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prkag2b protein kinase, AMP-activated, gamma 2 non-catalytic subunit b [ Danio rerio (zebrafish) ]

Gene ID: 568316, updated on 27-Mar-2024

Summary

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Official Symbol
prkag2bprovided by ZNC
Official Full Name
protein kinase, AMP-activated, gamma 2 non-catalytic subunit bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070912-442
See related
Ensembl:ENSDARG00000001933 AllianceGenome:ZFIN:ZDB-GENE-070912-442
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
prkag2; si:dkey-217f4.2; si:ch211-230l11.1
Summary
Predicted to enable AMP binding activity; protein kinase binding activity; and protein kinase regulator activity. Predicted to be involved in cellular response to glucose starvation; protein phosphorylation; and regulation of catalytic activity. Predicted to act upstream of or within regulation of protein serine/threonine kinase activity. Predicted to be part of nucleotide-activated protein kinase complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Wolff-Parkinson-White syndrome; glycogen storage disease; hypertrophic cardiomyopathy 6; and lethal congenital glycogen storage disease of heart. Orthologous to human PRKAG2 (protein kinase AMP-activated non-catalytic subunit gamma 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 2
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (13056714..13149212)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (13373930..13466426)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110437990 Neighboring gene lysine (K)-specific methyltransferase 2Cb Neighboring gene BCL2 apoptosis regulator b Neighboring gene 3-ketodihydrosphingosine reductase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Genome-wide association study of kidney function decline in individuals of European descent. Gorski M, et al. Kidney Int, 2015 May. PMID 25493955, Free PMC Article
  2. The Lysosomal Transcription Factor TFEB Represses Myelination Downstream of the Rag-Ragulator Complex. Meireles AM, et al. Dev Cell, 2018 Nov 5. PMID 30399334, Free PMC Article
  3. Efficient identification of CRISPR/Cas9-induced insertions/deletions by direct germline screening in zebrafish. Brocal I, et al. BMC Genomics, 2016 Mar 24. PMID 27009152, Free PMC Article
  4. Genome-wide survey and developmental expression mapping of zebrafish SET domain-containing genes. Sun XJ, et al. PLoS One, 2008 Jan 30. PMID 18231586, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables AMP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of catalytic activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
part_of nucleotide-activated protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
5'-AMP-activated protein kinase subunit gamma-2; 5'-AMP-activated protein kinase subunit gamma-1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    13056714..13149212
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_691638.8 → XP_696730.4  5'-AMP-activated protein kinase subunit gamma-1 isoform X1

    UniProtKB/TrEMBL
    A0A8N7UW19, F1QRT4
    Related
    ENSDARP00000122431.3, ENSDART00000142649.4
    Conserved Domains (3) summary
    COG0517
    Location:403 → 520
    CBS; CBS domain [Signal transduction mechanisms]
    cd04618
    Location:247 → 376
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04641
    Location:403 → 522
    CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

  2. XM_005163300.4 → XP_005163357.1  5'-AMP-activated protein kinase subunit gamma-1 isoform X2

    UniProtKB/TrEMBL
    A0A8M2BAB8
    Related
    ENSDARP00000150928.1, ENSDART00000192832.1
    Conserved Domains (3) summary
    COG0517
    Location:403 → 520
    CBS; CBS domain [Signal transduction mechanisms]
    cd04618
    Location:247 → 376
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04641
    Location:403 → 522
    CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

RNA

  1. XR_223171.4 RNA Sequence

  2. XR_002455801.1 RNA Sequence

  3. XR_001795980.2 RNA Sequence

  4. XR_002455802.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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