Vav3 vav 3 oncogene [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Vav3provided by MGI
Official Full Name: vav 3 oncogeneprovided by MGI
Primary source: MGI:MGI:1888518
See related: Ensembl:ENSMUSG00000033721 AllianceGenome:MGI:1888518
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Idd18.1; A530094I06Rik
Summary: Enables epidermal growth factor receptor binding activity and guanyl-nucleotide exchange factor activity. Acts upstream of or within several processes, including integrin-mediated signaling pathway; neutrophil chemotaxis; and positive regulation of phosphatidylinositol 3-kinase activity. Located in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; limb segment; metanephros; and sensory organ. Orthologous to human VAV3 (vav guanine nucleotide exchange factor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in whole brain E14.5 (RPKM 2.7), CNS E14 (RPKM 2.5) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F3; 3 48.13 cM

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (109247757..109593010)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (109340465..109685694)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function.
Title: The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function.
HDAC1 promotes artery injury through activation of VAV3 by binding to miR-182-5p in atherosclerotic mice model.
Title: HDAC1 promotes artery injury through activation of VAV3 by binding to miR-182-5p in atherosclerotic mice model.
Deletion of the Nucleotide Exchange Factor Vav3 Enhances Axonal Complexity and Synapse Formation but Tampers Activity of Hippocampal Neuronal Networks In Vitro.
Title: Deletion of the Nucleotide Exchange Factor Vav3 Enhances Axonal Complexity and Synapse Formation but Tampers Activity of Hippocampal Neuronal Networks In Vitro.
Inactivation of Vav3 in vivo resulted in increased vascular leakage, highlighting its function as a key regulator of barrier stability.
Title: Vav3-induced cytoskeletal dynamics contribute to heterotypic properties of endothelial barriers.
This study highlights Vav3 as a novel regulator of oligodendrocyte maturation and remyelination, suggesting that manipulation of the Vav3-dependent signaling pathway could help to improve myelin repair.
Title: The guanine nucleotide exchange factor Vav3 modulates oligodendrocyte precursor differentiation and supports remyelination in white matter lesions.
we identified novel transcriptional targets of KLF6 in HCC cells including VAV3, a known activator of the RAC1 small GTPase. Indeed, RAC1 activity is increased in KLF6-knockdown cells in a VAV3-dependent manner, and knockdown of either RAC1 or VAV3 impairs HCC cell migration. Together, our data demonstrate a novel function for KLF6 in constraining HCC dissemination through the regulation of a VAV3-RAC1 signaling axis.
Title: A novel KLF6-Rho GTPase axis regulates hepatocellular carcinoma cell migration and dissemination.
Vav3 is a regulator of retinal progenitor cell differentiation, thus highlighting a novel role for guanine nucleotide exchange factors in retinogenesis.
Title: The guanine nucleotide exchange factor Vav3 regulates differentiation of progenitor cells in the developing mouse retina.
Platelet P-Rex and Vav family Rac-GEFs play important proinflammatory roles in leukocyte recruitment.
Title: P-Rex and Vav Rac-GEFs in platelets control leukocyte recruitment to sites of inflammation.
chow diet-fed Vav3 knockout mice develop an incomplete postreceptor insulin state characterized by typical liver and plasma metabolic syndrome-like pathophysiologies that is not associated to other defects such as white adipocyte hypertrophy and obesity
Title: Chronic sympathoexcitation through loss of Vav3, a Rac1 activator, results in divergent effects on metabolic syndrome and obesity depending on diet.
Data demonstrate that the co-expression of the exchange factors Vav2 and Vav3 is critical for the development of this tumor type.
Title: The Rho exchange factors Vav2 and Vav3 favor skin tumor initiation and promotion by engaging extracellular signaling loops.

Submit: New GeneRIF Correction See all GeneRIFs (34)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
QTL (2) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA986410 (e-PCR)
- UniSTS:163330

D3Mit158 (e-PCR), detects polymorphism
- UniSTS:129571

AU048068 (e-PCR)
- UniSTS:109904

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables epidermal growth factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables guanyl-nucleotide exchange factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell projection assembly	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within integrin-mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lamellipodium assembly	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neutrophil chemotaxis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of B cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell adhesion	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of GTPase activity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within small GTPase-mediated signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vesicle fusion	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in immunological synapse	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: guanine nucleotide exchange factor VAV3

Names: VAV-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001378987.1 → NP_001365916.1 guanine nucleotide exchange factor VAV3 isoform 3

Status: VALIDATED

Source sequence(s)

AL671857, AL671987, AL731716

Conserved Domains (7) summary

cd10407
Location:666 → 768

SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins

cd11978
Location:819 → 874

SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein

cd11981
Location:596 → 657

SH3_VAV3_1; First Src homology 3 domain of VAV3 protein

cd00160
Location:193 → 369

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd01223
Location:383 → 506

PH_Vav; Vav pleckstrin homology (PH) domain

cd21264
Location:2 → 118

CH_VAV3; calponin homology (CH) domain found in VAV3 protein and similar proteins

cd20869
Location:506 → 564

C1_VAV3; protein kinase C conserved region 1 (C1 domain) found in VAV3 protein
NM_020505.2 → NP_065251.2 guanine nucleotide exchange factor VAV3 isoform 1

See identical proteins and their annotated locations for NP_065251.2

Status: VALIDATED

Source sequence(s)

AF067816, AK033253, BC052739

Consensus CDS

CCDS17773.1

UniProtKB/Swiss-Prot

A2CFD7, Q7TS85, Q8BRV2, Q8CCF5, Q8R076, Q9JLS6, Q9R0C8

Related

ENSMUSP00000036270.8, ENSMUST00000046864.14

Conserved Domains (8) summary

cd10407
Location:666 → 768

SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins

cd11978
Location:791 → 846

SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein

cd11981
Location:596 → 657

SH3_VAV3_1; First Src homology 3 domain of VAV3 protein

cd00029
Location:514 → 561

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00160
Location:193 → 369

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd01223
Location:383 → 506

PH_Vav; Vav pleckstrin homology (PH) domain

pfam00169
Location:407 → 502

PH; PH domain

pfam11971
Location:18 → 103

CAMSAP_CH; CAMSAP CH domain
NM_146139.2 → NP_666251.1 guanine nucleotide exchange factor VAV3 isoform 2

See identical proteins and their annotated locations for NP_666251.1

Status: VALIDATED

Source sequence(s)

AF140280, BC052739

Consensus CDS

CCDS59650.1

UniProtKB/Swiss-Prot

Q9R0C8

Related

ENSMUSP00000102186.3, ENSMUST00000106576.3

Conserved Domains (3) summary

cd10407
Location:106 → 208

SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins

cd11978
Location:231 → 286

SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein

cd11981
Location:36 → 97

SH3_VAV3_1; First Src homology 3 domain of VAV3 protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

109247757..109593010

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006501820.5 → XP_006501883.1 guanine nucleotide exchange factor VAV3 isoform X1

See identical proteins and their annotated locations for XP_006501883.1

Conserved Domains (7) summary

cd10407
Location:642 → 744

SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins

cd11978
Location:795 → 850

SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein

cd11981
Location:572 → 633

SH3_VAV3_1; First Src homology 3 domain of VAV3 protein

cd00029
Location:514 → 561

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00160
Location:193 → 369

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd01223
Location:383 → 506

PH_Vav; Vav pleckstrin homology (PH) domain

pfam11971
Location:18 → 103

CAMSAP_CH; CAMSAP CH domain
XM_036163196.1 → XP_036019089.1 guanine nucleotide exchange factor VAV3 isoform X2

Conserved Domains (7) summary

cd10407
Location:642 → 744

SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins

cd11978
Location:767 → 822

SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein

cd11981
Location:572 → 633

SH3_VAV3_1; First Src homology 3 domain of VAV3 protein

cd00160
Location:193 → 369

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd01223
Location:383 → 506

PH_Vav; Vav pleckstrin homology (PH) domain

cd21264
Location:2 → 118

CH_VAV3; calponin homology (CH) domain found in VAV3 protein and similar proteins

cd20869
Location:506 → 564

C1_VAV3; protein kinase C conserved region 1 (C1 domain) found in VAV3 protein