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GL50803_0093938 Triosephosphate isomerase, cytosolic [ Giardia intestinalis ]

Gene ID: 5699725, updated on 17-May-2024

Summary

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Gene symbol
GL50803_0093938
Gene description
Triosephosphate isomerase, cytosolic
Primary source
GiardiaDB:GL50803_0093938
Locus tag
GL50803_0093938
See related
VEuPathDB:GL50803_0093938
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Giardia intestinalis (strain: WB C6, culture-collection: ATCC:50803)
Lineage
Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia
Old locus tag
GL50803_93938
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Genomic context

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See GL50803_0093938 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
1
Sequence:
Chromosome: 5; NC_051860.1 (2891129..2891902)

Chromosome 5 - NC_051860.1Genomic Context describing neighboring genes Neighboring gene Kinase, AGC PKA Neighboring gene hypothetical protein Neighboring gene 5' nucleotidase family protein Neighboring gene Cathepsin L

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_051860.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Determining the molecular mechanism of inactivation by chemical modification of triosephosphate isomerase from the human parasite Giardia lamblia: a study for antiparasitic drug design. Enríquez-Flores S, et al. Proteins, 2011 Sep. PMID 21786322
  2. A theoretical study to establish the relationship between the three-dimensional structure of triose-phosphate isomerase of Giardia duodenalis and point mutations in the respective gene. Nolan MJ, et al. Mol Cell Probes, 2010 Oct. PMID 20561582
  3. Giardia spp. Are Commonly Found in Mixed Assemblages in Surface Water, as Revealed by Molecular and Whole-Genome Characterization. Prystajecky N, et al. Appl Environ Microbiol, 2015 Jul. PMID 25956776, Free PMC Article
  4. Genomic minimalism in the early diverging intestinal parasite Giardia lamblia. Morrison HG, et al. Science, 2007 Sep 28. PMID 17901334

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study found that the Cys222 derivatization is responsible for G. lamblia triosephosphate isomerase (GlTIM) inactivation.
    Title: Determining the molecular mechanism of inactivation by chemical modification of triosephosphate isomerase from the human parasite Giardia lamblia: a study for antiparasitic drug design.
  2. Data show that amino acid substitutions arising from codon variations were mainly located at surface-accessible sites or in hydrophobic pockets of triose-phosphate isomerase.
    Title: A theoretical study to establish the relationship between the three-dimensional structure of triose-phosphate isomerase of Giardia duodenalis and point mutations in the respective gene.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables triose-phosphate isomerase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in gluconeogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in glyceraldehyde-3-phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in glycerol catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
Triosephosphate isomerase, cytosolic

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_051860.1 Reference assembly

    Range
    2891129..2891902
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001706778.1 → XP_001706830.1  Triosephosphate isomerase, cytosolic [Giardia intestinalis]

    See identical proteins and their annotated locations for XP_001706830.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P36186
    UniProtKB/TrEMBL
    A0A0F6PNL6, A8BIF2, Q27658
    Conserved Domains (1) summary
    PTZ00333
    Location:1 → 256
    PTZ00333; triosephosphate isomerase; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36186.1

Gene LinkOut

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Molecular Biology Databases
Research Materials