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maml1 mastermind-like transcriptional coactivator 1 [ Danio rerio (zebrafish) ]

Gene ID: 567335, updated on 27-Mar-2024

Summary

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Official Symbol
maml1provided by ZNC
Official Full Name
mastermind-like transcriptional coactivator 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-100820-2
See related
Ensembl:ENSDARG00000076466 AllianceGenome:ZFIN:ZDB-GENE-100820-2
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable transcription coactivator activity. Predicted to act upstream of or within Notch signaling pathway and positive regulation of transcription by RNA polymerase II. Predicted to be located in nuclear speck. Is expressed in telencephalon. Orthologous to human MAML1 (mastermind like transcriptional coactivator 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 14
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (16382507..16424596, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (16076854..16119174, complement)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene intelectin 3 Neighboring gene leukotriene C4 synthase Neighboring gene calnexin Neighboring gene alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Calnexin is required for zebrafish posterior lateral line development. Hung IC, et al. Int J Dev Biol, 2013. PMID 23873374
  2. Notch activity levels control the balance between quiescence and recruitment of adult neural stem cells. Chapouton P, et al. J Neurosci, 2010 Jun 9. PMID 20534844, Free PMC Article
  3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of transcription of Notch receptor target IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mastermind-like protein 1
Names
mastermind-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    16382507..16424596 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005157216.4 → XP_005157273.2  mastermind-like protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0R4IKI2, A0A8M2B411
    Related
    ENSDARP00000134496.2, ENSDART00000161793.2
    Conserved Domains (1) summary
    pfam09596
    Location:8 → 65
    MamL-1; MamL-1 domain

  2. XM_690627.7 → XP_695719.5  mastermind-like protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8N7TF91
    Related
    ENSDARP00000102289.3, ENSDART00000108868.4
    Conserved Domains (1) summary
    pfam09596
    Location:8 → 65
    MamL-1; MamL-1 domain
Nucleotide Protein Strain
Heading Accession and Version

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