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Dbn1 drebrin 1 [ Mus musculus (house mouse) ]

Gene ID: 56320, updated on 5-Sep-2021

Summary

Official Symbol
Dbn1provided by MGI
Official Full Name
drebrin 1provided by MGI
Primary source
MGI:MGI:1931838
See related
Ensembl:ENSMUSG00000034675
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Expression
Biased expression in whole brain E14.5 (RPKM 193.5), CNS E14 (RPKM 184.8) and 14 other tissues See more
Orthologs
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Genomic context

See Dbn1 in Genome Data Viewer
Location:
13 B1; 13 30.06 cM
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (55621241..55635959, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (55473428..55488126, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (55574789..55589437, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor kinase 6 Neighboring gene microRNA 6943 Neighboring gene proline rich 7 (synaptic) Neighboring gene microRNA 6944 Neighboring gene PDZ and LIM domain 7 Neighboring gene microRNA 6945 Neighboring gene docking protein 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
 
enables cytoskeletal motor inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables cytoskeletal protein binding ISO
Inferred from Sequence Orthology
more info
 
enables profilin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within actin filament organization IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cell communication by chemical coupling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell communication by electrical coupling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to transforming growth factor beta stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
involved_in cytoplasmic sequestering of protein ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within generation of neurons IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within maintenance of protein location in cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in modulation of inhibitory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of actin filament bundle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of locomotion involved in locomotory behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of muscle filament sliding ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neural precursor cell proliferation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of axon extension IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of axon extension ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dendritic spine morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of dendritic spine morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor localization to synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in postsynaptic actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in postsynaptic actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in prepulse inhibition ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of filopodium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of postsynaptic density protein 95 clustering ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with actin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with actin filament ISO
Inferred from Sequence Orthology
more info
 
located_in asymmetric synapse ISO
Inferred from Sequence Orthology
more info
 
located_in axonal growth cone ISO
Inferred from Sequence Orthology
more info
 
located_in axonal spine ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
is_active_in cortical actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic filopodium ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic shaft ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
located_in excitatory synapse ISO
Inferred from Sequence Orthology
more info
 
located_in filopodium ISO
Inferred from Sequence Orthology
more info
 
located_in gap junction IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in growth cone IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron spine ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in site of polarized growth IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
drebrin
Names
developmentally-regulated brain protein
drebrin A
drebrin E2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177371.1NP_001170842.1  drebrin isoform 1

    See identical proteins and their annotated locations for NP_001170842.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    CT009762
    Consensus CDS
    CCDS49274.1
    UniProtKB/Swiss-Prot
    Q9QXS6
    Related
    ENSMUSP00000021950.9, ENSMUST00000021950.15
    Conserved Domains (1) summary
    cd11281
    Location:4139
    ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
  2. NM_001177372.1NP_001170843.1  drebrin isoform 2

    See identical proteins and their annotated locations for NP_001170843.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon and uses an alternate in-frame splice site, compared to variant 1. The resulting isoform (2) differs in two regions, compared to isoform 1.
    Source sequence(s)
    AK132060, BY255065, CT009762
    Consensus CDS
    CCDS49273.1
    UniProtKB/Swiss-Prot
    Q9QXS6
    UniProtKB/TrEMBL
    A0A0R4J1E3
    Related
    ENSMUSP00000105547.3, ENSMUST00000109921.9
    Conserved Domains (1) summary
    cd11281
    Location:4139
    ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
  3. NM_019813.4NP_062787.2  drebrin isoform 3

    See identical proteins and their annotated locations for NP_062787.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The resulting isoform (3) lacks an alternate segment, compared to isoform 1.
    Source sequence(s)
    AK162697, BY255065, CT009762
    Consensus CDS
    CCDS36677.1
    UniProtKB/Swiss-Prot
    Q9QXS6
    UniProtKB/TrEMBL
    Q3TRK3
    Related
    ENSMUSP00000105549.3, ENSMUST00000109923.9
    Conserved Domains (1) summary
    cd11281
    Location:4139
    ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    55621241..55635959 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517305.5XP_006517368.1  drebrin isoform X1

    Conserved Domains (1) summary
    cd11281
    Location:4139
    ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
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