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Psors1c2 psoriasis susceptibility 1 candidate 2 (human) [ Mus musculus (house mouse) ]

Gene ID: 57390, updated on 5-Mar-2024

Summary

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Official Symbol
Psors1c2provided by MGI
Official Full Name
psoriasis susceptibility 1 candidate 2 (human)provided by MGI
Primary source
MGI:MGI:1930025
See related
Ensembl:ENSMUSG00000024409 AllianceGenome:MGI:1930025
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pcg; SPR1
Summary
Predicted to be located in extracellular region. Orthologous to human PSORS1C2 (psoriasis susceptibility 1 candidate 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in stomach adult (RPKM 7.3), thymus adult (RPKM 2.9) and 4 other tissues See more
Orthologs
human all
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Genomic context

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See Psors1c2 in Genome Data Viewer
Location:
17 B1; 17 18.7 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35842462..35845544)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35533201..35534647)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr17:35653747-35654048 Neighboring gene transcription factor 19 Neighboring gene coiled-coil alpha-helical rod protein 1 Neighboring gene STARR-seq mESC enhancer starr_42461 Neighboring gene corneodesmosin Neighboring gene translation machinery-associated protein 7-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Small proline-rich protein 1A is a gp130 pathway- and stress-inducible cardioprotective protein. Pradervand S, et al. EMBO J, 2004 Nov 10. PMID 15510217, Free PMC Article
  2. Polymorphisms in the SEEK1 and SPR1 genes on 6p21.3 associate with psoriasis in the Swedish population. Holm SJ, et al. Exp Dermatol, 2003 Aug. PMID 12930300
  3. Identification of candidate lung cancer susceptibility genes in mouse using oligonucleotide arrays. Lemon WJ, et al. J Med Genet, 2002 Sep. PMID 12205107, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. spr1 is a gp130 pathway- and stress-inducible cardioprotective protein.
    Title: Small proline-rich protein 1A is a gp130 pathway- and stress-inducible cardioprotective protein.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
psoriasis susceptibility 1 candidate gene 2 protein homolog
Names
MHC psoriasis candidate

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020576.2 → NP_065601.2  psoriasis susceptibility 1 candidate gene 2 protein homolog precursor

    See identical proteins and their annotated locations for NP_065601.2

    Status: VALIDATED

    Source sequence(s)
    AF484421, AK137759
    Consensus CDS
    CCDS50091.1
    UniProtKB/Swiss-Prot
    Q80ZC9
    UniProtKB/TrEMBL
    Q3UUY0
    Related
    ENSMUSP00000025273.9, ENSMUST00000025273.9
    Conserved Domains (1) summary
    pfam15356
    Location:23 → 135
    SPR1; Psoriasis susceptibility locus 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    35842462..35845544
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160707.1 → XP_036016600.1  psoriasis susceptibility 1 candidate gene 2 protein homolog isoform X1

    UniProtKB/Swiss-Prot
    Q80ZC9
    UniProtKB/TrEMBL
    Q3UUY0
    Conserved Domains (1) summary
    pfam15356
    Location:23 → 135
    SPR1; Psoriasis susceptibility locus 2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80ZC9.1 GenPept UniProtKB/Swiss-Prot:Q80ZC9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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