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Srd5a3 steroid 5 alpha-reductase 3 [ Mus musculus (house mouse) ]

Gene ID: 57357, updated on 5-Jan-2022

Summary

Official Symbol
Srd5a3provided by MGI
Official Full Name
steroid 5 alpha-reductase 3provided by MGI
Primary source
MGI:MGI:1930252
See related
Ensembl:ENSMUSG00000029233
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H5ar; S5AR 3; Srd5a2l; AV364670; AW987574; A430076C09; 1110025P14Rik; D730040M03Rik
Summary
Predicted to enable 3-oxo-5-alpha-steroid 4-dehydrogenase activity and oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor. Involved in dolichol metabolic process; dolichol-linked oligosaccharide biosynthetic process; and polyprenol catabolic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in Kahrizi syndrome and congenital disorder of glycosylation Iq. Orthologous to human SRD5A3 (steroid 5 alpha-reductase 3). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in adrenal adult (RPKM 34.2), ovary adult (RPKM 24.0) and 28 other tissues See more
Orthologs
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Genomic context

See Srd5a3 in Genome Data Viewer
Location:
5; 5 C3.3
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (76285296..76303350)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (76140273..76155503)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (76569302..76584496)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32780 Neighboring gene GABA(A) receptor-associated protein-like 2 pseudogene 5_758.1 Neighboring gene predicted gene, 33938 Neighboring gene transmembrane protein 165 Neighboring gene adenomatosis polyposis coli, pseudogene 1 Neighboring gene circadian locomotor output cycles kaput Neighboring gene ubiquitin-conjugating enzyme E2N, pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in dolichol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in dolichol metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dolichol metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in dolichol-linked oligosaccharide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in dolichol-linked oligosaccharide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dolichol-linked oligosaccharide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in polyprenol catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in polyprenol catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in polyprenol catabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
polyprenol reductase
Names
3-oxo-5-alpha-steroid 4-dehydrogenase 3
H5AR
SR type 3
probable polyprenol reductase
steroid 5 alpha-reductase 2 like
steroid 5 alpha-reductase 2-like; H5AR gene; steroid 5 alpha-reductase 2 like
NP_065636.2
XP_006535225.1
XP_036021275.1
XP_036021276.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020611.4NP_065636.2  polyprenol reductase

    See identical proteins and their annotated locations for NP_065636.2

    Status: VALIDATED

    Source sequence(s)
    AI553072, AK075635, AK164282
    Consensus CDS
    CCDS19358.1
    UniProtKB/Swiss-Prot
    Q9WUP4
    Related
    ENSMUSP00000031143.7, ENSMUST00000031143.13
    Conserved Domains (1) summary
    cl21511
    Location:51330
    PEMT; Phospholipid methyltransferase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    76285296..76303350
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165382.1XP_036021275.1  polyprenol reductase isoform X2

    Related
    ENSMUSP00000109134.2, ENSMUST00000113506.2
    Conserved Domains (1) summary
    cl21511
    Location:23213
    PEMT; Phospholipid methyltransferase
  2. XM_036165383.1XP_036021276.1  polyprenol reductase isoform X3

    Conserved Domains (1) summary
    cl21511
    Location:51192
    PEMT; Phospholipid methyltransferase
  3. XM_006535162.1XP_006535225.1  polyprenol reductase isoform X1

    Conserved Domains (1) summary
    cl21511
    Location:8263
    PEMT; Phospholipid methyltransferase
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