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ZNF624 zinc finger protein 624 [ Homo sapiens (human) ]

Gene ID: 57547, updated on 3-Apr-2024

Summary

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Official Symbol
ZNF624provided by HGNC
Official Full Name
zinc finger protein 624provided by HGNC
Primary source
HGNC:HGNC:29254
See related
Ensembl:ENSG00000197566 AllianceGenome:HGNC:29254
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 2.9), ovary (RPKM 1.2) and 24 other tissues See more
Orthologs
all
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Genomic context

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Location:
17p11.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (16614247..16653850, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (16516506..16556066, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (16524048..16557164, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903941 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11768 Neighboring gene uncharacterized LOC105371554 Neighboring gene zinc finger protein 287 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:16471581-16472082 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:16472083-16472582 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11769 Neighboring gene SRSF6 pseudogene 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:16556408-16556918 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8228 Neighboring gene uncharacterized LOC124903934 Neighboring gene coiled-coil domain containing 144A Neighboring gene NIMA-related kinase 4 pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 2000 Feb 28. PMID 10718198
  2. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. Butland SL, et al. Hum Mol Genet, 2014 Aug 1. PMID 24705354, Free PMC Article
  3. A Large-scale genetic association study of esophageal adenocarcinoma risk. Liu CY, et al. Carcinogenesis, 2010 Jul. PMID 20453000, Free PMC Article
  4. Widespread macromolecular interaction perturbations in human genetic disorders. Sahni N, et al. Cell, 2015 Apr 23. PMID 25910212, Free PMC Article
  5. Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling. Kouranti I, et al. Int J Mol Sci, 2022 May 5. PMID 35563538, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association. (HuGE Navigator)
    Title: A Large-scale genetic association study of esophageal adenocarcinoma risk.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1349, MGC119602, MGC119603, MGC119605

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 624

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020787.4 → NP_065838.2  zinc finger protein 624

    See identical proteins and their annotated locations for NP_065838.2

    Status: VALIDATED

    Source sequence(s)
    BC103943, BF435259, DA808501
    Consensus CDS
    CCDS11180.1
    UniProtKB/Swiss-Prot
    Q3SY62, Q3SY63, Q6ZN27, Q9P2J8
    Related
    ENSP00000310472.7, ENST00000311331.12
    Conserved Domains (4) summary
    smart00349
    Location:54 → 114
    KRAB; krueppel associated box
    COG5048
    Location:414 → 826
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:502 → 522
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:826 → 847
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    16614247..16653850 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047436461.1 → XP_047292417.1  zinc finger protein 624 isoform X3

    Related
    ENSP00000463295.1, ENST00000583766.5

  2. XM_011523970.3 → XP_011522272.1  zinc finger protein 624 isoform X2

    Conserved Domains (6) summary
    smart00349
    Location:52 → 112
    KRAB; krueppel associated box
    COG5048
    Location:412 → 824
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:500 → 520
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:386 → 408
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:52 → 91
    KRAB; KRAB box
    pfam13465
    Location:344 → 369
    zf-H2C2_2; Zinc-finger double domain

  3. XM_047436460.1 → XP_047292416.1  zinc finger protein 624 isoform X2

  4. XM_006721562.5 → XP_006721625.1  zinc finger protein 624 isoform X1

    See identical proteins and their annotated locations for XP_006721625.1

    UniProtKB/Swiss-Prot
    Q3SY62, Q3SY63, Q6ZN27, Q9P2J8
    Conserved Domains (4) summary
    smart00349
    Location:54 → 114
    KRAB; krueppel associated box
    COG5048
    Location:414 → 826
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:502 → 522
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:826 → 847
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    16516506..16556066 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054316750.1 → XP_054172725.1  zinc finger protein 624 isoform X3

  2. XM_054316748.1 → XP_054172723.1  zinc finger protein 624 isoform X2

  3. XM_054316747.1 → XP_054172722.1  zinc finger protein 624 isoform X1

  4. XM_054316749.1 → XP_054172724.1  zinc finger protein 624 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9P2J8.3 GenPept UniProtKB/Swiss-Prot:Q9P2J8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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