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Cnr2 cannabinoid receptor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 57302, updated on 13-Apr-2024

Summary

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Official Symbol
Cnr2provided by RGD
Official Full Name
cannabinoid receptor 2provided by RGD
Primary source
RGD:619713
See related
Ensembl:ENSRNOG00000009260 AllianceGenome:RGD:619713
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CB2; CB-2; CB2C; CNR2C
Summary
Enables cannabinoid receptor activity. Involved in several processes, including negative regulation of GABAergic synaptic transmission; negative regulation of mast cell activation; and negative regulation of nitric-oxide synthase activity. Located in dendrite and neuronal cell body. Is extrinsic component of cytoplasmic side of plasma membrane. Used to study Huntington's disease; arthritis; and sciatic neuropathy. Biomarker of pancreatitis. Orthologous to human CNR2 (cannabinoid receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 203.0), Lung (RPKM 25.2) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cnr2 in Genome Data Viewer
Location:
5q36
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (153408968..153435092)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (148125222..148151548)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (154242010..154268126)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene serine and arginine rich splicing factor 10 Neighboring gene proline-rich nuclear receptor coactivator 2 Neighboring gene alpha-L-fucosidase 1 Neighboring gene 3-hydroxy-3-methylglutaryl-CoA lyase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. [Activation of cannabinoid receptor 2 alleviates acute lung injury in rats with lipopolysaccharide-induced sepsis]. Kang H, et al. Nan Fang Yi Ke Da Xue Xue Bao, 2022 Sep 20. PMID 36210711, Free PMC Article
  2. CB2 receptors modulate seizure-induced expression of pro-inflammatory cytokines in the hippocampus but not neocortex. Karan AA, et al. Mol Neurobiol, 2021 Aug. PMID 33907944
  3. CB2 Receptors and Neuron-Glia Interactions Modulate Neurotoxicity Generated by MAGL Inhibition. Rojo-Bustamante E, et al. Biomolecules, 2020 Aug 18. PMID 32824740, Free PMC Article
  4. CB2R induces a protective response against epileptic seizures through ERK and p38 signaling pathways. Cao Q, et al. Int J Neurosci, 2021 Aug. PMID 32715907
  5. Cannabinoid CB(2) receptors mediate the anxiolytic-like effects of monoacylglycerol lipase inhibition in a rat model of predator-induced fear. Ivy D, et al. Neuropsychopharmacology, 2020 Jul. PMID 32375160, Free PMC Article

See all (106) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of a novel fatty acid binding protein-5-CB2 receptor-dependent mechanism regulating anxiety behaviors in the prefrontal cortex.
    Title: Identification of a novel fatty acid binding protein-5-CB2 receptor-dependent mechanism regulating anxiety behaviors in the prefrontal cortex.
  2. [Activation of cannabinoid receptor 2 alleviates acute lung injury in rats with lipopolysaccharide-induced sepsis].
    Title: [Activation of cannabinoid receptor 2 alleviates acute lung injury in rats with lipopolysaccharide-induced sepsis].
  3. CB2 receptors modulate seizure-induced expression of pro-inflammatory cytokines in the hippocampus but not neocortex.
    Title: CB2 receptors modulate seizure-induced expression of pro-inflammatory cytokines in the hippocampus but not neocortex.
  4. CB2R induces a protective response against epileptic seizures through ERK and p38 signaling pathways.
    Title: CB2R induces a protective response against epileptic seizures through ERK and p38 signaling pathways.
  5. Altered cannabinoid receptor expression in pancreatic islets in experimental model of uraemia.
    Title: Altered cannabinoid receptor expression in pancreatic islets in experimental model of uraemia.
  6. Cannabinoid CB2 receptors mediate the anxiolytic-like effects of monoacylglycerol lipase inhibition in a rat model of predator-induced fear.
    Title: Cannabinoid CB(2) receptors mediate the anxiolytic-like effects of monoacylglycerol lipase inhibition in a rat model of predator-induced fear.
  7. CB2 Receptors and Neuron-Glia Interactions Modulate Neurotoxicity Generated by MAGL Inhibition.
    Title: CB2 Receptors and Neuron-Glia Interactions Modulate Neurotoxicity Generated by MAGL Inhibition.
  8. Cannabinoid Receptors Overexpression in a Rat Model of Irritable Bowel Syndrome (IBS) after Treatment with a Ketogenic Diet.
    Title: Cannabinoid Receptors Overexpression in a Rat Model of Irritable Bowel Syndrome (IBS) after Treatment with a Ketogenic Diet.
  9. JWH133 inhibits MPP(+)-induced inflammatory response and iron influx in astrocytes.
    Title: JWH133 inhibits MPP(+)-induced inflammatory response and iron influx in astrocytes.
  10. Antinociceptive effects of treadmill exercise in a rat model of Parkinson's disease: The role of cannabinoid and opioid receptors.
    Title: Antinociceptive effects of treadmill exercise in a rat model of Parkinson's disease: The role of cannabinoid and opioid receptors.
Submit: New GeneRIF Correction See all GeneRIFs (90)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cannabinoid receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cannabinoid receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cannabinoid signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within leukocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of action potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of mast cell activation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of synaptic transmission, GABAergic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to amphetamine IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in extrinsic component of cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cannabinoid receptor 2
Names
CB2 receptor
cannabinoid receptor 2 (macrophage)
peripheral cannabinoid receptor
rCB2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164142.3 → NP_001157614.1  cannabinoid receptor 2 isoform 1

    See identical proteins and their annotated locations for NP_001157614.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    BC107941, FJ694960, JAXUCZ010000005
    UniProtKB/Swiss-Prot
    Q9EP74, Q9QZN9
    UniProtKB/TrEMBL
    C6G964, C6G965
    Related
    ENSRNOP00000066697.1, ENSRNOT00000074998.3
    Conserved Domains (1) summary
    cd15341
    Location:34 → 310
    7tmA_CB2; cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001164143.3 → NP_001157615.1  cannabinoid receptor 2 isoform 1

    See identical proteins and their annotated locations for NP_001157615.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the shorter isoform (1). Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC107941, FJ694961, JAXUCZ010000005
    UniProtKB/Swiss-Prot
    Q9EP74, Q9QZN9
    UniProtKB/TrEMBL
    C6G964, C6G965
    Related
    ENSRNOP00000078684.1, ENSRNOT00000114527.1
    Conserved Domains (1) summary
    cd15341
    Location:34 → 310
    7tmA_CB2; cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. NM_020543.4 → NP_065418.3  cannabinoid receptor 2 isoform 2

    See identical proteins and their annotated locations for NP_065418.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences in the coding region compared to variant 1. The resulting protein (isoform 2) is longer and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A6IT74
    Related
    ENSRNOP00000012342.2, ENSRNOT00000012342.5
    Conserved Domains (1) summary
    cd15341
    Location:34 → 310
    7tmA_CB2; cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    153408968..153435092
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063288330.1 → XP_063144400.1  cannabinoid receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9EP74, Q9QZN9
    UniProtKB/TrEMBL
    C6G964, C6G965

  2. XM_063288329.1 → XP_063144399.1  cannabinoid receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9EP74, Q9QZN9
    UniProtKB/TrEMBL
    C6G964, C6G965

  3. XM_039110690.2 → XP_038966618.1  cannabinoid receptor 2 isoform X2

    UniProtKB/TrEMBL
    A6IT74
    Conserved Domains (1) summary
    cd15341
    Location:34 → 310
    7tmA_CB2; cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RNA

  1. XR_010066464.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QZN9.3 GenPept UniProtKB/Swiss-Prot:Q9QZN9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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