dscama Down syndrome cell adhesion molecule a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dscamaprovided by ZNC
Official Full Name: Down syndrome cell adhesion molecule aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050310-7
See related: Ensembl:ENSDARG00000024865 AllianceGenome:ZFIN:ZDB-GENE-050310-7
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: dscam
Summary: Predicted to enable cell-cell adhesion mediator activity. Acts upstream of or within cell migration involved in gastrulation. Is integral component of plasma membrane. Is expressed in nervous system. Orthologous to human DSCAM (DS cell adhesion molecule). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 10

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (38775334..38959079)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (38832001..39015672)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression patterns of dscam and sdk gene paralogs in developing zebrafish retina has been reported.
Title: Expression patterns of dscam and sdk gene paralogs in developing zebrafish retina.
Migrating cells utilize dscam to remodel the developing embryo
Title: The zebrafish down syndrome cell adhesion molecule is involved in cell movement during embryogenesis.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cell-cell adhesion mediator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell migration involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite self-avoidance	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within enteric nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of axon extension involved in axon guidance	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: Down syndrome cell adhesion molecule a

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001030224.2 → NP_001025395.1 Down syndrome cell adhesion molecule a precursor

See identical proteins and their annotated locations for NP_001025395.1

Status: VALIDATED

Source sequence(s)

BX248386, CABZ01051874, CR848005

UniProtKB/TrEMBL

A0A8M1N7R4, Q53CM6

Related

ENSDARP00000108538.1, ENSDART00000125045.4

Conserved Domains (8) summary

cd00096
Location:1311 → 1376

Ig; Immunoglobulin domain

cd05734
Location:707 → 786

Ig7_DSCAM; Seventh immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM)

smart00408
Location:523 → 578

IGc2; Immunoglobulin C-2 Type

smart00410
Location:235 → 310

IG_like; Immunoglobulin like

cd00063
Location:994 → 1091

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:407 → 501

I-set; Immunoglobulin I-set domain

pfam00041
Location:1099 → 1185

fn3; Fibronectin type III domain

cl11960
Location:804 → 897

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007121.7 Reference GRCz11 Primary Assembly

Range

38775334..38959079

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021479191.1 → XP_021334866.1 Down syndrome cell adhesion molecule a isoform X1

UniProtKB/TrEMBL

A0A8M9QGN7

Conserved Domains (9) summary

cd05734
Location:708 → 787

Ig_DSCAM; Immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM)

smart00408
Location:524 → 579

IGc2; Immunoglobulin C-2 Type

smart00410
Location:321 → 402

IG_like; Immunoglobulin like

cd00063
Location:995 → 1092

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:236 → 311

I-set; Immunoglobulin I-set domain

pfam00041
Location:1199 → 1282

fn3; Fibronectin type III domain

cd00096
Location:1312 → 1377

Ig; Immunoglobulin domain

cl11960
Location:805 → 898

Ig; Immunoglobulin domain

cl28434
Location:408 → 502

I-set; Immunoglobulin I-set domain
XM_005155472.3 → XP_005155529.1 Down syndrome cell adhesion molecule a isoform X2

UniProtKB/TrEMBL

A0A8M2B246

Conserved Domains (8) summary

cd00096
Location:802 → 867

Ig; Immunoglobulin domain

cd05734
Location:198 → 277

Ig7_DSCAM; Seventh immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM)

smart00408
Location:14 → 69

IGc2; Immunoglobulin C-2 Type

smart00410
Location:99 → 177

IG_like; Immunoglobulin like

cd00063
Location:485 → 582

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:2 → 86

I-set; Immunoglobulin I-set domain

pfam00041
Location:590 → 676

fn3; Fibronectin type III domain

cl11960
Location:295 → 388

Ig; Immunoglobulin domain