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Metap2 methionine aminopeptidase 2 [ Mus musculus (house mouse) ]

Gene ID: 56307, updated on 23-Jun-2021

Summary

Official Symbol
Metap2provided by MGI
Official Full Name
methionine aminopeptidase 2provided by MGI
Primary source
MGI:MGI:1929701
See related
Ensembl:ENSMUSG00000036112
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p6; p67; Amp2; Mnpep; p67eIF2; AI047573; AL024412; AU014659; 4930584B20Rik; A930035J23Rik
Expression
Broad expression in liver E14 (RPKM 47.5), liver E14.5 (RPKM 37.1) and 20 other tissues See more
Orthologs
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Genomic context

See Metap2 in Genome Data Viewer
Location:
10; 10 C2
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (93694351..93732952, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (93858489..93897090, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (93321234..93353947, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene farnesyl diphosphate synthetase pseudogene Neighboring gene predicted gene, 26239 Neighboring gene ubiquitin specific peptidase 44 Neighboring gene microRNA 331 Neighboring gene vezatin, adherens junctions transmembrane protein Neighboring gene mitochondrial inner membrane protease subunit 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC102452

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aminopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloaminopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables metalloexopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in N-terminal protein amino acid modification ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-methionine modification ISO
Inferred from Sequence Orthology
more info
 
involved_in protein processing ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
methionine aminopeptidase 2
Names
MAP 2
eIF-2-associated p67
initiation factor 2-associated 67 kDa glycoprotein
initiation factor 2-associated protein (p67)
metAP 2
peptidase M 2
NP_062622.1
XP_006513959.1
XP_006513960.1
XP_017169521.1
XP_036011787.1
XP_036011788.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019648.3NP_062622.1  methionine aminopeptidase 2

    See identical proteins and their annotated locations for NP_062622.1

    Status: VALIDATED

    Source sequence(s)
    AC124686, AF434712, AK165301
    Consensus CDS
    CCDS48673.1
    UniProtKB/Swiss-Prot
    O08663
    UniProtKB/TrEMBL
    Q58E65
    Related
    ENSMUSP00000138006.2, ENSMUST00000180840.8
    Conserved Domains (1) summary
    PTZ00053
    Location:107478
    PTZ00053; methionine aminopeptidase 2; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    93694351..93732952 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513896.4XP_006513959.1  methionine aminopeptidase 2 isoform X1

    See identical proteins and their annotated locations for XP_006513959.1

    UniProtKB/Swiss-Prot
    O08663
    UniProtKB/TrEMBL
    Q58E65
    Conserved Domains (1) summary
    PTZ00053
    Location:107478
    PTZ00053; methionine aminopeptidase 2; Provisional
  2. XM_017314032.2XP_017169521.1  methionine aminopeptidase 2 isoform X2

    Conserved Domains (1) summary
    PTZ00053
    Location:106477
    PTZ00053; methionine aminopeptidase 2; Provisional
  3. XM_006513897.5XP_006513960.1  methionine aminopeptidase 2 isoform X1

    See identical proteins and their annotated locations for XP_006513960.1

    UniProtKB/Swiss-Prot
    O08663
    UniProtKB/TrEMBL
    Q58E65
    Related
    ENSMUSP00000138083.2, ENSMUST00000181217.8
    Conserved Domains (1) summary
    PTZ00053
    Location:107478
    PTZ00053; methionine aminopeptidase 2; Provisional
  4. XM_036155894.1XP_036011787.1  methionine aminopeptidase 2 isoform X1

    Conserved Domains (1) summary
    PTZ00053
    Location:107478
    PTZ00053; methionine aminopeptidase 2; Provisional
  5. XM_036155895.1XP_036011788.1  methionine aminopeptidase 2 isoform X2

    Conserved Domains (1) summary
    PTZ00053
    Location:106477
    PTZ00053; methionine aminopeptidase 2; Provisional
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