U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Timm22 translocase of inner mitochondrial membrane 22 [ Mus musculus (house mouse) ]

Gene ID: 56322, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Timm22provided by MGI
Official Full Name
translocase of inner mitochondrial membrane 22provided by MGI
Primary source
MGI:MGI:1929742
See related
Ensembl:ENSMUSG00000020843 AllianceGenome:MGI:1929742
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tim22
Summary
Predicted to enable mitochondrion targeting sequence binding activity and protein transmembrane transporter activity. Predicted to be involved in protein insertion into mitochondrial inner membrane. Predicted to act upstream of or within protein transport. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; cardiovascular system; egg cylinder; and genitourinary system. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 43. Orthologous to human TIMM22 (translocase of inner mitochondrial membrane 22). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 6.6), CNS E11.5 (RPKM 6.4) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
11 B5; 11 45.92 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (76297751..76307139)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (76406925..76416313)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7019 Neighboring gene mitochondrial rRNA methyltransferase 3 Neighboring gene nucleoredoxin Neighboring gene STARR-seq mESC enhancer starr_30020 Neighboring gene STARR-seq mESC enhancer starr_30022 Neighboring gene STARR-seq mESC enhancer starr_30023 Neighboring gene STARR-seq mESC enhancer starr_30026 Neighboring gene STARR-positive B cell enhancer ABC_E9828 Neighboring gene STARR-positive B cell enhancer ABC_E3976 Neighboring gene STARR-positive B cell enhancer ABC_E7020 Neighboring gene active BCR-related gene Neighboring gene STARR-seq mESC enhancer starr_30035 Neighboring gene predicted gene 12341 Neighboring gene STARR-seq mESC enhancer starr_30037 Neighboring gene predicted gene, 53687

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. New testis-specific expressed genes on mouse Chromosome 11. Voss GC, et al. Mamm Genome, 1996 Feb. PMID 8835539
  2. The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom. Bauer MF, et al. FEBS Lett, 1999 Dec 24. PMID 10611480
  3. Nuclear-encoded mitochondrial ribosomal proteins are required to initiate gastrulation. Cheong A, et al. Development, 2020 May 26. PMID 32376682, Free PMC Article
  4. RONIN Is an Essential Transcriptional Regulator of Genes Required for Mitochondrial Function in the Developing Retina. Poché RA, et al. Cell Rep, 2016 Feb 23. PMID 26876175, Free PMC Article
  5. Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. Sundberg JP, et al. PLoS One, 2017. PMID 28700664, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

Go to the top of the page Help

Homology

Clone Names

  • 2610511O07Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mitochondrion targeting sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein insertion into mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein insertion into mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of TIM22 mitochondrial import inner membrane insertion complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TIM22 mitochondrial import inner membrane insertion complex ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 

General protein information

Go to the top of the page Help
Preferred Names
mitochondrial import inner membrane translocase subunit Tim22
Names
preprotein translocase
translocase of inner mitochondrial membrane 22 homolog

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291161.1 → NP_001278090.1  mitochondrial import inner membrane translocase subunit Tim22 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks part of the 5' coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform (3) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK012130, BB724262, CA751902, CN710089
    Consensus CDS
    CCDS70245.1
    UniProtKB/TrEMBL
    B0QZS8
    Related
    ENSMUSP00000113238.2, ENSMUST00000120699.8
    Conserved Domains (1) summary
    pfam02466
    Location:22 → 131
    Tim17; Tim17/Tim22/Tim23/Pmp24 family

  2. NM_019818.5 → NP_062792.2  mitochondrial import inner membrane translocase subunit Tim22 isoform 1

    See identical proteins and their annotated locations for NP_062792.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest isoform (1).
    Source sequence(s)
    AK012130, BB724262, BY309364
    Consensus CDS
    CCDS25065.1
    UniProtKB/Swiss-Prot
    Q5SSL1, Q5SSL2, Q8QZU2, Q9CQ85, Q9JKW2
    Related
    ENSMUSP00000021203.7, ENSMUST00000021203.7
    Conserved Domains (1) summary
    pfam02466
    Location:69 → 186
    Tim17; Tim17/Tim22/Tim23/Pmp24 family

  3. NM_023355.2 → NP_075844.1  mitochondrial import inner membrane translocase subunit Tim22 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) is missing an exon in the coding region compared to transcript variant 1, which results in a frame-shift and a shorter isoform (2) with a distinct C-terminus compared to isoform 1. Variant 2 has transcript support, but the encoded isoform 2 is predicted, lacking in vivo protein support.
    Source sequence(s)
    AK012130, BB724262, BY309364
    UniProtKB/Swiss-Prot
    Q9CQ85

RNA

  1. NR_111896.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate 5'terminal exon and an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AK012130, BB724262, CA751902, CN710089

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    76297751..76307139
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQ85.1 GenPept UniProtKB/Swiss-Prot:Q9CQ85

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous