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Copz1 coatomer protein complex, subunit zeta 1 [ Mus musculus (house mouse) ]

Gene ID: 56447, updated on 11-Apr-2024

Summary

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Official Symbol
Copz1provided by MGI
Official Full Name
coatomer protein complex, subunit zeta 1provided by MGI
Primary source
MGI:MGI:1929063
See related
Ensembl:ENSMUSG00000060992 AllianceGenome:MGI:1929063
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D4Ertd360e; 5930435A22Rik
Summary
Acts upstream of or within toxin transport. Predicted to be located in Golgi apparatus; cytoplasmic vesicle; and membrane. Predicted to be part of COPI vesicle coat. Orthologous to human COPZ1 (COPI coat complex subunit zeta 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 79.6), liver E14.5 (RPKM 69.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Copz1 in Genome Data Viewer
Location:
15 F3; 15 58.74 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (103181261..103208295)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (103272888..103299865)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A1 Neighboring gene STARR-seq mESC enhancer starr_39872 Neighboring gene nuclear factor, erythroid derived 2 Neighboring gene STARR-positive B cell enhancer ABC_E81 Neighboring gene microRNA 148b Neighboring gene predicted gene, 41406 Neighboring gene STARR-positive B cell enhancer ABC_E3160 Neighboring gene STARR-positive B cell enhancer ABC_E1487 Neighboring gene G protein-coupled receptor 84 Neighboring gene zinc finger protein 385A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Differential localization of coatomer complex isoforms within the Golgi apparatus. Moelleken J, et al. Proc Natl Acad Sci U S A, 2007 Mar 13. PMID 17360540
  2. CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells. Slater LH, et al. Proc Natl Acad Sci U S A, 2013 Jun 11. PMID 23716698, Free PMC Article
  3. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  5. The central role of EED in the orchestration of polycomb group complexes. Cao Q, et al. Nat Commun, 2014. PMID 24457600, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. analysis of differential localization of coatomer complex isoforms within the Golgi apparatus
    Title: Differential localization of coatomer complex isoforms within the Golgi apparatus.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC118060

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in intra-Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intra-Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of COPI vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of COPI vesicle coat ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of membrane coat IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
coatomer subunit zeta-1
Names
nonclathrin coat protein zeta1-COP
zeta-1 COP
zeta-1-coat protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357748.1 → NP_001344677.1  coatomer subunit zeta-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC164069
    UniProtKB/TrEMBL
    Q8R3M1
    Related
    ENSMUSP00000155674.2, ENSMUST00000230893.2
    Conserved Domains (1) summary
    cd14829
    Location:14 → 145
    Zeta-COP; zeta subunit of the F-COPI complex

  2. NM_019817.2 → NP_062791.1  coatomer subunit zeta-1 isoform 2

    See identical proteins and their annotated locations for NP_062791.1

    Status: VALIDATED

    Source sequence(s)
    AC164069
    Consensus CDS
    CCDS27901.1
    UniProtKB/Swiss-Prot
    P61924
    UniProtKB/TrEMBL
    Q542M2, Q8R3M1
    Related
    ENSMUSP00000097738.4, ENSMUST00000100162.5
    Conserved Domains (1) summary
    cd14829
    Location:14 → 145
    Zeta-COP; zeta subunit of the F-COPI complex

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    103181261..103208295
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004938859.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P61924.1 GenPept UniProtKB/Swiss-Prot:P61924

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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