adamts2a ADAM metallopeptidase with thrombospondin type 1 motif, 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: adamts2aprovided by ZNC
Official Full Name: ADAM metallopeptidase with thrombospondin type 1 motif, 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070816-3
See related: Ensembl:ENSDARG00000075930 AllianceGenome:ZFIN:ZDB-GENE-070816-3
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: adamts2; adamts22
Summary: Predicted to enable metalloendopeptidase activity. Predicted to be involved in extracellular matrix organization. Predicted to act upstream of or within proteolysis. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Is expressed in several structures, including digestive system; eye; heart; pleuroperitoneal region; and thymus. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome and Ehlers-Danlos syndrome dermatosparaxis type. Orthologous to human ADAMTS2 (ADAM metallopeptidase with thrombospondin type 1 motif 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 21

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (32509215..32684839, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (32476246..32651530, complement)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within extracellular matrix organization	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: A disintegrin and metalloproteinase with thrombospondin motifs 2

Names: ADAM metallopeptidase with thrombospondin type 1 motif, 2; ADAM metallopeptidase with thrombospondin type 1 motif, 22; ADAMTS2/3

XP_021329110.1

EC 3.4.24.14

XP_700384.3

EC 3.4.24.14

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007132.7 Reference GRCz11 Primary Assembly

Range

32509215..32684839 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_695292.6 → XP_700384.3 A disintegrin and metalloproteinase with thrombospondin motifs 2 isoform X1

UniProtKB/TrEMBL

A0A0R4ISF7, A0A8N7URH1

Related

ENSDARP00000139103.2, ENSDART00000162873.2

Conserved Domains (6) summary

smart00209
Location:546 → 597

TSP1; Thrombospondin type 1 repeats

cd04273
Location:249 → 449

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01421
Location:250 → 452

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:79 → 193

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:705 → 818

ADAM_spacer1; ADAM-TS Spacer 1

pfam08686
Location:1039 → 1070

PLAC; PLAC (protease and lacunin) domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

NW_018395094.1 Reference GRCz11 ALT_DRER_TU_1

Range

17994..22633 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021473435.1 → XP_021329110.1 A disintegrin and metalloproteinase with thrombospondin motifs 2 isoform X2

UniProtKB/TrEMBL

A0A8M9Q7A9

Conserved Domains (1) summary

pfam01562
Location:81 → 157

Pep_M12B_propep; Reprolysin family propeptide