Tmeff2 transmembrane protein with EGF-like and two follistatin-like domains 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmeff2provided by MGI
Official Full Name: transmembrane protein with EGF-like and two follistatin-like domains 2provided by MGI
Primary source: MGI:MGI:1861735
See related: Ensembl:ENSMUSG00000026109 AllianceGenome:MGI:1861735
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TR-2; 4832418D20Rik; 7630402F16Rik
Summary: Predicted to be involved in several processes, including animal organ morphogenesis; cell migration; and substrate adhesion-dependent cell spreading. Predicted to act upstream of or within negative regulation of cell migration; negative regulation of cellular component organization; and wound healing, spreading of cells. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in basement membrane and plasma membrane. Is expressed in several structures, including embryo mesenchyme; intestine; and nervous system. Human ortholog(s) of this gene implicated in prostate cancer and urinary bladder cancer. Orthologous to human TMEFF2 (transmembrane protein with EGF like and two follistatin like domains 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cerebellum adult (RPKM 14.7), CNS E18 (RPKM 13.1) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C1.1; 1 25.95 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (50951946..51226429)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (50900683..51187270)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Together, these data suggested that Tmeff2 is specifically upregulated in oligodendrocytes, but dispensable for oligodendrocyte differentiation and maturation.
Title: Tmeff2 is expressed in differentiating oligodendrocytes but dispensable for their differentiation in vivo.
Results suggest that TMEFF2 is a brain-enriched endogenous modulator of Abeta neurotoxicity and an enhancer of alpha-secretase processing of AbetaPP
Title: Tomoregulin (TMEFF2) Binds Alzheimer's Disease Amyloid-β (Aβ) Oligomer and AβPP and Protects Neurons from Aβ-Induced Toxicity.
Loss of TMEFF2 is associated with cell migration and invasion leading to prostate cancer.
Title: The TMEFF2 tumor suppressor modulates integrin expression, RhoA activation and migration of prostate cancer cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of cell migration	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within negative regulation of integrin biosynthetic process	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within negative regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within wound healing, spreading of cells	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tomoregulin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019790.4 → NP_062764.1 tomoregulin-2 precursor

See identical proteins and their annotated locations for NP_062764.1

Status: VALIDATED

Source sequence(s)

AK029307

Consensus CDS

CCDS14939.1

UniProtKB/Swiss-Prot

Q3UY20, Q8CDH1, Q9JJE3, Q9QYM9

Related

ENSMUSP00000080533.4, ENSMUST00000081851.4

Conserved Domains (3) summary

PHA02887
Location:236 → 301

PHA02887; EGF-like protein; Provisional

smart00280
Location:181 → 227

KAZAL; Kazal type serine protease inhibitors

cd00104
Location:95 → 135

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

50951946..51226429

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030255650.2 → XP_030111510.1 tomoregulin-2 isoform X1

UniProtKB/Swiss-Prot

Q3UY20, Q8CDH1, Q9JJE3, Q9QYM9

Conserved Domains (3) summary

PHA02887
Location:236 → 301

PHA02887; EGF-like protein; Provisional

smart00280
Location:181 → 227

KAZAL; Kazal type serine protease inhibitors

cd00104
Location:95 → 135

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
XM_036152485.1 → XP_036008378.1 tomoregulin-2 isoform X2

Conserved Domains (3) summary

PHA02887
Location:245 → 281

PHA02887; EGF-like protein; Provisional

smart00280
Location:181 → 227

KAZAL; Kazal type serine protease inhibitors

cd00104
Location:95 → 135

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...