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Get3 guided entry of tail-anchored proteins factor 3, ATPase [ Mus musculus (house mouse) ]

Gene ID: 56495, updated on 21-Apr-2024

Summary

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Official Symbol
Get3provided by MGI
Official Full Name
guided entry of tail-anchored proteins factor 3, ATPaseprovided by MGI
Primary source
MGI:MGI:1928379
See related
Ensembl:ENSMUSG00000052456 AllianceGenome:MGI:1928379
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ArsA; Asna1; 1810048H22Rik
Summary
Predicted to enable ATP hydrolysis activity. Predicted to be involved in posttranslational protein targeting to endoplasmic reticulum membrane and tail-anchored membrane protein insertion into ER membrane. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of GET complex. Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and vibrissa. Orthologous to human GET3 (guided entry of tail-anchored proteins factor 3, ATPase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 83.4), testis adult (RPKM 69.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 C3; 8 41.48 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (85744558..85751916, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (85017929..85025287, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3789 Neighboring gene hook microtubule tethering protein 2 Neighboring gene bestrophin 2 Neighboring gene STARR-seq mESC enhancer starr_22148 Neighboring gene STARR-positive B cell enhancer ABC_E884 Neighboring gene STARR-positive B cell enhancer ABC_E8254 Neighboring gene telomerase RNA component interacting RNase Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:87560506-87560689 Neighboring gene transportin 2 (importin 3, karyopherin beta 2b) Neighboring gene predicted gene, 25506

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Targeted disruption of the mouse Asna1 gene results in embryonic lethality. Mukhopadhyay R, et al. FEBS Lett, 2006 Jul 10. PMID 16797549
  2. Genomic organization and chromosomal localization of the Asna1 gene, a mouse homologue of a bacterial arsenic-translocating ATPase gene. Bhattacharjee H, et al. Gene, 2001 Jul 11. PMID 11470536
  3. Asna1/TRC40 Controls β-Cell Function and Endoplasmic Reticulum Homeostasis by Ensuring Retrograde Transport. Norlin S, et al. Diabetes, 2016 Jan. PMID 26438609
  4. Distinct targeting pathways for the membrane insertion of tail-anchored (TA) proteins. Favaloro V, et al. J Cell Sci, 2008 Jun 1. PMID 18477612, Free PMC Article
  5. Tryptophan-rich basic protein (WRB) mediates insertion of the tail-anchored protein otoferlin and is required for hair cell exocytosis and hearing. Vogl C, et al. EMBO J, 2016 Dec 1. PMID 27458190, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These findings support a role for the Asna1 ATPase activity in ensuring the survival of pancreatic multipotent progenitor cells , possibly by counteracting p53-mediated apoptosis.
    Title: The ATPase activity of Asna1/TRC40 is required for pancreatic progenitor cell survival.
  2. Asna1 ensures retrograde transport and ER and insulin homeostasis in beta-cells. Asna1 KO mice develop hypoinsulinemia, impaired insulin secretion, and glucose intolerance that rapidly progresses to overt diabetes.
    Title: Asna1/TRC40 Controls β-Cell Function and Endoplasmic Reticulum Homeostasis by Ensuring Retrograde Transport.
  3. These findings indicate that Asna1 plays a crucial role during early embryonic development.
    Title: Targeted disruption of the mouse Asna1 gene results in embryonic lethality.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables membrane insertase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within post-translational protein targeting to endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in tail-anchored membrane protein insertion into ER membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tail-anchored membrane protein insertion into ER membrane ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of GET complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of GET complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ATPase GET3
Names
ATPase Asna1
arsenical pump-driving ATPase
arsenite-stimulated ATPase
arsenite-translocating ATPase
NP_001344131.1
NP_001344132.1
NP_062626.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357202.1 → NP_001344131.1  ATPase GET3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC163703
    UniProtKB/TrEMBL
    Q8VEI6
    Conserved Domains (1) summary
    cl38936
    Location:1 → 217
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_001357203.1 → NP_001344132.1  ATPase GET3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC163703
    UniProtKB/TrEMBL
    Q8VEI6
    Conserved Domains (1) summary
    cl38936
    Location:1 → 217
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. NM_019652.2 → NP_062626.1  ATPase GET3 isoform 1

    See identical proteins and their annotated locations for NP_062626.1

    Status: VALIDATED

    Source sequence(s)
    BC083335, BY230823, BY631769
    Consensus CDS
    CCDS40417.1
    UniProtKB/Swiss-Prot
    O54984, Q3TAQ4
    Related
    ENSMUSP00000065337.9, ENSMUST00000064314.10
    Conserved Domains (1) summary
    pfam02374
    Location:37 → 340
    ArsA_ATPase; Anion-transporting ATPase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    85744558..85751916 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O54984.2 GenPept UniProtKB/Swiss-Prot:O54984

Gene LinkOut

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