COX7AL2 Cytochrome c oxidase subunit 7A-like 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: COX7AL2provided by FlyBase
Official Full Name: Cytochrome c oxidase subunit 7A-like 2provided by FlyBase
Primary source: FLYBASE:FBgn0085201
Locus tag: Dmel_CG34172
See related: AllianceGenome:FB:FBgn0085201
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG34172; COX7A2; Dmel\CG34172; Q6IHY5
Summary: Predicted to enable cytochrome-c oxidase activity. Predicted to be involved in mitochondrial respirasome assembly and regulation of oxidative phosphorylation. Predicted to be active in mitochondrial respirasome. Is expressed in adult head. Orthologous to human COX7A1 (cytochrome c oxidase subunit 7A1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 22D1-22D1; 2-5 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (2192525..2197912, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (2192525..2197912, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Process	Evidence Code	Pubs
involved_in mitochondrial electron transport, cytochrome c to oxygen	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial respirasome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of oxidative phosphorylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in mitochondrial respirasome	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial respirasome	IEA Inferred from Electronic Annotation more info
part_of mitochondrial respiratory chain complex IV	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome c oxidase subunit 7A-like 2

Names: CG34172-PA; CG34172-PB; CG34172-PC; CG34172-PD; COX7AL2-PA; COX7AL2-PB; COX7AL2-PC; COX7AL2-PD; cytochrome c oxidase subunit 7A1, mitochondrial

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

2192525..2197912 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001272983.1 → NP_001259912.1 cytochrome c oxidase subunit 7A-like 2, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259912.1

Status: REVIEWED

UniProtKB/TrEMBL

Q6IHY5

Conserved Domains (1) summary

cd00928
Location:3 → 57

Cyt_c_Oxidase_VIIa; Cytochrome c oxidase subunit VIIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
NM_001258917.1 → NP_001245846.1 cytochrome c oxidase subunit 7A-like 2, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245846.1

Status: REVIEWED

UniProtKB/TrEMBL

Q6IHY5

Conserved Domains (1) summary

cd00928
Location:3 → 57

Cyt_c_Oxidase_VIIa; Cytochrome c oxidase subunit VIIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
NM_001103584.1 → NP_001097054.1 cytochrome c oxidase subunit 7A-like 2, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097054.1

Status: REVIEWED

UniProtKB/TrEMBL

Q6IHY5

Conserved Domains (1) summary

cd00928
Location:3 → 57

Cyt_c_Oxidase_VIIa; Cytochrome c oxidase subunit VIIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
NM_001272984.1 → NP_001259913.1 cytochrome c oxidase subunit 7A-like 2, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259913.1

Status: REVIEWED

UniProtKB/TrEMBL

Q6IHY5

Conserved Domains (1) summary

cd00928
Location:3 → 57

Cyt_c_Oxidase_VIIa; Cytochrome c oxidase subunit VIIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...