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dyrk4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 [ Danio rerio (zebrafish) ]

Gene ID: 564976, updated on 27-Mar-2024

Summary

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Official Symbol
dyrk4provided by ZNC
Official Full Name
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4provided by ZNC
Primary source
ZFIN:ZDB-GENE-091015-3
See related
Ensembl:ENSDARG00000070734 AllianceGenome:ZFIN:ZDB-GENE-091015-3
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in peptidyl-serine phosphorylation and peptidyl-threonine phosphorylation. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm; cytoskeleton; and nucleus. Orthologous to human DYRK4 (dual specificity tyrosine phosphorylation regulated kinase 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 25
Exon count:
16
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (16785913..16832867, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (16689513..16728946, complement)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene probable polypeptide N-acetylgalactosaminyltransferase 8 Neighboring gene NADH:ubiquinone oxidoreductase subunit A9a Neighboring gene zgc:154077 Neighboring gene zgc:77158 Neighboring gene uncharacterized LOC103909838

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dual specificity tyrosine-phosphorylation-regulated kinase 4
XP_005174422.1
XP_009296230.1
XP_009296231.1
XP_021326340.1
XP_693389.3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    16785913..16832867 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021470665.1 → XP_021326340.1  dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform X3

    UniProtKB/TrEMBL
    A0A8M9PYX5
    Related
    ENSDARP00000139074.1, ENSDART00000171336.2
    Conserved Domains (1) summary
    cd14225
    Location:161 → 501
    PKc_DYRK4; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 4

  2. XM_009297956.3 → XP_009296231.1  dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform X4

    UniProtKB/TrEMBL
    A0A2R8Q5R9, A0A8M3B761
    Related
    ENSDARP00000148276.1, ENSDART00000191299.1
    Conserved Domains (2) summary
    smart00220
    Location:194 → 490
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14225
    Location:150 → 490
    PKc_DYRK4; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 4

  3. XM_009297955.3 → XP_009296230.1  dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform X1

    UniProtKB/TrEMBL
    A0A2R8Q5G9, A0A8M3AP26
    Related
    ENSDARP00000146224.1, ENSDART00000188504.1
    Conserved Domains (2) summary
    smart00220
    Location:222 → 518
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14225
    Location:178 → 518
    PKc_DYRK4; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 4

  4. XM_005174365.4 → XP_005174422.1  dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform X5

    UniProtKB/TrEMBL
    A0A2R8RWZ6, A0A8M2BLK6
    Related
    ENSDARP00000154964.1, ENSDART00000185215.1
    Conserved Domains (2) summary
    smart00220
    Location:184 → 480
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14225
    Location:140 → 480
    PKc_DYRK4; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 4

  5. XM_688297.8 → XP_693389.3  dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform X2

    UniProtKB/TrEMBL
    A0A8N7TF79, E7F1S5
    Related
    ENSDARP00000094915.3, ENSDART00000104140.6
    Conserved Domains (2) summary
    smart00220
    Location:212 → 508
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14225
    Location:168 → 508
    PKc_DYRK4; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 4
Nucleotide Protein
Heading Accession and Version

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