cst14a.1 cystatin 14a, tandem duplicate 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cst14a.1provided by ZNC
Official Full Name: cystatin 14a, tandem duplicate 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-141031-1
See related: Ensembl:ENSDARG00000028164 AllianceGenome:ZFIN:ZDB-GENE-141031-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:ch211-161h7.6
Summary: Predicted to enable cysteine-type endopeptidase inhibitor activity. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Unverricht-Lundborg syndrome; peeling skin syndrome; and progressive myoclonus epilepsy 1A. Orthologous to several human genes including CSTB (cystatin B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 24

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (20916745..20918412)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (20772326..20773993)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cystatin 14a, tandem duplicate 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001316319.1 → NP_001303248.1 cystatin 14a, tandem duplicate 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shorter transcript and encodes the supported protein.

Source sequence(s)

CR450812

UniProtKB/TrEMBL

A0A8M1P839, E7EYW5

Related

ENSDARP00000043192.5, ENSDART00000043193.7

Conserved Domains (1) summary

pfam00031
Location:6 → 77

Cystatin; Cystatin domain

RNA

NR_133011.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' structure compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

CR450812