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Acot9 acyl-CoA thioesterase 9 [ Mus musculus (house mouse) ]

Gene ID: 56360, updated on 22-Aug-2021

Summary

Official Symbol
Acot9provided by MGI
Official Full Name
acyl-CoA thioesterase 9provided by MGI
Primary source
MGI:MGI:1928939
See related
Ensembl:ENSMUSG00000025287
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
U8; p4; p48; Acat; MTE-2; Acate2; C76421; MT-ACT4; MT-ACT48; 0610041P13Rik
Expression
Ubiquitous expression in genital fat pad adult (RPKM 15.0), placenta adult (RPKM 10.3) and 27 other tissues See more
Orthologs
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Genomic context

See Acot9 in Genome Data Viewer
Location:
X; X F3
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (154045439..154080650)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (155262443..155297654)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (151697043..151732050)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene spermidine/spermine N1-acetyl transferase 1 Neighboring gene ribosomal protein L7 pseudogene Neighboring gene peroxiredoxin 4 Neighboring gene predicted gene, 39545 Neighboring gene small nucleolar RNA SNORA48

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetyl-CoA hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables acyl-CoA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables acyl-CoA hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables myristoyl-CoA hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables palmitoyl-CoA hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
acyl-coenzyme A thioesterase 9, mitochondrial
Names
acyl coenzyme A thioester hydrolase 2
acyl-CoA thioester hydrolase 9
acyl-Coenzyme A thioesterase 2, mitochondrial
mitochondrial 48 kDa acyl-CoA thioester hydrolase 1
mitochondrial acyl-CoA thioesterase
protein U8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313718.1NP_001300647.1  acyl-coenzyme A thioesterase 9, mitochondrial isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' end, which causes translation initiation at a downstream AUG and results in an isoform (2) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AI854821, AK076513, BY288219
    Conserved Domains (1) summary
    PLN02647
    Location:3336
    PLN02647; acyl-CoA thioesterase
  2. NM_019736.4NP_062710.2  acyl-coenzyme A thioesterase 9, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_062710.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AI854821, AK168713, BY288219
    Consensus CDS
    CCDS41187.1
    UniProtKB/Swiss-Prot
    Q9R0X4
    Related
    ENSMUSP00000026324.10, ENSMUST00000026324.10
    Conserved Domains (1) summary
    cd03442
    Location:286406
    BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    154045439..154080650
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251411.2XP_030107271.1  acyl-coenzyme A thioesterase 9, mitochondrial isoform X1

    Conserved Domains (1) summary
    PLN02647
    Location:3336
    PLN02647; acyl-CoA thioesterase
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