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FAM135A family with sequence similarity 135 member A [ Homo sapiens (human) ]

Gene ID: 57579, updated on 5-Mar-2024

Summary

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Official Symbol
FAM135Aprovided by HGNC
Official Full Name
family with sequence similarity 135 member Aprovided by HGNC
Primary source
HGNC:HGNC:21084
See related
Ensembl:ENSG00000082269 AllianceGenome:HGNC:21084
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KIAA1411
Summary
Predicted to be involved in cellular lipid metabolic process. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in esophagus (RPKM 17.6), prostate (RPKM 12.9) and 22 other tissues See more
Orthologs
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Genomic context

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Location:
6q13
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (70413508..70561174)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (71594068..71741718)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (71123211..71270877)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377848 Neighboring gene Sharpr-MPRA regulatory region 4194 Neighboring gene uncharacterized LOC105377847 Neighboring gene long intergenic non-protein coding RNA 1610 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17317 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17318 Neighboring gene FAM135A antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24731 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24732 Neighboring gene RNA, U7 small nuclear 48 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17319 Neighboring gene succinate dehydrogenase complex assembly factor 4 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:71310594-71311158 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:71318535-71319052 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:71319053-71319569 Neighboring gene spermine synthase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Convergent animal and human evidence suggests a role of PPM1A gene in response to antidepressants. Malki K, et al. Biol Psychiatry, 2011 Feb 15. PMID 20970119
  2. Genome-wide searching of rare genetic variants in WTCCC data. Feng T, et al. Hum Genet, 2010 Sep. PMID 20549515, Free PMC Article
  3. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 2000 Feb 28. PMID 10718198
  4. Spatial proteomics reveal that the protein phosphatase PTP1B interacts with and may modify tyrosine phosphorylation of the rhomboid protease RHBDL4. Ikeda KN, et al. J Biol Chem, 2019 Jul 26. PMID 31177093, Free PMC Article
  5. RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy. Radaszkiewicz T, et al. Elife, 2021 Oct 27. PMID 34702444, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LncRNA MIR17HG Suppresses Breast Cancer Proliferation and Migration as ceRNA to Target FAM135A by Sponging miR-454-3p.
    Title: LncRNA MIR17HG Suppresses Breast Cancer Proliferation and Migration as ceRNA to Target FAM135A by Sponging miR-454-3p.
  2. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Convergent animal and human evidence suggests a role of PPM1A gene in response to antidepressants.
  3. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: Genome-wide searching of rare genetic variants in WTCCC data.
  4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ13577, KIAA1411, DKFZp781H2319

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cellular lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein FAM135A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_054903.1 RefSeqGene

    Range
    5105..152771
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001105531.3 → NP_001099001.1  protein FAM135A isoform a

    Status: VALIDATED

    Source sequence(s)
    AB037832, AJ420590, BC131782, DB462733
    Consensus CDS
    CCDS47448.1
    UniProtKB/Swiss-Prot
    Q9P2D6
    Related
    ENSP00000354913.3, ENST00000361499.7
    Conserved Domains (2) summary
    pfam05057
    Location:1048 → 1243
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:111 → 171
    DUF3657; Protein of unknown function (DUF3657)

  2. NM_001162529.3 → NP_001156001.1  protein FAM135A isoform c

    See identical proteins and their annotated locations for NP_001156001.1

    Status: VALIDATED

    Source sequence(s)
    AL078591, AL365226
    Consensus CDS
    CCDS55028.1
    UniProtKB/Swiss-Prot
    A2RRQ5, Q3C0H3, Q5JXK0, Q5JXK1, Q68DW0, Q6P081, Q9H0F2, Q9NU48, Q9NUQ5, Q9NXL5, Q9P2D6
    Related
    ENSP00000410768.2, ENST00000418814.7
    Conserved Domains (2) summary
    pfam05057
    Location:1244 → 1439
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:111 → 171
    DUF3657; Protein FAM135

  3. NM_001330995.3 → NP_001317924.1  protein FAM135A isoform d

    Status: VALIDATED

    Source sequence(s)
    AJ420590, AL078591, AL365226
    Consensus CDS
    CCDS83104.1
    UniProtKB/TrEMBL
    D6RCC7

  4. NM_001330996.3 → NP_001317925.1  protein FAM135A isoform e

    Status: VALIDATED

    Source sequence(s)
    AJ420590, AL078591, AL365226
    Conserved Domains (2) summary
    pfam05057
    Location:1270 → 1465
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:111 → 171
    DUF3657; Protein FAM135

  5. NM_001330997.3 → NP_001317926.1  protein FAM135A isoform a

    Status: VALIDATED

    Source sequence(s)
    AJ420590, AL078591, AL365226
    Consensus CDS
    CCDS47448.1
    UniProtKB/Swiss-Prot
    Q9P2D6
    Conserved Domains (2) summary
    pfam05057
    Location:1048 → 1243
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:111 → 171
    DUF3657; Protein of unknown function (DUF3657)

  6. NM_001330998.3 → NP_001317927.1  protein FAM135A isoform f

    Status: VALIDATED

    Source sequence(s)
    AJ420590, AL078591, AL365226
    Conserved Domains (2) summary
    pfam05057
    Location:1074 → 1269
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:111 → 171
    DUF3657; Protein of unknown function (DUF3657)

  7. NM_001330999.3 → NP_001317928.1  protein FAM135A isoform e

    Status: VALIDATED

    Source sequence(s)
    AJ420590, AL078591, AL365226
    Conserved Domains (2) summary
    pfam05057
    Location:1270 → 1465
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:111 → 171
    DUF3657; Protein FAM135

  8. NM_001331000.3 → NP_001317929.1  protein FAM135A isoform g

    Status: VALIDATED

    Source sequence(s)
    AJ420590, AL078591, AL365226

  9. NM_001331001.3 → NP_001317930.1  protein FAM135A isoform a

    Status: VALIDATED

    Source sequence(s)
    AJ420590, AL078591, AL365226
    Consensus CDS
    CCDS47448.1
    UniProtKB/Swiss-Prot
    Q9P2D6
    Conserved Domains (2) summary
    pfam05057
    Location:1048 → 1243
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:111 → 171
    DUF3657; Protein of unknown function (DUF3657)

  10. NM_001331002.3 → NP_001317931.1  protein FAM135A isoform a

    Status: VALIDATED

    Source sequence(s)
    AJ420590, AL078591, AL365226
    Consensus CDS
    CCDS47448.1
    UniProtKB/Swiss-Prot
    Q9P2D6
    Conserved Domains (2) summary
    pfam05057
    Location:1048 → 1243
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:111 → 171
    DUF3657; Protein of unknown function (DUF3657)

  11. NM_001331003.3 → NP_001317932.1  protein FAM135A isoform f

    Status: VALIDATED

    Source sequence(s)
    AJ420590, AL078591, AL365226
    Conserved Domains (2) summary
    pfam05057
    Location:1074 → 1269
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:111 → 171
    DUF3657; Protein of unknown function (DUF3657)

  12. NM_001331004.3 → NP_001317933.1  protein FAM135A isoform h

    Status: VALIDATED

    Source sequence(s)
    AJ420590, AL078591, AL365226

  13. NM_001331005.3 → NP_001317934.1  protein FAM135A isoform i

    Status: VALIDATED

    Source sequence(s)
    AJ420590, AL078591, AL365226

  14. NM_001331006.3 → NP_001317935.1  protein FAM135A isoform j

    Status: VALIDATED

    Source sequence(s)
    AJ420590, AL078591, AL365226
    Conserved Domains (2) summary
    pfam05057
    Location:850 → 1045
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:111 → 171
    DUF3657; Protein of unknown function (DUF3657)

  15. NM_001351599.2 → NP_001338528.1  protein FAM135A isoform e

    Status: VALIDATED

    Source sequence(s)
    AJ420590, AL078591, AL365226
    Conserved Domains (2) summary
    pfam05057
    Location:1270 → 1465
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:111 → 171
    DUF3657; Protein FAM135

  16. NM_001351600.2 → NP_001338529.1  protein FAM135A isoform c

    Status: VALIDATED

    Source sequence(s)
    AJ420590, AL078591, AL365226
    Consensus CDS
    CCDS55028.1
    UniProtKB/Swiss-Prot
    A2RRQ5, Q3C0H3, Q5JXK0, Q5JXK1, Q68DW0, Q6P081, Q9H0F2, Q9NU48, Q9NUQ5, Q9NXL5, Q9P2D6
    Related
    ENSP00000359510.4, ENST00000370479.7
    Conserved Domains (2) summary
    pfam05057
    Location:1244 → 1439
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:111 → 171
    DUF3657; Protein FAM135

  17. NM_001351602.2 → NP_001338531.1  protein FAM135A isoform c

    Status: VALIDATED

    Source sequence(s)
    AJ420590, AL078591, AL365226
    Consensus CDS
    CCDS55028.1
    UniProtKB/Swiss-Prot
    A2RRQ5, Q3C0H3, Q5JXK0, Q5JXK1, Q68DW0, Q6P081, Q9H0F2, Q9NU48, Q9NUQ5, Q9NXL5, Q9P2D6
    Conserved Domains (2) summary
    pfam05057
    Location:1244 → 1439
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:111 → 171
    DUF3657; Protein FAM135

  18. NM_001351607.2 → NP_001338536.1  protein FAM135A isoform c

    Status: VALIDATED

    Source sequence(s)
    AJ420590, AL078591, AL365226
    Consensus CDS
    CCDS55028.1
    UniProtKB/Swiss-Prot
    A2RRQ5, Q3C0H3, Q5JXK0, Q5JXK1, Q68DW0, Q6P081, Q9H0F2, Q9NU48, Q9NUQ5, Q9NXL5, Q9P2D6
    Conserved Domains (2) summary
    pfam05057
    Location:1244 → 1439
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:111 → 171
    DUF3657; Protein FAM135

  19. NM_001351608.2 → NP_001338537.1  protein FAM135A isoform k

    Status: VALIDATED

    Source sequence(s)
    AJ420590, AL078591, AL365226
    Conserved Domains (2) summary
    pfam05057
    Location:962 → 1157
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:25 → 85
    DUF3657; Protein FAM135

  20. NM_001351609.2 → NP_001338538.1  protein FAM135A isoform l

    Status: VALIDATED

    Source sequence(s)
    AJ420590, AL078591, AL365226
    Conserved Domains (2) summary
    pfam05057
    Location:764 → 959
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:25 → 85
    DUF3657; Protein FAM135

  21. NM_020819.5 → NP_065870.3  protein FAM135A isoform b

    Status: VALIDATED

    Source sequence(s)
    AB037832, AJ420590, BC131782, CR749254, DB462733
    Consensus CDS
    CCDS34481.1
    UniProtKB/Swiss-Prot
    Q9P2D6
    Related
    ENSP00000409201.2, ENST00000457062.6
    Conserved Domains (2) summary
    pfam05057
    Location:1031 → 1226
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:68 → 128
    DUF3657; Protein of unknown function (DUF3657)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    70413508..70561174
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047419158.1 → XP_047275114.1  protein FAM135A isoform X1

  2. XM_047419165.1 → XP_047275121.1  protein FAM135A isoform X4

  3. XM_047419169.1 → XP_047275125.1  protein FAM135A isoform X8

  4. XM_047419175.1 → XP_047275131.1  protein FAM135A isoform X9

    UniProtKB/TrEMBL
    D6RCC7

  5. XM_005248749.2 → XP_005248806.1  protein FAM135A isoform X6

    Conserved Domains (2) summary
    pfam05057
    Location:1046 → 1241
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:111 → 171
    DUF3657; Protein of unknown function (DUF3657)

  6. XM_047419168.1 → XP_047275124.1  protein FAM135A isoform X7

  7. XM_011535995.4 → XP_011534297.1  protein FAM135A isoform X1

    See identical proteins and their annotated locations for XP_011534297.1

    Conserved Domains (2) summary
    pfam05057
    Location:1270 → 1465
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:111 → 171
    DUF3657; Protein FAM135

  8. XM_047419162.1 → XP_047275118.1  protein FAM135A isoform X4

  9. XM_047419171.1 → XP_047275127.1  protein FAM135A isoform X8

  10. XM_047419159.1 → XP_047275115.1  protein FAM135A isoform X2

    UniProtKB/Swiss-Prot
    A2RRQ5, Q3C0H3, Q5JXK0, Q5JXK1, Q68DW0, Q6P081, Q9H0F2, Q9NU48, Q9NUQ5, Q9NXL5, Q9P2D6

  11. XM_047419167.1 → XP_047275123.1  protein FAM135A isoform X5

  12. XM_047419180.1 → XP_047275136.1  protein FAM135A isoform X9

    UniProtKB/TrEMBL
    D6RCC7

  13. XM_011535994.3 → XP_011534296.1  protein FAM135A isoform X1

    See identical proteins and their annotated locations for XP_011534296.1

    Conserved Domains (2) summary
    pfam05057
    Location:1270 → 1465
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:111 → 171
    DUF3657; Protein FAM135

  14. XM_047419173.1 → XP_047275129.1  protein FAM135A isoform X8

  15. XM_047419166.1 → XP_047275122.1  protein FAM135A isoform X5

  16. XM_047419176.1 → XP_047275132.1  protein FAM135A isoform X9

    UniProtKB/TrEMBL
    D6RCC7

  17. XM_011535996.3 → XP_011534298.1  protein FAM135A isoform X1

    See identical proteins and their annotated locations for XP_011534298.1

    Conserved Domains (2) summary
    pfam05057
    Location:1270 → 1465
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:111 → 171
    DUF3657; Protein FAM135

  18. XM_047419163.1 → XP_047275119.1  protein FAM135A isoform X4

  19. XM_047419172.1 → XP_047275128.1  protein FAM135A isoform X8

  20. XM_047419160.1 → XP_047275116.1  protein FAM135A isoform X2

    UniProtKB/Swiss-Prot
    A2RRQ5, Q3C0H3, Q5JXK0, Q5JXK1, Q68DW0, Q6P081, Q9H0F2, Q9NU48, Q9NUQ5, Q9NXL5, Q9P2D6

  21. XM_047419179.1 → XP_047275135.1  protein FAM135A isoform X9

    UniProtKB/TrEMBL
    D6RCC7

  22. XM_047419164.1 → XP_047275120.1  protein FAM135A isoform X4

  23. XM_047419174.1 → XP_047275130.1  protein FAM135A isoform X8

  24. XM_017011127.2 → XP_016866616.1  protein FAM135A isoform X2

    UniProtKB/Swiss-Prot
    A2RRQ5, Q3C0H3, Q5JXK0, Q5JXK1, Q68DW0, Q6P081, Q9H0F2, Q9NU48, Q9NUQ5, Q9NXL5, Q9P2D6
    Related
    ENSP00000423307.1, ENST00000505868.1
    Conserved Domains (2) summary
    pfam05057
    Location:1244 → 1439
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:111 → 171
    DUF3657; Protein FAM135

  25. XM_047419178.1 → XP_047275134.1  protein FAM135A isoform X9

    UniProtKB/TrEMBL
    D6RCC7
    Related
    ENSP00000423785.1, ENST00000505769.5

  26. XM_011535997.3 → XP_011534299.1  protein FAM135A isoform X3

    Conserved Domains (2) summary
    pfam05057
    Location:1237 → 1432
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:78 → 138
    DUF3657; Protein of unknown function (DUF3657)

  27. XM_047419161.1 → XP_047275117.1  protein FAM135A isoform X4

  28. XM_047419170.1 → XP_047275126.1  protein FAM135A isoform X8

  29. XM_047419177.1 → XP_047275133.1  protein FAM135A isoform X9

    UniProtKB/TrEMBL
    D6RCC7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    71594068..71741718
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054356070.1 → XP_054212045.1  protein FAM135A isoform X1

  2. XM_054356079.1 → XP_054212054.1  protein FAM135A isoform X4

  3. XM_054356084.1 → XP_054212059.1  protein FAM135A isoform X8

  4. XM_054356090.1 → XP_054212065.1  protein FAM135A isoform X9

  5. XM_054356082.1 → XP_054212057.1  protein FAM135A isoform X6

  6. XM_054356083.1 → XP_054212058.1  protein FAM135A isoform X7

  7. XM_054356069.1 → XP_054212044.1  protein FAM135A isoform X1

  8. XM_054356076.1 → XP_054212051.1  protein FAM135A isoform X4

  9. XM_054356086.1 → XP_054212061.1  protein FAM135A isoform X8

  10. XM_054356071.1 → XP_054212046.1  protein FAM135A isoform X2

  11. XM_054356081.1 → XP_054212056.1  protein FAM135A isoform X5

  12. XM_054356095.1 → XP_054212070.1  protein FAM135A isoform X9

  13. XM_054356067.1 → XP_054212042.1  protein FAM135A isoform X1

  14. XM_054356088.1 → XP_054212063.1  protein FAM135A isoform X8

  15. XM_054356080.1 → XP_054212055.1  protein FAM135A isoform X5

  16. XM_054356091.1 → XP_054212066.1  protein FAM135A isoform X9

  17. XM_054356068.1 → XP_054212043.1  protein FAM135A isoform X1

  18. XM_054356077.1 → XP_054212052.1  protein FAM135A isoform X4

  19. XM_054356087.1 → XP_054212062.1  protein FAM135A isoform X8

  20. XM_054356072.1 → XP_054212047.1  protein FAM135A isoform X2

  21. XM_054356094.1 → XP_054212069.1  protein FAM135A isoform X9

  22. XM_054356078.1 → XP_054212053.1  protein FAM135A isoform X4

  23. XM_054356089.1 → XP_054212064.1  protein FAM135A isoform X8

  24. XM_054356073.1 → XP_054212048.1  protein FAM135A isoform X2

  25. XM_054356093.1 → XP_054212068.1  protein FAM135A isoform X9

  26. XM_054356074.1 → XP_054212049.1  protein FAM135A isoform X3

  27. XM_054356075.1 → XP_054212050.1  protein FAM135A isoform X4

  28. XM_054356085.1 → XP_054212060.1  protein FAM135A isoform X8

  29. XM_054356092.1 → XP_054212067.1  protein FAM135A isoform X9

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9P2D6.2 GenPept UniProtKB/Swiss-Prot:Q9P2D6

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