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Pus1 pseudouridine synthase 1 [ Mus musculus (house mouse) ]

Gene ID: 56361, updated on 23-Jun-2021

Summary

Official Symbol
Pus1provided by MGI
Official Full Name
pseudouridine synthase 1provided by MGI
Primary source
MGI:MGI:1929237
See related
Ensembl:ENSMUSG00000029507
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MPU; MPUS1; mPus1p; A730013B20Rik
Expression
Ubiquitous expression in large intestine adult (RPKM 13.1), liver E14 (RPKM 13.0) and 28 other tissues See more
Orthologs
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Genomic context

See Pus1 in Genome Data Viewer
Location:
5; 5 F
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (110921533..110928523, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (110773667..110780649, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (111202686..111209634, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene E1A binding protein p400 Neighboring gene predicted gene, 26079 Neighboring gene predicted gene, 22583 Neighboring gene predicted gene 15559 Neighboring gene unc-51 like kinase 1 Neighboring gene ES cell cis-regulatory motif 10b Neighboring gene HscB iron-sulfur cluster co-chaperone

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables nuclear receptor coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables pseudouridine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables pseudouridine synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables pseudouridine synthase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables pseudouridine synthase activity ISO
Inferred from Sequence Orthology
more info
 
enables steroid receptor RNA activator RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables tRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables tRNA pseudouridine synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA modification IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA pseudouridine synthesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mRNA pseudouridine synthesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in pseudouridine synthesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA pseudouridine synthesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within tRNA pseudouridine synthesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in tRNA pseudouridine synthesis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tRNA pseudouridine synthase A
Names
tRNA pseudouridine synthase A, mitochondrial
tRNA pseudouridine(38-40) synthase
tRNA pseudouridylate synthase I
tRNA-uridine isomerase I
NP_001020732.1
NP_001020733.1
NP_001334319.1
NP_001346147.1
NP_001346148.1
NP_062674.2
XP_006535211.1
XP_017176503.1
XP_017176504.1
XP_036021224.1
XP_036021225.1
XP_036021226.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025561.3NP_001020732.1  tRNA pseudouridine synthase A isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC161348
    Consensus CDS
    CCDS19530.1
    UniProtKB/TrEMBL
    H7BX59
    Related
    ENSMUSP00000083844.6, ENSMUST00000086643.12
    Conserved Domains (2) summary
    cd02568
    Location:84354
    PseudoU_synth_PUS1_PUS2; Pseudouridine synthase, PUS1/ PUS2 like
    COG0101
    Location:80377
    TruA; tRNA U38,U39,U40 pseudouridine synthase TruA [Translation, ribosomal structure and biogenesis]
  2. NM_001025562.2NP_001020733.1  tRNA pseudouridine synthase A isoform 3

    See identical proteins and their annotated locations for NP_001020733.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR and 5' coding region and lacks an in-frame segment in the coding region, as compared to variant 1. These differences cause translation initiation at a downstream AUG and an encoded protein (isoform 3) that is shorter than isoform 1. Variants 3 and 6 both encode the same isoform (3).
    Source sequence(s)
    AF116237, BY174054, CF618003
    Consensus CDS
    CCDS39212.1
    UniProtKB/Swiss-Prot
    Q9WU56
    Related
    ENSMUSP00000130814.2, ENSMUST00000170468.8
    Conserved Domains (1) summary
    cd02568
    Location:54306
    PseudoU_synth_PUS1_PUS2; Pseudouridine synthase, PUS1/ PUS2 like
  3. NM_001347390.1NP_001334319.1  tRNA pseudouridine synthase A isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR and 5' coding region and lacks two in-frame segments in the coding region, as compared to variant 1. These differences cause translation initiation at a downstream AUG and an encoded protein (isoform 4) that is shorter than isoform 1.
    Source sequence(s)
    AC161348
    Consensus CDS
    CCDS84929.1
    UniProtKB/Swiss-Prot
    Q9WU56
    Related
    ENSMUSP00000108045.2, ENSMUST00000112426.8
  4. NM_001359218.1NP_001346147.1  tRNA pseudouridine synthase A isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (5) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC161348
    Conserved Domains (1) summary
    cd02568
    Location:54324
    PseudoU_synth_PUS1_PUS2; Pseudouridine synthase, PUS1/ PUS2 like
  5. NM_001359219.1NP_001346148.1  tRNA pseudouridine synthase A isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) is shorter at the N-terminus and lacks an alternate internal segment compared to variant 1. Variants 3 and 6 both encode the same isoform (3).
    Source sequence(s)
    AC161348, AK161521
    Consensus CDS
    CCDS39212.1
    Related
    ENSMUSP00000031481.7, ENSMUST00000031481.13
    Conserved Domains (1) summary
    cd02568
    Location:54306
    PseudoU_synth_PUS1_PUS2; Pseudouridine synthase, PUS1/ PUS2 like
  6. NM_019700.4NP_062674.2  tRNA pseudouridine synthase A isoform 2

    See identical proteins and their annotated locations for NP_062674.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, as compared to variant 1. The encoded isoform 2 thus lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    BU515425, BY331510, CB059120, CF618003
    Consensus CDS
    CCDS19531.1
    UniProtKB/Swiss-Prot
    Q9WU56
    Related
    ENSMUSP00000031483.9, ENSMUST00000031483.15
    Conserved Domains (2) summary
    cd02568
    Location:84336
    PseudoU_synth_PUS1_PUS2; Pseudouridine synthase, PUS1/ PUS2 like
    COG0101
    Location:80359
    TruA; tRNA U38,U39,U40 pseudouridine synthase TruA [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    110921533..110928523 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165333.1XP_036021226.1  tRNA pseudouridine synthase A isoform X1

    Conserved Domains (1) summary
    cd02568
    Location:54324
    PseudoU_synth_PUS1_PUS2; Pseudouridine synthase, PUS1/ PUS2 like
  2. XM_017321015.3XP_017176504.1  tRNA pseudouridine synthase A isoform X2

    UniProtKB/Swiss-Prot
    Q9WU56
    Conserved Domains (1) summary
    cd02568
    Location:54306
    PseudoU_synth_PUS1_PUS2; Pseudouridine synthase, PUS1/ PUS2 like
  3. XM_036165332.1XP_036021225.1  tRNA pseudouridine synthase A isoform X1

    Conserved Domains (1) summary
    cd02568
    Location:54324
    PseudoU_synth_PUS1_PUS2; Pseudouridine synthase, PUS1/ PUS2 like
  4. XM_017321014.2XP_017176503.1  tRNA pseudouridine synthase A isoform X2

    UniProtKB/Swiss-Prot
    Q9WU56
    Conserved Domains (1) summary
    cd02568
    Location:54306
    PseudoU_synth_PUS1_PUS2; Pseudouridine synthase, PUS1/ PUS2 like
  5. XM_036165331.1XP_036021224.1  tRNA pseudouridine synthase A isoform X1

    Conserved Domains (1) summary
    cd02568
    Location:54324
    PseudoU_synth_PUS1_PUS2; Pseudouridine synthase, PUS1/ PUS2 like
  6. XM_006535148.3XP_006535211.1  tRNA pseudouridine synthase A isoform X3

    Conserved Domains (1) summary
    cd02568
    Location:84290
    PseudoU_synth_PUS1_PUS2; Pseudouridine synthase, PUS1/ PUS2 like
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