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fhl3a four and a half LIM domains 3a [ Danio rerio (zebrafish) ]

Gene ID: 567097, updated on 27-Mar-2024

Summary

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Official Symbol
fhl3aprovided by ZNC
Official Full Name
four and a half LIM domains 3aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-4741
See related
Ensembl:ENSDARG00000034643 AllianceGenome:ZFIN:ZDB-GENE-030131-4741
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fhl3; fd57e01; wu:fd57e01
Summary
Predicted to enable actin binding activity and transcription coregulator activity. Predicted to be involved in actin cytoskeleton organization. Predicted to be active in Z disc; nucleus; and stress fiber. Orthologous to human FHL3 (four and a half LIM domains 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 16
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (33655873..33736832)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (33701800..33782805)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene POU class 3 homeobox 1 Neighboring gene UTP11 small subunit processome component Neighboring gene si:ch211-232m19.4 Neighboring gene R-spondin 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Transcriptomics approach to investigate zebrafish heart regeneration. Sleep E, et al. J Cardiovasc Med (Hagerstown), 2010 May. PMID 20179605
  2. Pou3f transcription factor expression during embryonic development highlights distinct pou3f3 and pou3f4 localization in the Xenopus laevis kidney. Cosse-Etchepare C, et al. Int J Dev Biol, 2018. PMID 29877572
  3. Gene expression profiling of zebrafish embryonic retinal pigment epithelium in vivo. Leung YF, et al. Invest Ophthalmol Vis Sci, 2007 Feb. PMID 17251491, Free PMC Article
  4. Many genes in fish have species-specific asymmetric rates of molecular evolution. Steinke D, et al. BMC Genomics, 2006 Feb 8. PMID 16466575, Free PMC Article
  5. Identification of vascular and hematopoietic genes downstream of etsrp by deep sequencing in zebrafish. Gomez G, et al. PLoS One, 2012. PMID 22438865, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Z disc IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
four and a half LIM domains protein 3
Names
four and a half LIM domains 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    33655873..33736832
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_690386.9 → XP_695478.2  four and a half LIM domains protein 3

    UniProtKB/TrEMBL
    A0A8M9PFP5, E7EZP9
    Related
    ENSDARP00000121030.1, ENSDART00000143757.2
    Conserved Domains (5) summary
    cd09346
    Location:162 → 213
    LIM3_FHL; The third LIM domain of Four and a half LIM domains protein (FHL)
    cd09423
    Location:36 → 94
    LIM1_FHL3; The first LIM domain of Four and a half LIM domains protein 3 (FHL3)
    cd09427
    Location:98 → 155
    LIM2_FHL3; The second LIM domain of Four and a half LIM domains protein 3 (FHL3)
    cd09434
    Location:221 → 276
    LIM4_FHL3; The fourth LIM domain of Four and a half LIM domains protein 3 (FHL3)
    cl02475
    Location:5 → 33
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  2. XM_021466948.1 → XP_021322623.1  four and a half LIM domains protein 3

    UniProtKB/TrEMBL
    A0A8M9PFP5, E7EZP9
    Conserved Domains (5) summary
    cd09346
    Location:162 → 213
    LIM3_FHL; The third LIM domain of Four and a half LIM domains protein (FHL)
    cd09423
    Location:36 → 94
    LIM1_FHL3; The first LIM domain of Four and a half LIM domains protein 3 (FHL3)
    cd09427
    Location:98 → 155
    LIM2_FHL3; The second LIM domain of Four and a half LIM domains protein 3 (FHL3)
    cd09434
    Location:221 → 276
    LIM4_FHL3; The fourth LIM domain of Four and a half LIM domains protein 3 (FHL3)
    cl02475
    Location:5 → 33
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395326.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    415573..496555
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021474356.1 → XP_021330031.1  four and a half LIM domains protein 3

    UniProtKB/TrEMBL
    A0A8M9PFP5, E7EZP9
    Conserved Domains (5) summary
    cd09346
    Location:162 → 213
    LIM3_FHL; The third LIM domain of Four and a half LIM domains protein (FHL)
    cd09423
    Location:36 → 94
    LIM1_FHL3; The first LIM domain of Four and a half LIM domains protein 3 (FHL3)
    cd09427
    Location:98 → 155
    LIM2_FHL3; The second LIM domain of Four and a half LIM domains protein 3 (FHL3)
    cd09434
    Location:221 → 276
    LIM4_FHL3; The fourth LIM domain of Four and a half LIM domains protein 3 (FHL3)
    cl02475
    Location:5 → 33
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  2. XM_021474357.1 → XP_021330032.1  four and a half LIM domains protein 3

    UniProtKB/TrEMBL
    A0A8M9PFP5, E7EZP9
    Conserved Domains (5) summary
    cd09346
    Location:162 → 213
    LIM3_FHL; The third LIM domain of Four and a half LIM domains protein (FHL)
    cd09423
    Location:36 → 94
    LIM1_FHL3; The first LIM domain of Four and a half LIM domains protein 3 (FHL3)
    cd09427
    Location:98 → 155
    LIM2_FHL3; The second LIM domain of Four and a half LIM domains protein 3 (FHL3)
    cd09434
    Location:221 → 276
    LIM4_FHL3; The fourth LIM domain of Four and a half LIM domains protein 3 (FHL3)
    cl02475
    Location:5 → 33
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
Nucleotide Protein Strain
Heading Accession and Version

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