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Or4e5 olfactory receptor family 4 subfamily E member 5 [ Mus musculus (house mouse) ]

Gene ID: 57269, updated on 11-Apr-2024

Summary

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Official Symbol
Or4e5provided by MGI
Official Full Name
olfactory receptor family 4 subfamily E member 5provided by MGI
Primary source
MGI:MGI:3031341
See related
Ensembl:ENSMUSG00000059887 AllianceGenome:MGI:3031341
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Or28; Mor28; MOR244-1; Olfr1507
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
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Genomic context

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See Or4e5 in Genome Data Viewer
Location:
14 C2; 14 26.97 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (52727392..52733152, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (52489935..52495695, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 4 subfamily E member 2 Neighboring gene T cell receptor alpha chain Neighboring gene predicted gene, 36382 Neighboring gene olfactory receptor family 4 subfamily E member 1 Neighboring gene enolase 1, alpha non-neuron pseudogene Neighboring gene predicted gene, 36448 Neighboring gene ATPase, H+ transporting, lysosomal accessory protein 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Odorant receptors on axon termini in the brain. Barnea G, et al. Science, 2004 Jun 4. PMID 15178793
  2. Monoallelic expression of the odourant receptor gene and axonal projection of olfactory sensory neurones. Ishii T, et al. Genes Cells, 2001 Jan. PMID 11277098
  3. Dnmt3a regulates global gene expression in olfactory sensory neurons and enables odorant-induced transcription. Colquitt BM, et al. Neuron, 2014 Aug 20. PMID 25123312, Free PMC Article
  4. Neuropilin-2 is required for the proper targeting of ventral glomeruli in the mouse olfactory bulb. Takahashi H, et al. Mol Cell Neurosci, 2010 Jul. PMID 20363325
  5. Odorant receptor proteins in the mouse main olfactory epithelium and olfactory bulb. Low VF, et al. Neuroscience, 2017 Mar 6. PMID 28057532

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. identifed an upstream cis-acting DNA region that activates the OR gene cluster in mouse and allows the expression of only one OR gene within the cluster
    Title: Negative feedback regulation ensures the one receptor-one olfactory neuron rule in mouse.
  2. localized to the axon terminus in the olfactory bulb
    Title: Odorant receptors on axon termini in the brain.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables odorant binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables olfactory receptor activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISA
Inferred from Sequence Alignment
more info
 PubMed 
involved_in detection of chemical stimulus involved in sensory perception of smell IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sensory perception of smell ISA
Inferred from Sequence Alignment
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane ISA
Inferred from Sequence Alignment
more info
 PubMed 

General protein information

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Preferred Names
olfactory receptor 1507
Names
GA_x6K02T2RJGY-491851-492792
gene for odorant receptor MOR28
olfactory receptor MOR244-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007044.1 

    Range
    62469..68229 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001170918.1 → NP_001164389.1  olfactory receptor 1507

    See identical proteins and their annotated locations for NP_001164389.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC119165, CB173597, CB174012
    Consensus CDS
    CCDS27062.1
    UniProtKB/TrEMBL
    A0A0U1RPW5, F7C854, Q0VEP0, Q9R0K5
    Related
    ENSMUSP00000146152.4, ENSMUST00000206062.4
    Conserved Domains (2) summary
    pfam00001
    Location:44 → 290
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:34 → 308
    7tm_4; Olfactory receptor

  2. NM_020512.2 → NP_065258.2  olfactory receptor 1507

    See identical proteins and their annotated locations for NP_065258.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different segment for its 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC119165
    Consensus CDS
    CCDS27062.1
    UniProtKB/TrEMBL
    A0A0U1RPW5, F7C854, Q0VEP0, Q9R0K5
    Related
    ENSMUSP00000073260.6, ENSMUST00000073571.6
    Conserved Domains (2) summary
    pfam00001
    Location:44 → 290
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:34 → 308
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    52727392..52733152 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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