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PSG1 pregnancy specific beta-1-glycoprotein 1 [ Homo sapiens (human) ]

Gene ID: 5669, updated on 3-Apr-2024

Summary

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Official Symbol
PSG1provided by HGNC
Official Full Name
pregnancy specific beta-1-glycoprotein 1provided by HGNC
Primary source
HGNC:HGNC:9514
See related
Ensembl:ENSG00000231924 MIM:176390; AllianceGenome:HGNC:9514
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SP1; B1G1; PBG1; CD66f; PSBG1; PSG95; PSGGA; DHFRP2; PSBG-1; PSGIIA; FL-NCA-1/2; PS-beta-C/D; PS-beta-G-1
Summary
The human placenta is a multihormonal endocrine organ that produces hormones, enzymes, and other molecules that support fetal survival and development. Pregnancy-specific beta-1-glycoprotein (PSBG, PSG) is a major product of the syncytiotrophoblast, reaching concentrations of 100 to 290 mg/l at term in the serum of pregnant women (Horne et al., 1976 [PubMed 971765]). PSG is a member of the immunoglobulin (Ig) superfamily (Watanabe and Chou, 1988 [PubMed 3257488]; Streydio et al., 1988 [PubMed 3260773]).[supplied by OMIM, Oct 2009]
Expression
Restricted expression toward placenta (RPKM 224.3) See more
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Genomic context

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Location:
19q13.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (42866464..42879713, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (45685415..45698666, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (43370616..43383865, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene PSG8 antisense RNA 1 Neighboring gene pregnancy specific beta-1-glycoprotein 10, pseudogene Neighboring gene pregnancy specific beta-1-glycoprotein 6 Neighboring gene pregnancy specific beta-1-glycoprotein 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. High Expression of Pregnancy Specific Beta-1-glycoprotein 1 Is Associated With Poor Gastric Cancer Prognosis. Kang HG, et al. In Vivo, 2022 Nov-Dec. PMID 36309385, Free PMC Article
  2. Effect of Pregnancy Specific β1-Glycoprotein on the Replicative Potential of Naïve T Cells and Immune Memory T Cells. Timganova VP, et al. Bull Exp Biol Med, 2021 Dec. PMID 34855088
  3. Glycan characterization of pregnancy-specific glycoprotein 1 and its identification as a novel Galectin-1 ligand. Mendoza M, et al. Glycobiology, 2020 Oct 21. PMID 32280962, Free PMC Article
  4. Targeting PSG1 to enhance chemotherapeutic efficacy: new application for anti-coagulant the dicumarol. He DX, et al. Clin Sci (Lond), 2016 Dec 1. PMID 27653744
  5. Pregnancy-specific glycoprotein expression in normal gastrointestinal tract and in tumors detected with novel monoclonal antibodies. Houston A, et al. MAbs, 2016. PMID 26926266, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Low pregnancy-specific beta-1-glycoprotein is associated with nondipper hypertension and increased risk of preeclampsia in pregnant women with newly diagnosed chronic hypertension.
    Title: Low pregnancy-specific beta-1-glycoprotein is associated with nondipper hypertension and increased risk of preeclampsia in pregnant women with newly diagnosed chronic hypertension.
  2. High Expression of Pregnancy Specific Beta-1-glycoprotein 1 Is Associated With Poor Gastric Cancer Prognosis.
    Title: High Expression of Pregnancy Specific Beta-1-glycoprotein 1 Is Associated With Poor Gastric Cancer Prognosis.
  3. Effect of Pregnancy Specific beta1-Glycoprotein on the Replicative Potential of Naive T Cells and Immune Memory T Cells.
    Title: Effect of Pregnancy Specific β1-Glycoprotein on the Replicative Potential of Naïve T Cells and Immune Memory T Cells.
  4. Glycan characterization of pregnancy-specific glycoprotein 1 and its identification as a novel Galectin-1 ligand.
    Title: Glycan characterization of pregnancy-specific glycoprotein 1 and its identification as a novel Galectin-1 ligand.
  5. biomarkers suitable for the assessment of chronological ageing were identified, and extrapolated to the context of photo-damaged skin. In particular, KANK4, ACAN, Col XI alpha1, and PSG1, were expressed at an increased level in both chronologically-aged and photo-damaged skin.
    Title: Genome-wide profiling of adult human papillary and reticular fibroblasts identifies ACAN, Col XI α1, and PSG1 as general biomarkers of dermis ageing, and KANK4 as an exemplary effector of papillary fibroblast ageing, related to contractility.
  6. Inhibiting PSG1 can effectively reduce chemoresistance via a transforming growth factor-beta (TGF-beta)-related pathway in ER-negative breast cancer cells.
    Title: Targeting PSG1 to enhance chemotherapeutic efficacy: new application for anti-coagulant the dicumarol.
  7. PSG stimulated IDO activity under the conditions of induction of the monocytes by interferon-gamma.
    Title: Effect of pregnancy-specific β1-glycoprotein on indoleamine-2,3-dioxygenase activity in human monocytes.
  8. Under conditions of directed induction of phenotypic changes in CD4(+) lymphocytes to regulatory T cells (Treg), pregnancy-specific at high concentrations (10 and 100 mug/mL) increased FOXP3 expression. The evaluation of the spontaneous expression level of FOXP3 mRNA showed that pregnancy-specific beta1-glycoprotein (1 and 100 mug/mL) stimulated the expression of this factor in mononuclear cells and isolated CD4(+) lym...
    Title: The effect of pregnancy-specific β1-glycoprotein 1 on the transcription factor FOXP3 expression by immunocompetent cells.
  9. results identify a non-placental site of PSG expression in the gut and associated tumors, with implications for determining whether PSGs have a role in tumor progression, and utility as tumor biomarkers.
    Title: Pregnancy-specific glycoprotein expression in normal gastrointestinal tract and in tumors detected with novel monoclonal antibodies.
  10. the presence of GAGs on the surface of endothelial cells was required for the ability of PSG1 to induce tube formation
    Title: Pregnancy-specific glycoprotein 1 induces endothelial tubulogenesis through interaction with cell surface proteoglycans.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ90598, FLJ90654

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in female pregnancy TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
pregnancy-specific beta-1-glycoprotein 1
Names
CD66 antigen-like family member F
fetal liver non-specific cross-reactive antigen 1/2
pregnancy-specific B-1 glycoprotein
pregnancy-specific beta-1 glycoprotein C/D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001184825.2 → NP_001171754.1  pregnancy-specific beta-1-glycoprotein 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001171754.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 3' terminal exon, compared to variant 4. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 4.
    Source sequence(s)
    AC005238
    Consensus CDS
    CCDS54275.1
    UniProtKB/Swiss-Prot
    O75236, P11462, P11463, P11464, Q15231, Q15241, Q15243, Q16660, Q6ICR4, Q9P1W5, Q9UQ79
    UniProtKB/TrEMBL
    Q96QL5
    Related
    ENSP00000413041.2, ENST00000436291.7
    Conserved Domains (3) summary
    pfam13895
    Location:335 → 413
    Ig_2; Immunoglobulin domain
    cd05774
    Location:36 → 138
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    cl11960
    Location:148 → 236
    Ig; Immunoglobulin domain

  2. NM_001184826.2 → NP_001171755.1  pregnancy-specific beta-1-glycoprotein 1 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001171755.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 3' terminal exon, compared to variant 4. It encodes isoform 3, which has a shorter and distinct C-terminus, compared to isoform 4.
    Source sequence(s)
    AC005238
    Consensus CDS
    CCDS59392.1
    UniProtKB/TrEMBL
    Q96QL5
    Related
    ENSP00000472610.1, ENST00000595356.5
    Conserved Domains (4) summary
    cd05774
    Location:36 → 138
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:339 → 413
    IG_like; Immunoglobulin like
    pfam13895
    Location:335 → 413
    Ig_2; Immunoglobulin domain
    cl11960
    Location:148 → 236
    Ig; Immunoglobulin domain

  3. NM_001297773.2 → NP_001284702.1  pregnancy-specific beta-1-glycoprotein 1 isoform 4 precursor

    See identical proteins and their annotated locations for NP_001284702.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (4).
    Source sequence(s)
    AC005238, M20879
    Consensus CDS
    CCDS74380.1
    UniProtKB/TrEMBL
    Q96QL5
    Related
    ENSP00000308970.6, ENST00000312439.10
    Conserved Domains (4) summary
    cd05774
    Location:36 → 138
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:339 → 413
    IG_like; Immunoglobulin like
    pfam13895
    Location:335 → 413
    Ig_2; Immunoglobulin domain
    cl11960
    Location:148 → 236
    Ig; Immunoglobulin domain

  4. NM_001330524.2 → NP_001317453.1  pregnancy-specific beta-1-glycoprotein 1 isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AC005238, DA829309
    Consensus CDS
    CCDS82360.1
    UniProtKB/TrEMBL
    G5E9F7, Q8NC17
    Related
    ENSP00000385386.3, ENST00000403380.7
    Conserved Domains (4) summary
    cd05774
    Location:36 → 138
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:246 → 320
    IG_like; Immunoglobulin like
    pfam13895
    Location:242 → 320
    Ig_2; Immunoglobulin domain
    cl11960
    Location:148 → 236
    Ig; Immunoglobulin domain

  5. NM_006905.3 → NP_008836.2  pregnancy-specific beta-1-glycoprotein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_008836.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses alternate splice sites in the 3' terminal exon, compared to variant 4. It encodes isoform 1, which has a shorter and distinct C-terminus, compared to isoform 4.
    Source sequence(s)
    AC005238, BC022338
    Consensus CDS
    CCDS12612.1
    UniProtKB/TrEMBL
    Q96QL5
    Related
    ENSP00000244296.2, ENST00000244296.6
    Conserved Domains (4) summary
    cd05774
    Location:36 → 138
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:339 → 413
    IG_like; Immunoglobulin like
    pfam13895
    Location:335 → 413
    Ig_2; Immunoglobulin domain
    cl11960
    Location:148 → 236
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    42866464..42879713 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259065.4 → XP_005259122.1  pregnancy-specific beta-1-glycoprotein 1 isoform X1

    UniProtKB/TrEMBL
    Q8NC17
    Conserved Domains (4) summary
    cd05774
    Location:36 → 138
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:246 → 320
    IG_like; Immunoglobulin like
    pfam13895
    Location:242 → 320
    Ig_2; Immunoglobulin domain
    cl11960
    Location:148 → 236
    Ig; Immunoglobulin domain

  2. XM_011527125.2 → XP_011525427.1  pregnancy-specific beta-1-glycoprotein 1 isoform X2

    See identical proteins and their annotated locations for XP_011525427.1

    UniProtKB/TrEMBL
    O75238, Q9UPK8
    Conserved Domains (4) summary
    cd05774
    Location:36 → 138
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:246 → 320
    IG_like; Immunoglobulin like
    pfam13895
    Location:242 → 320
    Ig_2; Immunoglobulin domain
    cl11960
    Location:148 → 236
    Ig; Immunoglobulin domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    45685415..45698666 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321485.1 → XP_054177460.1  pregnancy-specific beta-1-glycoprotein 1 isoform X1

  2. XM_054321486.1 → XP_054177461.1  pregnancy-specific beta-1-glycoprotein 1 isoform X2

    UniProtKB/TrEMBL
    O75238
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P11464.1 GenPept UniProtKB/Swiss-Prot:P11464

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