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VLDLR very low density lipoprotein receptor [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 574284, updated on 5-Mar-2024

Summary

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Official Symbol
VLDLRprovided by VGNC
Official Full Name
very low density lipoprotein receptorprovided by VGNC
Primary source
VGNC:VGNC:78774
See related
Ensembl:ENSMMUG00000015093
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 15
Exon count:
19
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 15 NC_041768.1 (81221283..81255845, complement)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 15 NC_027907.1 (81867938..81904681, complement)

Chromosome 15 - NC_041768.1Genomic Context describing neighboring genes Neighboring gene pumilio RNA binding family member 3 Neighboring gene uncharacterized LOC114672804 Neighboring gene potassium voltage-gated channel modifier subfamily V member 2 Neighboring gene uncharacterized LOC106993776 Neighboring gene bcl-2-like protein 12 pseudogene Neighboring gene uncharacterized LOC114672805 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Low-density lipoprotein receptor gene therapy using helper-dependent adenovirus produces long-term protection against atherosclerosis in a mouse model of familial hypercholesterolemia. Nomura S, et al. Gene Ther, 2004 Oct. PMID 15269711
  2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables apolipoprotein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
very low-density lipoprotein receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001032907.1 → NP_001028079.1  very low-density lipoprotein receptor precursor

    See identical proteins and their annotated locations for NP_001028079.1

    Status: VALIDATED

    Source sequence(s)
    AY466855
    UniProtKB/TrEMBL
    H9ERH1, Q6S4M1
    Related
    ENSMMUP00000019793.3, ENSMMUT00000021167.4
    Conserved Domains (8) summary
    smart00192
    Location:71 → 103
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:505 → 547
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:396 → 426
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:33 → 67
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam01456
    Location:751 → 813
    Mucin; Mucin-like glycoprotein
    pfam00057
    Location:237 → 273
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:568 → 608
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:360 → 394
    FXa_inhibition; Coagulation Factor Xa inhibitory site

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041768.1 Reference Mmul_10 Primary Assembly

    Range
    81221283..81255845 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_028834203.1 → XP_028690036.1  very low-density lipoprotein receptor isoform X3

    UniProtKB/TrEMBL
    F6WUJ6
    Related
    ENSMMUP00000019791.4, ENSMMUT00000021165.4
    Conserved Domains (7) summary
    smart00192
    Location:145 → 177
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:538 → 580
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:429 → 459
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:107 → 141
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00057
    Location:270 → 306
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:601 → 641
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:393 → 427
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  2. XM_015117783.2 → XP_014973269.1  very low-density lipoprotein receptor isoform X2

    UniProtKB/TrEMBL
    F6WUJ6
    Conserved Domains (8) summary
    smart00192
    Location:145 → 177
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:538 → 580
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:429 → 459
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:107 → 141
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam01456
    Location:784 → 846
    Mucin; Mucin-like glycoprotein
    pfam00057
    Location:270 → 306
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:601 → 641
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:393 → 427
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  3. XM_015117782.2 → XP_014973268.1  very low-density lipoprotein receptor isoform X1

    UniProtKB/TrEMBL
    F6WNM1, H9ERP6
    Related
    ENSMMUP00000019794.4, ENSMMUT00000021168.4
    Conserved Domains (7) summary
    smart00192
    Location:145 → 177
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:579 → 621
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:470 → 500
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:107 → 141
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00057
    Location:311 → 347
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:642 → 682
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:434 → 468
    FXa_inhibition; Coagulation Factor Xa inhibitory site
Nucleotide Protein
Heading Accession and Version

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