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FEM1C fem-1 homolog C [ Homo sapiens (human) ]

Gene ID: 56929, updated on 11-Apr-2024

Summary

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Official Symbol
FEM1Cprovided by HGNC
Official Full Name
fem-1 homolog Cprovided by HGNC
Primary source
HGNC:HGNC:16933
See related
Ensembl:ENSG00000145780 MIM:608767; AllianceGenome:HGNC:16933
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FEM1A; EUROIMAGE686608; EUROIMAGE783647
Summary
Enables ubiquitin ligase-substrate adaptor activity. Involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Located in cytosol and nucleoplasm. Part of Cul2-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 24.9), testis (RPKM 9.4) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
5q22.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (115520908..115544775, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (116033707..116057577, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (114856605..114880472, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene COX assembly mitochondrial protein homolog Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22932 Neighboring gene chaperonin containing TCP1 subunit 5 pseudogene 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:114880021-114880787 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22934 Neighboring gene TMED7-TICAM2 readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16252 Neighboring gene TIR domain containing adaptor molecule 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:114937526-114938048 Neighboring gene TICAM2 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16254 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22936 Neighboring gene transmembrane p24 trafficking protein 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Tolerance Biomarkers in Liver Transplantation: Independent External Validation of the Predictive Strength of SENP6 and FEM1C Gene Expression. Pérez-Sanz F, et al. Transplantation, 2019 Sep. PMID 30720688
  2. C-Terminal End-Directed Protein Elimination by CRL2 Ubiquitin Ligases. Lin HC, et al. Mol Cell, 2018 May 17. PMID 29775578, Free PMC Article
  3. FEM1A and FEM1B: novel candidate genes for polycystic ovary syndrome. Goodarzi MO, et al. Hum Reprod, 2008 Dec. PMID 18757445, Free PMC Article
  4. The Fem1c genes: conserved members of the Fem1 gene family in vertebrates. Ventura-Holman T, et al. Gene, 2003 Sep 18. PMID 14527725
  5. Identification of human FEM1A, the ortholog of a C. elegans sex-differentiation gene. Krakow D, et al. Gene, 2001 Nov 28. PMID 11733146

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Molecular basis for ubiquitin ligase CRL2(FEM1C)-mediated recognition of C-degron.
    Title: Molecular basis for ubiquitin ligase CRL2(FEM1C)-mediated recognition of C-degron.
  2. Molecular basis for arginine C-terminal degron recognition by Cul2(FEM1) E3 ligase.
    Title: Molecular basis for arginine C-terminal degron recognition by Cul2(FEM1) E3 ligase.
  3. SENP6 and FEM1C gene expression in liver transplantation predicts transplantation tolerance.
    Title: Tolerance Biomarkers in Liver Transplantation: Independent External Validation of the Predictive Strength of SENP6 and FEM1C Gene Expression.
  4. FEM1 proteins are ancient regulators of Stem-Loop Binding Protein.
    Title: FEM1 proteins are ancient regulators of SLBP degradation.
  5. Observational study of gene-disease association. (HuGE Navigator)
    Title: FEM1A and FEM1B: novel candidate genes for polycystic ovary syndrome.
  6. The identification of a human homolog of this conserved gene suggests a potential role for this sex-determining molecule in humans.
    Title: Identification of human FEM1A, the ortholog of a C. elegans sex-differentiation gene.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1785

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin-like ligase-substrate adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein fem-1 homolog C
Names
FEM1-gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020177.3 → NP_064562.1  protein fem-1 homolog C

    See identical proteins and their annotated locations for NP_064562.1

    Status: VALIDATED

    Source sequence(s)
    AB058688, AC008628, BC028369, W07603
    Consensus CDS
    CCDS4118.1
    UniProtKB/Swiss-Prot
    B2RE47, Q8N3V8, Q96JP0, Q9H704, Q9NPL6, Q9NPL9
    Related
    ENSP00000274457.3, ENST00000274457.5
    Conserved Domains (4) summary
    PHA02876
    Location:164 → 568
    PHA02876; ankyrin repeat protein; Provisional
    COG0666
    Location:462 → 599
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:118 → 146
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:87 → 178
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    115520908..115544775 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    116033707..116057577 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96JP0.1 GenPept UniProtKB/Swiss-Prot:Q96JP0

Gene LinkOut

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