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Not1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 5740252, updated on 10-May-2024

Summary

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Official Symbol
Not1provided by FlyBase
Primary source
FLYBASE:FBgn0085436
Locus tag
Dmel_CG34407
See related
AllianceGenome:FB:FBgn0085436
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:Liang-1.29; anon-WO0118547.221; CG1874; CG1884; CG34407; clone 1.29; Dmel\CG34407; NOT; not1; NOT1
Old locus tag
CG1874; CG1884; Dmel_CG1874; Dmel_CG1884
Summary
Involved in nuclear-transcribed mRNA poly(A) tail shortening and ovarian follicle cell development. Located in cytosol. Part of CCR4-NOT complex. Is expressed in several structures, including embryonic brain; embryonic/larval nervous system; extended germ band embryo; gastrula embryo; and gonad. Human ortholog(s) of this gene implicated in holoprosencephaly. Orthologous to human CNOT1 (CCR4-NOT transcription complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Not1 in Genome Data Viewer
Location:
45F1-45F4; 2-61 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9566146..9579007, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5453651..5466512, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45281 Neighboring gene Odorant receptor 45b Neighboring gene Alkaline phosphatase 6 Neighboring gene long non-coding RNA:CR46257 Neighboring gene 5' nucleotidase C Neighboring gene SET and MYND domain containing, class 4, member 1 Neighboring gene Uroporphyrinogen decarboxylase Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Rapid Gene Evolution in an Ancient Post-transcriptional and Translational Regulatory System Compensates for Meiotic X Chromosomal Inactivation. Xia S, et al. Mol Biol Evol, 2022 Jan 7. PMID 34626117, Free PMC Article
  2. Silencing of CCR4-NOT complex subunits affects heart structure and function. Elmén L, et al. Dis Model Mech, 2020 Jul 20. PMID 32471864, Free PMC Article
  3. PERIOD-controlled deadenylation of the timeless transcript in the Drosophila circadian clock. Grima B, et al. Proc Natl Acad Sci U S A, 2019 Mar 19. PMID 30833404, Free PMC Article
  4. Fragile X mental retardation 1 gene enhances the translation of large autism-related proteins. Greenblatt EJ, et al. Science, 2018 Aug 17. PMID 30115809, Free PMC Article
  5. The Drosophila RNA Helicase Belle (DDX3) Non-Autonomously Suppresses Germline Tumorigenesis Via Regulation of a Specific mRNA Set. Kotov AA, et al. Cells, 2020 Feb 26. PMID 32111103, Free PMC Article

See all (107) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in follicle cell of egg chamber development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of translation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear-transcribed mRNA poly(A) tail shortening IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of CCR4-NOT complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of CCR4-NOT complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of CCR4-NOT core complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CCR4-NOT core complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Not1
Names
CG34407-PC
CG34407-PD
CG34407-PE
CG34407-PF
CG34407-PG
CG34407-PH
Not1-PC
Not1-PD
Not1-PE
Not1-PF
Not1-PG
Not1-PH

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    9566146..9579007 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165678.4 → NP_724798.3  Not1, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724798.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DY81
    Conserved Domains (5) summary
    pfam04054
    Location:2123 → 2472
    Not1; CCR4-Not complex component, Not1
    pfam12842
    Location:1500 → 1643
    DUF3819; Domain of unknown function (DUF3819)
    pfam16415
    Location:1149 → 1367
    CNOT1_CAF1_bind; CCR4-NOT transcription complex subunit 1 CAF1-binding domain
    pfam16417
    Location:900 → 1073
    CNOT1_TTP_bind; CCR4-NOT transcription complex subunit 1 TTP binding domain
    pfam16418
    Location:576 → 731
    CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat

  2. NM_001103773.3 → NP_001097243.1  Not1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097243.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DY80
    Conserved Domains (5) summary
    pfam04054
    Location:2121 → 2470
    Not1; CCR4-Not complex component, Not1
    pfam12842
    Location:1500 → 1643
    DUF3819; Domain of unknown function (DUF3819)
    pfam16415
    Location:1149 → 1367
    CNOT1_CAF1_bind; CCR4-NOT transcription complex subunit 1 CAF1-binding domain
    pfam16417
    Location:900 → 1073
    CNOT1_TTP_bind; CCR4-NOT transcription complex subunit 1 TTP binding domain
    pfam16418
    Location:576 → 731
    CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat

  3. NM_001103772.3 → NP_001097242.1  Not1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097242.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DY81
    Conserved Domains (5) summary
    pfam04054
    Location:2123 → 2472
    Not1; CCR4-Not complex component, Not1
    pfam12842
    Location:1500 → 1643
    DUF3819; Domain of unknown function (DUF3819)
    pfam16415
    Location:1149 → 1367
    CNOT1_CAF1_bind; CCR4-NOT transcription complex subunit 1 CAF1-binding domain
    pfam16417
    Location:900 → 1073
    CNOT1_TTP_bind; CCR4-NOT transcription complex subunit 1 TTP binding domain
    pfam16418
    Location:576 → 731
    CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat

  4. NM_001103774.3 → NP_001097244.1  Not1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097244.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DY82
    Conserved Domains (5) summary
    pfam04054
    Location:1838 → 2187
    Not1; CCR4-Not complex component, Not1
    pfam12842
    Location:1215 → 1358
    DUF3819; Domain of unknown function (DUF3819)
    pfam16415
    Location:864 → 1082
    CNOT1_CAF1_bind; CCR4-NOT transcription complex subunit 1 CAF1-binding domain
    pfam16417
    Location:615 → 788
    CNOT1_TTP_bind; CCR4-NOT transcription complex subunit 1 TTP binding domain
    pfam16418
    Location:291 → 446
    CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat

  5. NM_001299323.1 → NP_001286252.1  Not1, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286252.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LEZ3
    Conserved Domains (5) summary
    pfam04054
    Location:2129 → 2478
    Not1; CCR4-Not complex component, Not1
    pfam12842
    Location:1506 → 1649
    DUF3819; Domain of unknown function (DUF3819)
    pfam16415
    Location:1155 → 1373
    CNOT1_CAF1_bind; CCR4-NOT transcription complex subunit 1 CAF1-binding domain
    pfam16417
    Location:906 → 1079
    CNOT1_TTP_bind; CCR4-NOT transcription complex subunit 1 TTP binding domain
    pfam16418
    Location:582 → 737
    CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat

  6. NM_001169628.2 → NP_001163099.1  Not1, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163099.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E2QCN4
    Conserved Domains (5) summary
    pfam04054
    Location:2123 → 2472
    Not1; CCR4-Not complex component, Not1
    pfam12842
    Location:1500 → 1643
    DUF3819; Domain of unknown function (DUF3819)
    pfam16415
    Location:1149 → 1367
    CNOT1_CAF1_bind; CCR4-NOT transcription complex subunit 1 CAF1-binding domain
    pfam16417
    Location:900 → 1073
    CNOT1_TTP_bind; CCR4-NOT transcription complex subunit 1 TTP binding domain
    pfam16418
    Location:576 → 731
    CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LEZ3 A0A0B4LEZ3
A8DY80 A8DY80
A8DY81 A8DY81
A8DY82 A8DY82
E2QCN4 E2QCN4
Q8IH39 Q8IH39
Q95TG6 Q95TG6

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