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pik3c2a phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha [ Danio rerio (zebrafish) ]

Gene ID: 571356, updated on 11-Apr-2024

Summary

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Official Symbol
pik3c2aprovided by ZNC
Official Full Name
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alphaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030328-39
See related
Ensembl:ENSDARG00000060841 AllianceGenome:ZFIN:ZDB-GENE-030328-39
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sb:cb156; wu:fc02a04; si:dkey-24l11.7
Summary
Predicted to enable 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Acts upstream of or within angiogenesis. Predicted to be part of phosphatidylinositol 3-kinase complex. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including axis; heart tube; nervous system; notochord; and pectoral fin musculature. Orthologous to human PIK3C2A (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 18
Exon count:
34
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (27001065..27073137)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (27018705..27090752)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene proline-serine-threonine phosphatase interacting protein 1a Neighboring gene reticulocalbin 2 Neighboring gene protein phosphatase 1, regulatory subunit 15B Neighboring gene pleckstrin homology domain containing, family A member 7a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation. Gulluni F, et al. Science, 2021 Dec 10. PMID 34882480, Free PMC Article
  2. Zebrafish WNK lysine deficient protein kinase 1 (wnk1) affects angiogenesis associated with VEGF signaling. Lai JG, et al. PLoS One, 2014. PMID 25171174, Free PMC Article
  3. Interferon-independent antiviral activity of 25-hydroxycholesterol in a teleost fish. Pereiro P, et al. Antiviral Res, 2017 Sep. PMID 28789986
  4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation.
    Title: PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol-3-phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of phosphatidylinositol 3-kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
Names
phosphoinositide-3-kinase, class 2, alpha polypeptide
XP_005159362.2
XP_005159363.2
XP_021323495.1
XP_021323496.1
XP_021323497.1
XP_021330104.1
XP_021330105.1
XP_021330106.1
XP_700029.5

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    27001065..27073137
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021467820.1 → XP_021323495.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8M9PQU0
    Related
    ENSDARP00000120821.1, ENSDART00000133547.2
    Conserved Domains (7) summary
    cd07289
    Location:1428 → 1536
    PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:681 → 852
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd08381
    Location:1565 → 1686
    C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    pfam00794
    Location:420 → 507
    PI3K_rbd; PI3-kinase family, ras-binding domain
    cl00271
    Location:872 → 1038
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
    cl21453
    Location:1045 → 1397
    PKc_like; Protein Kinases, catalytic domain
    cl25716
    Location:137 → 207
    Amelogenin; Amelogenin

  2. XM_021467822.1 → XP_021323497.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A8M9P1D7, F6NMW9
    Related
    ENSDARP00000080566.5, ENSDART00000086131.6
    Conserved Domains (7) summary
    cd07289
    Location:1422 → 1530
    PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:675 → 846
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd08381
    Location:1559 → 1680
    C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    pfam00794
    Location:420 → 507
    PI3K_rbd; PI3-kinase family, ras-binding domain
    cl00271
    Location:866 → 1032
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
    cl21453
    Location:1039 → 1391
    PKc_like; Protein Kinases, catalytic domain
    cl25716
    Location:137 → 207
    Amelogenin; Amelogenin

  3. XM_021467821.1 → XP_021323496.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8M9PQU0
    Conserved Domains (7) summary
    cd07289
    Location:1428 → 1536
    PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:681 → 852
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd08381
    Location:1565 → 1686
    C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    pfam00794
    Location:420 → 507
    PI3K_rbd; PI3-kinase family, ras-binding domain
    cl00271
    Location:872 → 1038
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
    cl21453
    Location:1045 → 1397
    PKc_like; Protein Kinases, catalytic domain
    cl25716
    Location:137 → 207
    Amelogenin; Amelogenin

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395030.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    181391..256038
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005159305.4 → XP_005159362.2  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8M2B5U1
    Conserved Domains (7) summary
    cd07289
    Location:1428 → 1536
    PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:681 → 852
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd08381
    Location:1565 → 1686
    C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    pfam00794
    Location:420 → 507
    PI3K_rbd; PI3-kinase family, ras-binding domain
    cl00271
    Location:872 → 1038
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
    cl21453
    Location:1045 → 1397
    PKc_like; Protein Kinases, catalytic domain
    cl25716
    Location:137 → 207
    Amelogenin

  2. XM_694937.8 → XP_700029.5  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A2R8QSP1, A0A8N7T897
    Conserved Domains (7) summary
    cd07289
    Location:1422 → 1530
    PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:675 → 846
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd08381
    Location:1559 → 1680
    C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    pfam00794
    Location:420 → 507
    PI3K_rbd; PI3-kinase family, ras-binding domain
    cl00271
    Location:866 → 1032
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
    cl21453
    Location:1039 → 1391
    PKc_like; Protein Kinases, catalytic domain
    cl25716
    Location:137 → 207
    Amelogenin

  3. XM_005159306.3 → XP_005159363.2  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8M2B5U1
    Conserved Domains (7) summary
    cd07289
    Location:1428 → 1536
    PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:681 → 852
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd08381
    Location:1565 → 1686
    C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    pfam00794
    Location:420 → 507
    PI3K_rbd; PI3-kinase family, ras-binding domain
    cl00271
    Location:872 → 1038
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
    cl21453
    Location:1045 → 1397
    PKc_like; Protein Kinases, catalytic domain
    cl25716
    Location:137 → 207
    Amelogenin

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395342.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    525199..584853
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021474429.1 → XP_021330104.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X3

    UniProtKB/TrEMBL
    A0A8M9PYW4
    Conserved Domains (5) summary
    cd04012
    Location:681 → 852
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    pfam00794
    Location:420 → 507
    PI3K_rbd; PI3-kinase family, ras-binding domain
    cl00271
    Location:872 → 1038
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
    cl21453
    Location:1045 → 1185
    PKc_like; Protein Kinases, catalytic domain
    cl25716
    Location:137 → 207
    Amelogenin

  2. XM_021474431.1 → XP_021330106.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X4

    UniProtKB/TrEMBL
    A0A8M9Q547
    Conserved Domains (5) summary
    cd04012
    Location:675 → 846
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    pfam00794
    Location:420 → 507
    PI3K_rbd; PI3-kinase family, ras-binding domain
    cl00271
    Location:866 → 1032
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
    cl21453
    Location:1039 → 1179
    PKc_like; Protein Kinases, catalytic domain
    cl25716
    Location:137 → 207
    Amelogenin

  3. XM_021474430.1 → XP_021330105.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X3

    UniProtKB/TrEMBL
    A0A8M9PYW4
    Conserved Domains (5) summary
    cd04012
    Location:681 → 852
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    pfam00794
    Location:420 → 507
    PI3K_rbd; PI3-kinase family, ras-binding domain
    cl00271
    Location:872 → 1038
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
    cl21453
    Location:1045 → 1185
    PKc_like; Protein Kinases, catalytic domain
    cl25716
    Location:137 → 207
    Amelogenin
Nucleotide Protein Strain
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