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dcaf6 ddb1 and cul4 associated factor 6 [ Danio rerio (zebrafish) ]

Gene ID: 564498, updated on 27-Mar-2024

Summary

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Official Symbol
dcaf6provided by ZNC
Official Full Name
ddb1 and cul4 associated factor 6provided by ZNC
Primary source
ZFIN:ZDB-GENE-090206-2
See related
Ensembl:ENSDARG00000078311 AllianceGenome:ZFIN:ZDB-GENE-090206-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
iqwd1; si:rp71-20i5.1
Summary
Predicted to enable nuclear receptor coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human DCAF6 (DDB1 and CUL4 associated factor 6). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 9
Exon count:
21
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (34165360..34219375, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (34356175..34410217, complement)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene coagulation factor V Neighboring gene G protein-coupled receptor 161a Neighboring gene mitochondrial pyruvate carrier 2b Neighboring gene neurexophilin and PC-esterase domain family, member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Identification and spatiotemporal expression of gpr161 genes in zebrafish. Wang M, et al. Gene, 2020 Mar 10. PMID 31884103
  2. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables nuclear receptor coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Cul4-RING E3 ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
DDB1- and CUL4-associated factor 6
Names
IQ motif and WD repeats 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145090.1 → NP_001138562.1  DDB1- and CUL4-associated factor 6

    Status: PROVISIONAL

    Source sequence(s)
    AL590146, BX546477
    UniProtKB/TrEMBL
    A0A8M1NPV9, B0QZE8
    Related
    ENSDARP00000102072.2, ENSDART00000113194.4
    Conserved Domains (4) summary
    PHA03255
    Location:488 → 659
    PHA03255; BDLF3; Provisional
    COG2319
    Location:39 → 284
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:52 → 89
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:40 → 283
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    34165360..34219375 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005167843.4 → XP_005167900.1  DDB1- and CUL4-associated factor 6 isoform X4

    UniProtKB/TrEMBL
    A0A8M2BFB1
    Conserved Domains (3) summary
    COG2319
    Location:39 → 284
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:52 → 89
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:40 → 283
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_005167841.4 → XP_005167898.1  DDB1- and CUL4-associated factor 6 isoform X2

    UniProtKB/TrEMBL
    A0A8M2BF97
    Conserved Domains (3) summary
    COG2319
    Location:39 → 284
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:52 → 89
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:40 → 283
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. XM_005167840.4 → XP_005167897.1  DDB1- and CUL4-associated factor 6 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BFX4
    Conserved Domains (3) summary
    COG2319
    Location:39 → 284
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:52 → 89
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:40 → 283
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. XM_009304842.3 → XP_009303117.1  DDB1- and CUL4-associated factor 6 isoform X6

    UniProtKB/TrEMBL
    A0A8M3AW71
    Conserved Domains (3) summary
    COG2319
    Location:39 → 284
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:52 → 89
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:40 → 283
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  5. XM_005167844.4 → XP_005167901.1  DDB1- and CUL4-associated factor 6 isoform X5

    UniProtKB/TrEMBL
    A0A8M2BFB4
    Conserved Domains (3) summary
    COG2319
    Location:39 → 284
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:52 → 89
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:40 → 283
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  6. XM_005167842.4 → XP_005167899.1  DDB1- and CUL4-associated factor 6 isoform X3

    UniProtKB/TrEMBL
    A0A8M2BFA9
    Conserved Domains (3) summary
    COG2319
    Location:39 → 284
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:52 → 89
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:40 → 283
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version

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