scara5 scavenger receptor class A, member 5 (putative) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: scara5provided by ZNC
Official Full Name: scavenger receptor class A, member 5 (putative)provided by ZNC
Primary source: ZFIN:ZDB-GENE-041210-258
See related: Ensembl:ENSDARG00000010425 AllianceGenome:ZFIN:ZDB-GENE-041210-258
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:ch211-200p13.4
Summary: Predicted to enable ferritin receptor activity. Predicted to be involved in several processes, including cellular iron ion homeostasis; iron ion transmembrane transport; and protein homotrimerization. Predicted to act upstream of or within ion transport and iron ion homeostasis. Predicted to be integral component of plasma membrane. Predicted to be active in external side of plasma membrane. Orthologous to human SCARA5 (scavenger receptor class A member 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (1353136..1383877, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (1334316..1362992, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SCARA5 is an HMGB1 recognition receptor that is negatively involved in HMGB1-mediated inflammation in pufferfish (Tetraodon nigroviridis) and zebrafish (Danio rerio) models.
Title: Scavenger Receptor SCARA5 Acts as an HMGB1 Recognition Molecule Negatively Involved in HMGB1-Mediated Inflammation in Fish Models.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ferritin receptor activity	IEA Inferred from Electronic Annotation more info
enables ferritin receptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in endocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular iron ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within iron ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in iron ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within iron ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in protein homotrimerization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: scavenger receptor class A member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001030190.1 → NP_001025361.1 scavenger receptor class A member 5

See identical proteins and their annotated locations for NP_001025361.1

Status: PROVISIONAL

Source sequence(s)

CR536610

UniProtKB/Swiss-Prot

Q5RFW0

Related

ENSDARP00000150337.1, ENSDART00000181830.1

Conserved Domains (3) summary

pfam01391
Location:308 → 371

Collagen; Collagen triple helix repeat (20 copies)

smart00202
Location:398 → 498

SR; Scavenger receptor Cys-rich

pfam00530
Location:403 → 498

SRCR; Scavenger receptor cysteine-rich domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007131.7 Reference GRCz11 Primary Assembly

Range

1353136..1383877 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005160318.4 → XP_005160375.1 scavenger receptor class A member 5 isoform X1

See identical proteins and their annotated locations for XP_005160375.1

UniProtKB/Swiss-Prot

Q5RFW0

Related

ENSDARP00000126688.1, ENSDART00000152373.2

Conserved Domains (3) summary

pfam01391
Location:308 → 371

Collagen; Collagen triple helix repeat (20 copies)

smart00202
Location:398 → 498

SR; Scavenger receptor Cys-rich

pfam00530
Location:403 → 498

SRCR; Scavenger receptor cysteine-rich domain