 6 interacting protein 2
ADP-ribosylation factor-like protein 6-interacting protein 2
ADP-ribosylation-like factor 6 interacting protein 2
ARL-6 interacting protein-2
NP_001273576.1
NP_001344681.1
NP_001344682.1
NP_062691.3
NP_835151.2
XP_006524718.1
XP_036016582.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286647.1 → NP_001273576.1  atlastin-2 isoform 3

    See identical proteins and their annotated locations for NP_001273576.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences, compared to variant 1. These differences result in an additional internal 5' UTR segment, translation initiation at a downstream start codon, and an alternate 3' coding region, compared to variant 1. The encoded protein (isoform 3) has a shorter N-terminus and a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK008381, AK032050, AK038697, BM938279, BY244533
    UniProtKB/TrEMBL
    Q8BYP9
    Conserved Domains (1) summary
    cl21455
    Location:1 → 170
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_001357752.1 → NP_001344681.1  atlastin-2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC117261, BM938279
    Conserved Domains (1) summary
    pfam02263
    Location:70 → 341
    GBP; Guanylate-binding protein, N-terminal domain

  3. NM_001357753.1 → NP_001344682.1  atlastin-2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC117261, BM938279
    Conserved Domains (1) summary
    pfam02263
    Location:70 → 341
    GBP; Guanylate-binding protein, N-terminal domain

  4. NM_019717.3 → NP_062691.3  atlastin-2 isoform 1

    See identical proteins and their annotated locations for NP_062691.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK008381, AK032050, AK038697, BC060501, BM938279
    Consensus CDS
    CCDS37700.1
    UniProtKB/Swiss-Prot
    Q3UX01, Q6PA06, Q7TMM3
    Related
    ENSMUSP00000064758.6, ENSMUST00000068282.7
    Conserved Domains (1) summary
    pfam02263
    Location:70 → 341
    GBP; Guanylate-binding protein, N-terminal domain

  5. NM_178050.4 → NP_835151.2  atlastin-2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal exon in the 5' region, which results in translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK008381, AK032050, AK038697, AK135988, BC060501, BM938279
    Consensus CDS
    CCDS37701.1
    UniProtKB/TrEMBL
    E9QND8
    Related
    ENSMUSP00000108056.2, ENSMUST00000112437.8
    Conserved Domains (1) summary
    cl21455
    Location:1 → 170
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    80155819..80203633 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160689.1 → XP_036016582.1  atlastin-2 isoform X2

    Conserved Domains (1) summary
    pfam02263
    Location:16 → 287
    GBP; Guanylate-binding protein, N-terminal domain

  2. XM_006524655.5 → XP_006524718.1  atlastin-2 isoform X1

    Conserved Domains (1) summary
    pfam02263
    Location:70 → 341
    GBP; Guanylate-binding protein, N-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PA06.1 GenPept UniProtKB/Swiss-Prot:Q6PA06

Gene LinkOut

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