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C1qtnf1 C1q and tumor necrosis factor related protein 1 [ Mus musculus (house mouse) ]

Gene ID: 56745, updated on 21-Apr-2024

Summary

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Official Symbol
C1qtnf1provided by MGI
Official Full Name
C1q and tumor necrosis factor related protein 1provided by MGI
Primary source
MGI:MGI:1919254
See related
Ensembl:ENSMUSG00000017446 AllianceGenome:MGI:1919254
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Adip; CTRP1; Zsig37; 1600017K21Rik
Summary
Enables identical protein binding activity. Acts upstream of or within positive regulation of MAPK cascade; positive regulation of protein kinase B signaling; and regulation of glucose metabolic process. Located in extracellular space. Is expressed in axial skeleton; heart; tooth; and vibrissa. Orthologous to human C1QTNF1 (C1q and TNF related 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in mammary gland adult (RPKM 21.5), subcutaneous fat pad adult (RPKM 17.9) and 21 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 E2; 11 83.17 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (118319187..118342608)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (118428457..118451782)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene calcium activated nucleotidase 1 Neighboring gene STARR-positive B cell enhancer ABC_E5311 Neighboring gene predicted gene, 35598 Neighboring gene predicted gene 11747 Neighboring gene STARR-seq mESC enhancer starr_31303 Neighboring gene STARR-positive B cell enhancer ABC_E3042 Neighboring gene ribosomal protein L18 pseudogene Neighboring gene endo-beta-N-acetylglucosaminidase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Aging and chronic high-fat feeding negatively affect kidney size, function, and gene expression in CTRP1-deficient mice. Rodriguez S, et al. Am J Physiol Regul Integr Comp Physiol, 2021 Jan 1. PMID 33085906, Free PMC Article
  2. Late-onset renal hypertrophy and dysfunction in mice lacking CTRP1. Rodriguez S, et al. FASEB J, 2020 Feb. PMID 31908037, Free PMC Article
  3. C1q/TNF-α-Related Protein 1 (CTRP1) Maintains Blood Pressure Under Dehydration Conditions. Han S, et al. Circ Res, 2018 Aug 17. PMID 30030219
  4. C1QTNF1 attenuates angiotensin II-induced cardiac hypertrophy via activation of the AMPKa pathway. Wu L, et al. Free Radic Biol Med, 2018 Jun. PMID 29733904
  5. C1q/TNF-related protein 1 prevents neointimal formation after arterial injury. Kanemura N, et al. Atherosclerosis, 2017 Feb. PMID 28131048

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ER-associated CTRP1 regulates mitochondrial fission via interaction with DRP1.
    Title: ER-associated CTRP1 regulates mitochondrial fission via interaction with DRP1.
  2. CTRP1 Aggravates Cardiac Dysfunction Post Myocardial Infarction by Modulating TLR4 in Macrophages.
    Title: CTRP1 Aggravates Cardiac Dysfunction Post Myocardial Infarction by Modulating TLR4 in Macrophages.
  3. CTRP1 prevents sepsis-induced cardiomyopathy via Sirt1-dependent pathways.
    Title: CTRP1 prevents sepsis-induced cardiomyopathy via Sirt1-dependent pathways.
  4. Aging and chronic high-fat feeding negatively affect kidney size, function, and gene expression in CTRP1-deficient mice.
    Title: Aging and chronic high-fat feeding negatively affect kidney size, function, and gene expression in CTRP1-deficient mice.
  5. Late-onset renal hypertrophy and dysfunction in mice lacking CTRP1.
    Title: Late-onset renal hypertrophy and dysfunction in mice lacking CTRP1.
  6. CTRP1 contributes to the regulation of blood pressure homeostasis by preventing dehydration-induced hypotension.
    Title: C1q/TNF-α-Related Protein 1 (CTRP1) Maintains Blood Pressure Under Dehydration Conditions.
  7. C1QTNF1 deficiency accelerates cardiac hypertrophy and fibrosis through decreasing AMPKa pathway.
    Title: C1QTNF1 attenuates angiotensin II-induced cardiac hypertrophy via activation of the AMPKa pathway.
  8. CTRP1 protected against Dox-induced cardiotoxicity via activation of AKT
    Title: C1qTNF-related protein 1 attenuates doxorubicin-induced cardiac injury via activation of AKT.
  9. CTRP1 functions to prevent the development of pathological vascular remodeling by reducing vascular smooth muscle cell growth and neointima formation through cAMP-dependent pathway.
    Title: C1q/TNF-related protein 1 prevents neointimal formation after arterial injury.
  10. By using en face staining of mouse aorta, the study found CTRP1 expression was significantly increased in vascular endothelial cells under disturbed flow as compared to steady laminar flow.
    Title: C1q/TNF-related protein 1 promotes endothelial barrier dysfunction under disturbed flow.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables collagen binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of platelet activation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of platelet aggregation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of aldosterone secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of glucose metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of collagen trimer IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
complement C1q tumor necrosis factor-related protein 1
Names
adiponectin p
putative secreted protein ZSIG37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204129.1 → NP_001191058.1  complement C1q tumor necrosis factor-related protein 1 precursor

    See identical proteins and their annotated locations for NP_001191058.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK005484, AL591075, BM934297
    Consensus CDS
    CCDS25703.1
    UniProtKB/Swiss-Prot
    Q80VI9, Q9QXP7
    UniProtKB/TrEMBL
    A0A3B0J1J8
    Related
    ENSMUSP00000017590.3, ENSMUST00000017590.9
    Conserved Domains (2) summary
    pfam01391
    Location:98 → 138
    Collagen; Collagen triple helix repeat (20 copies)
    pfam00386
    Location:147 → 275
    C1q; C1q domain

  2. NM_001204130.1 → NP_001191059.1  complement C1q tumor necrosis factor-related protein 1 precursor

    See identical proteins and their annotated locations for NP_001191059.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AL591075
    Consensus CDS
    CCDS25703.1
    UniProtKB/Swiss-Prot
    Q80VI9, Q9QXP7
    UniProtKB/TrEMBL
    A0A3B0J1J8
    Conserved Domains (2) summary
    pfam01391
    Location:98 → 138
    Collagen; Collagen triple helix repeat (20 copies)
    pfam00386
    Location:147 → 275
    C1q; C1q domain

  3. NM_019959.3 → NP_064343.1  complement C1q tumor necrosis factor-related protein 1 precursor

    See identical proteins and their annotated locations for NP_064343.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AL591075, CJ056741
    Consensus CDS
    CCDS25703.1
    UniProtKB/Swiss-Prot
    Q80VI9, Q9QXP7
    UniProtKB/TrEMBL
    A0A3B0J1J8
    Related
    ENSMUSP00000101893.2, ENSMUST00000106286.3
    Conserved Domains (2) summary
    pfam01391
    Location:98 → 138
    Collagen; Collagen triple helix repeat (20 copies)
    pfam00386
    Location:147 → 275
    C1q; C1q domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    118319187..118342608
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156867.1 → XP_036012760.1  complement C1q tumor necrosis factor-related protein 1 isoform X1

    Conserved Domains (2) summary
    pfam00386
    Location:167 → 295
    C1q; C1q domain
    pfam01391
    Location:118 → 158
    Collagen; Collagen triple helix repeat (20 copies)

  2. XM_006533821.4 → XP_006533884.1  complement C1q tumor necrosis factor-related protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006533884.1

    UniProtKB/Swiss-Prot
    Q80VI9, Q9QXP7
    UniProtKB/TrEMBL
    A0A3B0J1J8
    Conserved Domains (2) summary
    pfam01391
    Location:98 → 138
    Collagen; Collagen triple helix repeat (20 copies)
    pfam00386
    Location:147 → 275
    C1q; C1q domain

  3. XM_006533822.5 → XP_006533885.1  complement C1q tumor necrosis factor-related protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006533885.1

    UniProtKB/Swiss-Prot
    Q80VI9, Q9QXP7
    UniProtKB/TrEMBL
    A0A3B0J1J8
    Conserved Domains (2) summary
    pfam01391
    Location:98 → 138
    Collagen; Collagen triple helix repeat (20 copies)
    pfam00386
    Location:147 → 275
    C1q; C1q domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QXP7.1 GenPept UniProtKB/Swiss-Prot:Q9QXP7

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