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ZNF286A zinc finger protein 286A [ Homo sapiens (human) ]

Gene ID: 57335, updated on 7-Apr-2024

Summary

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Official Symbol
ZNF286Aprovided by HGNC
Official Full Name
zinc finger protein 286Aprovided by HGNC
Primary source
HGNC:HGNC:13501
See related
Ensembl:ENSG00000187607 AllianceGenome:HGNC:13501
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF286
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be integral component of membrane. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 4.0), endometrium (RPKM 3.2) and 24 other tissues See more
Orthologs
all
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Genomic context

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Location:
17p12
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (15699752..15720787)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (15605992..15627027)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (15603066..15624101)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene proximal CMT1A-REP Neighboring gene F-box and WD repeat domain containing 10B Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr17:15495673-15496196 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:15545644-15546230 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:15546231-15546817 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:15547662-15548477 Neighboring gene tripartite motif containing 16 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11743 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:15554223-15555172 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:15562775-15563277 Neighboring gene ZNF286A-TBC1D26 readthrough (NMD candidate) Neighboring gene zinc finger protein 29, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:15602763-15603374 Neighboring gene ubiquitin conjugating enzyme E2 S pseudogene 1 Neighboring gene TBC1D26 antisense RNA 1 Neighboring gene uncharacterized LOC105371559 Neighboring gene TBC1 domain family member 26

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Isolation of novel genes from the CMT1A duplication/HNPP deletion critical region in 17p11.2-p12. Murakami T, et al. Genomics, 1997 Jan 1. PMID 9027492
  2. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 2001 Apr 27. PMID 11347906
  3. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. Nakajima D, et al. DNA Res, 2002 Jun 30. PMID 12168954
  4. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. Kumar R, et al. Nat Commun, 2017 Nov 27. PMID 29180619, Free PMC Article
  5. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. Suzuki Y, et al. Genome Res, 2004 Sep. PMID 15342556, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1874, MGC149627, MGC156181

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 286A
Names
zinc finger protein ZNF286

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130842.2 → NP_001124314.1  zinc finger protein 286A isoform 2

    See identical proteins and their annotated locations for NP_001124314.1

    Status: VALIDATED

    Source sequence(s)
    AC005324, AF217226, AK315062, BU687070
    Consensus CDS
    CCDS11172.1
    UniProtKB/Swiss-Prot
    B4DKF9, Q96JF3, Q9HBT8
    Related
    ENSP00000464063.1, ENST00000583566.6
    Conserved Domains (6) summary
    smart00349
    Location:45 → 98
    KRAB; krueppel associated box
    COG5048
    Location:352 → 507
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:384 → 404
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:354 → 376
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:45 → 80
    KRAB; KRAB box
    pfam13465
    Location:424 → 449
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001288642.2 → NP_001275571.1  zinc finger protein 286A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC005324
    UniProtKB/Swiss-Prot
    Q9HBT8
    Conserved Domains (6) summary
    smart00349
    Location:88 → 141
    KRAB; krueppel associated box
    COG5048
    Location:395 → 550
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:427 → 447
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:397 → 419
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:88 → 123
    KRAB; KRAB box
    pfam13465
    Location:467 → 492
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001288643.2 → NP_001275572.1  zinc finger protein 286A isoform 3

    See identical proteins and their annotated locations for NP_001275572.1

    Status: VALIDATED

    Source sequence(s)
    AC005324
    Consensus CDS
    CCDS73997.1
    UniProtKB/Swiss-Prot
    Q9HBT8
    Related
    ENSP00000466154.1, ENST00000593105.5
    Conserved Domains (6) summary
    smart00349
    Location:35 → 88
    KRAB; krueppel associated box
    COG5048
    Location:342 → 497
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:374 → 394
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:344 → 366
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:35 → 70
    KRAB; KRAB box
    pfam13465
    Location:414 → 439
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001288644.2 → NP_001275573.2  zinc finger protein 286A isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC005324
    UniProtKB/TrEMBL
    A1A525
    Conserved Domains (2) summary
    COG5048
    Location:240 → 395
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:272 → 292
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. NM_001288645.2 → NP_001275574.1  zinc finger protein 286A isoform 5

    See identical proteins and their annotated locations for NP_001275574.1

    Status: VALIDATED

    Source sequence(s)
    AC005324
    UniProtKB/TrEMBL
    A1A525
    Conserved Domains (2) summary
    COG5048
    Location:240 → 395
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:272 → 292
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. NM_001288646.2 → NP_001275575.1  zinc finger protein 286A isoform 5

    See identical proteins and their annotated locations for NP_001275575.1

    Status: VALIDATED

    Source sequence(s)
    AC005324
    UniProtKB/TrEMBL
    A1A525
    Conserved Domains (2) summary
    COG5048
    Location:240 → 395
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:272 → 292
    ZF_C2H2; C2H2 Zn finger [structural motif]

  7. NM_001288647.2 → NP_001275576.1  zinc finger protein 286A isoform 5

    See identical proteins and their annotated locations for NP_001275576.1

    Status: VALIDATED

    Source sequence(s)
    AC005324
    UniProtKB/TrEMBL
    A1A525
    Conserved Domains (2) summary
    COG5048
    Location:240 → 395
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:272 → 292
    ZF_C2H2; C2H2 Zn finger [structural motif]

  8. NM_001288648.2 → NP_001275577.1  zinc finger protein 286A isoform 5

    See identical proteins and their annotated locations for NP_001275577.1

    Status: VALIDATED

    Source sequence(s)
    AC005324
    UniProtKB/TrEMBL
    A1A525
    Conserved Domains (2) summary
    COG5048
    Location:240 → 395
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:272 → 292
    ZF_C2H2; C2H2 Zn finger [structural motif]

  9. NM_001288649.2 → NP_001275578.1  zinc finger protein 286A isoform 5

    See identical proteins and their annotated locations for NP_001275578.1

    Status: VALIDATED

    Source sequence(s)
    AC005324
    UniProtKB/TrEMBL
    A1A525
    Conserved Domains (2) summary
    COG5048
    Location:240 → 395
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:272 → 292
    ZF_C2H2; C2H2 Zn finger [structural motif]

  10. NM_001369436.1 → NP_001356365.1  zinc finger protein 286A isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC005324
    UniProtKB/TrEMBL
    A1A525
    Conserved Domains (2) summary
    COG5048
    Location:240 → 395
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:272 → 292
    ZF_C2H2; C2H2 Zn finger [structural motif]

  11. NM_001369437.1 → NP_001356366.1  zinc finger protein 286A isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC005324
    UniProtKB/TrEMBL
    A1A525
    Conserved Domains (2) summary
    COG5048
    Location:240 → 395
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:272 → 292
    ZF_C2H2; C2H2 Zn finger [structural motif]

  12. NM_001369438.1 → NP_001356367.1  zinc finger protein 286A isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC005324
    UniProtKB/TrEMBL
    A1A525
    Conserved Domains (2) summary
    COG5048
    Location:240 → 395
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:272 → 292
    ZF_C2H2; C2H2 Zn finger [structural motif]

  13. NM_001369440.1 → NP_001356369.1  zinc finger protein 286A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC005324
    Conserved Domains (3) summary
    smart00349
    Location:1 → 47
    KRAB; krueppel associated box
    COG5048
    Location:301 → 456
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:333 → 353
    ZF_C2H2; C2H2 Zn finger [structural motif]

  14. NM_020652.3 → NP_065703.1  zinc finger protein 286A isoform 2

    See identical proteins and their annotated locations for NP_065703.1

    Status: VALIDATED

    Source sequence(s)
    AC005324
    Consensus CDS
    CCDS11172.1
    UniProtKB/Swiss-Prot
    B4DKF9, Q96JF3, Q9HBT8
    Related
    ENSP00000397163.1, ENST00000421016.5
    Conserved Domains (6) summary
    smart00349
    Location:45 → 98
    KRAB; krueppel associated box
    COG5048
    Location:352 → 507
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:384 → 404
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:354 → 376
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:45 → 80
    KRAB; KRAB box
    pfam13465
    Location:424 → 449
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    15699752..15720787
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    15605992..15627027
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9HBT8.1 GenPept UniProtKB/Swiss-Prot:Q9HBT8

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