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Ptges3 prostaglandin E synthase 3 [ Mus musculus (house mouse) ]

Gene ID: 56351, updated on 23-Jun-2021

Summary

Official Symbol
Ptges3provided by MGI
Official Full Name
prostaglandin E synthase 3provided by MGI
Primary source
MGI:MGI:1929282
See related
Ensembl:ENSMUSG00000071072
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ptg; Teb; cPG; p23; Tebp; Ptges; cPGES; sid31; sid3177; 5730442A20Rik
Expression
Ubiquitous expression in CNS E11.5 (RPKM 32.9), adrenal adult (RPKM 31.2) and 28 other tissues See more
Orthologs
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Genomic context

See Ptges3 in Genome Data Viewer
Location:
10; 10 D3
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127894851..127913123)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128058982..128077254)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (127496038..127514310)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene DNA primase, p49 subunit Neighboring gene nascent polypeptide-associated complex alpha polypeptide Neighboring gene predicted gene, 47438 Neighboring gene small nucleolar RNA, C/D box 59A Neighboring gene ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit Neighboring gene microRNA 677

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA polymerase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables DNA polymerase binding ISO
Inferred from Sequence Orthology
more info
 
enables Hsp90 protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables Hsp90 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables p53 binding ISO
Inferred from Sequence Orthology
more info
 
enables prostaglandin-E synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables prostaglandin-E synthase activity ISO
Inferred from Sequence Orthology
more info
 
enables telomerase activity ISO
Inferred from Sequence Orthology
more info
 
enables unfolded protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chaperone cofactor-dependent protein refolding ISO
Inferred from Sequence Orthology
more info
 
involved_in chaperone-mediated protein complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chaperone-mediated protein complex assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within glucocorticoid receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glycogen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lung saccule development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of telomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of telomerase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in prostaglandin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within prostaglandin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in prostaglandin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in prostaglandin metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within skin development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in telomerase holoenzyme complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in telomerase holoenzyme complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in telomerase holoenzyme complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in telomere maintenance via telomerase IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in telomere maintenance via telomerase IDA
Inferred from Direct Assay
more info
PubMed 
involved_in telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in actin filament ISO
Inferred from Sequence Orthology
more info
 
part_of chaperone complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of telomerase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
prostaglandin E synthase 3
Names
cytosolic prostaglandin E2 synthase
hsp90 co-chaperone
p23 cochaperone
progesterone receptor complex p23
prostaglandin E synthase 3 (cytosolic)
sid 3177
telomerase binding protein, p23
NP_062740.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019766.4NP_062740.1  prostaglandin E synthase 3

    See identical proteins and their annotated locations for NP_062740.1

    Status: PROVISIONAL

    Source sequence(s)
    AC131120
    Consensus CDS
    CCDS36087.1
    UniProtKB/Swiss-Prot
    Q9R0Q7
    Related
    ENSMUSP00000050292.8, ENSMUST00000052798.14
    Conserved Domains (1) summary
    cd00237
    Location:3109
    p23; p23 binds heat shock protein (Hsp)90 and participates in the folding of a number of Hsp90 clients, including the progesterone receptor. p23 also has a passive chaperoning activity and in addition may participate in prostaglandin synthesis.

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    127894851..127913123
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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