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hbbe1.3 hemoglobin, beta embryonic 1.3 [ Danio rerio (zebrafish) ]

Gene ID: 573653, updated on 11-Apr-2024

Summary

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Official Symbol
hbbe1.3provided by ZNC
Official Full Name
hemoglobin, beta embryonic 1.3provided by ZNC
Primary source
ZFIN:ZDB-GENE-131120-128
See related
Ensembl:ENSDARG00000087390 AllianceGenome:ZFIN:ZDB-GENE-131120-128
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
be1c; hbbe1c; si:ch211-5k11.12
Summary
Predicted to enable several functions, including heme binding activity; oxygen binding activity; and oxygen carrier activity. Predicted to act upstream of or within oxygen transport. Predicted to be part of hemoglobin complex. Human ortholog(s) of this gene implicated in sickle cell anemia. Orthologous to human HBE1 (hemoglobin subunit epsilon 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 3
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (55131273..55132282)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (54876672..54877680)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene hemoglobin beta embryonic-1.2 Neighboring gene hemoglobin, alpha embryonic 1.3 Neighboring gene hemoglobin, alpha embryonic 1.3 Neighboring gene hemoglobin alpha embryonic-3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Evolution of the Genome 3D Organization: Comparison of Fused and Segregated Globin Gene Clusters. Kovina AP, et al. Mol Biol Evol, 2017 Jun 1. PMID 28333290
  2. Characterization of Developmental Neurobehavioral Toxicity in a Zebrafish MPTP-Induced Model: A Novel Mechanism Involving Anemia. Dong H, et al. ACS Chem Neurosci, 2022 Jul 6. PMID 35758696
  3. 6:2 fluorotelomer carboxylic acid (6:2 FTCA) exposure induces developmental toxicity and inhibits the formation of erythrocytes during zebrafish embryogenesis. Shi G, et al. Aquat Toxicol, 2017 Sep. PMID 28688371
  4. Transcriptional responses and mechanisms of copper nanoparticle toxicology on zebrafish embryos. Zhang Y, et al. J Hazard Mater, 2018 Feb 15. PMID 30216965
  5. Abnormal development of zebrafish after knockout and knockdown of ribosomal protein L10a. Palasin K, et al. Sci Rep, 2019 Dec 2. PMID 31792295, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxygen binding IEA
Inferred from Electronic Annotation
more info
  
enables oxygen carrier activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within oxygen transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of hemoglobin complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
hemoglobin, beta embryonic 1.3
Names
embryonic 1 beta-globin family member

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001365263.1 → NP_001352192.1  hemoglobin, beta embryonic 1.3

    Status: VALIDATED

    Source sequence(s)
    AL935210
    UniProtKB/TrEMBL
    A5PL87, O93548
    Conserved Domains (1) summary
    cd08925
    Location:8 → 146
    Hb-beta_like; Hemoglobin beta, gamma, delta, epsilon, and related Hb subunits

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    55131273..55132282
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005164334.4 → XP_005164391.1  hemoglobin, beta embryonic 1.3 isoform X1

    UniProtKB/TrEMBL
    O93548
    Related
    ENSDARP00000097665.1, ENSDART00000111585.3
    Conserved Domains (1) summary
    cd08925
    Location:8 → 146
    Hb-beta_like; Hemoglobin beta, gamma, delta, epsilon, and related Hb subunits
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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