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RANBP10 RAN binding protein 10 [ Homo sapiens (human) ]

Gene ID: 57610, updated on 7-Apr-2024

Summary

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Official Symbol
RANBP10provided by HGNC
Official Full Name
RAN binding protein 10provided by HGNC
Primary source
HGNC:HGNC:29285
See related
Ensembl:ENSG00000141084 MIM:614031; AllianceGenome:HGNC:29285
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
RAN is a small GTPase involved in the assembly of microtubules to form mitotic spindles. The protein encoded by this gene is a cytoplasmic guanine nucleotide exchange factor (GEF) that binds beta-tubulin and has GEF activity toward RAN. The encoded protein plays a role in the formation of noncentrosomal microtubules. In addition, this protein may be involved in the regulation of D(1) receptor signaling by protein kinase C delta and protein kinase C gamma. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
Expression
Ubiquitous expression in bone marrow (RPKM 13.1), endometrium (RPKM 6.2) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
16q22.1
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (67723070..67806560, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (73517838..73601583, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67756973..67840463, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7620 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7621 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7622 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10979 Neighboring gene chromosome 16 open reading frame 86 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67710969-67711925 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67711926-67712881 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:67717419-67718618 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10980 Neighboring gene Gfo/Idh/MocA-like oxidoreductase domain containing 2 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr16:67743233-67744011 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67744012-67744789 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10981 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7623 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7624 Neighboring gene Sharpr-MPRA regulatory region 12647 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10982 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10983 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10984 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:67839586-67840206 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:67840207-67840826 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7626 Neighboring gene translin associated factor X interacting protein 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:67851021-67851203 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67859393-67860253 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10986 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10987 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10988 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7627 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67876439-67877185 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10990 Neighboring gene centromere protein T Neighboring gene THAP domain containing 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A Ran-binding protein facilitates nuclear import of human papillomavirus type 16. Lai KY, et al. PLoS Pathog, 2021 May. PMID 33974675, Free PMC Article
  2. miR-196a Enhances Neuronal Morphology through Suppressing RANBP10 to Provide Neuroprotection in Huntington's Disease. Her LS, et al. Theranostics, 2017. PMID 28744327, Free PMC Article
  3. Cellular Transcriptional Coactivator RanBP10 and Herpes Simplex Virus 1 ICP0 Interact and Synergistically Promote Viral Gene Expression and Replication. Sato Y, et al. J Virol, 2016 Jan 6. PMID 26739050, Free PMC Article
  4. RANBP10 promotes glioblastoma progression by regulating the FBXW7/c-Myc pathway. Hou J, et al. Cell Death Dis, 2021 Oct 20. PMID 34671019, Free PMC Article
  5. A novel MET-interacting protein shares high sequence similarity with RanBPM, but fails to stimulate MET-induced Ras/Erk signaling. Wang D, et al. Biochem Biophys Res Commun, 2004 Jan 9. PMID 14684163

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RANBP10 promotes glioblastoma progression by regulating the FBXW7/c-Myc pathway.
    Title: RANBP10 promotes glioblastoma progression by regulating the FBXW7/c-Myc pathway.
  2. A Ran-binding protein facilitates nuclear import of human papillomavirus type 16.
    Title: A Ran-binding protein facilitates nuclear import of human papillomavirus type 16.
  3. Authors provide evidence that enhancement of neuronal morphology through RANBP10 is one of the neuroprotective mechanisms for miR-196a.
    Title: miR-196a Enhances Neuronal Morphology through Suppressing RANBP10 to Provide Neuroprotection in Huntington's Disease.
  4. The results showed that ICP0 interacted with cell protein RanBP10, a known transcriptional coactivator, in human herpesvirus 1-infected cells.
    Title: Cellular Transcriptional Coactivator RanBP10 and Herpes Simplex Virus 1 ICP0 Interact and Synergistically Promote Viral Gene Expression and Replication.
  5. data support the idea that RanBP9 and RanBP10 may function as signaling integrators and dictate the efficient regulation of D(1) receptor signaling by PKCdelta and PKCgamma
    Title: Identification of RanBP 9/10 as interacting partners for protein kinase C (PKC) gamma/delta and the D1 dopamine receptor: regulation of PKC-mediated receptor phosphorylation.
  6. RanBP10 might serve as a molecular link between Ran and noncentrosomal microtubules
    Title: RanBP10 is a cytoplasmic guanine nucleotide exchange factor that modulates noncentrosomal microtubules.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ31165, KIAA1464

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ran-binding protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320238.2 → NP_001307167.1  ran-binding protein 10 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate 5' exon and uses an alternate in-frame splice junction in the 3' end compared to variant 1. The resulting isoform (2) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AI275875, AK295530, AY337313
    UniProtKB/Swiss-Prot
    Q6VN20
    Conserved Domains (5) summary
    smart00667
    Location:140 → 167
    LisH; Lissencephaly type-1-like homology motif
    smart00668
    Location:174 → 230
    CTLH; C-terminal to LisH motif
    smart00757
    Location:420 → 517
    CRA; CT11-RanBPM
    pfam10607
    Location:174 → 228
    CLTH; CTLH/CRA C-terminal to LisH motif domain
    cd12909
    Location:1 → 102
    SPRY_RanBP9_10; SPRY domain in Ran binding proteins 9 and 10

  2. NM_001320239.2 → NP_001307168.1  ran-binding protein 10 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AI275875, AK298806, AY337313
    Consensus CDS
    CCDS81999.1
    UniProtKB/Swiss-Prot
    Q6VN20
    Related
    ENSP00000392808.2, ENST00000448631.6
    Conserved Domains (5) summary
    smart00667
    Location:201 → 228
    LisH; Lissencephaly type-1-like homology motif
    smart00668
    Location:235 → 291
    CTLH; C-terminal to LisH motif
    smart00757
    Location:481 → 578
    CRA; CT11-RanBPM
    pfam10607
    Location:235 → 289
    CLTH; CTLH/CRA C-terminal to LisH motif domain
    cl02614
    Location:77 → 163
    SPRY; SPRY domain

  3. NM_001320240.2 → NP_001307169.1  ran-binding protein 10 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains three alternate internal exons compared to variant 1. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AI275875, AK055727, AY337313
    UniProtKB/TrEMBL
    B3KP49
    Conserved Domains (4) summary
    smart00667
    Location:28 → 55
    LisH; Lissencephaly type-1-like homology motif
    smart00668
    Location:62 → 118
    CTLH; C-terminal to LisH motif
    smart00757
    Location:278 → 375
    CRA; CT11-RanBPM
    pfam10607
    Location:62 → 116
    CLTH; CTLH/CRA C-terminal to LisH motif domain

  4. NM_001410883.1 → NP_001397812.1  ran-binding protein 10 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC010530, AC040162
    Consensus CDS
    CCDS92180.1
    UniProtKB/TrEMBL
    R4GMX8
    Related
    ENSP00000473396.1, ENST00000602677.5

  5. NM_020850.3 → NP_065901.1  ran-binding protein 10 isoform 1

    See identical proteins and their annotated locations for NP_065901.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AI275875, AY337313
    Consensus CDS
    CCDS32469.1
    UniProtKB/Swiss-Prot
    A4FTY2, B4DID0, B4DQH9, E7EW27, Q6VN20, Q9P264
    Related
    ENSP00000316589.3, ENST00000317506.8
    Conserved Domains (5) summary
    smart00667
    Location:257 → 284
    LisH; Lissencephaly type-1-like homology motif
    smart00668
    Location:291 → 347
    CTLH; C-terminal to LisH motif
    smart00757
    Location:507 → 604
    CRA; CT11-RanBPM
    pfam10607
    Location:291 → 345
    CLTH; CTLH/CRA C-terminal to LisH motif domain
    cd12909
    Location:77 → 219
    SPRY_RanBP9_10; SPRY domain in Ran binding proteins 9 and 10

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    67723070..67806560 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434407.1 → XP_047290363.1  ran-binding protein 10 isoform X1

  2. XM_047434409.1 → XP_047290365.1  ran-binding protein 10 isoform X4

  3. XM_011523247.4 → XP_011521549.1  ran-binding protein 10 isoform X4

    See identical proteins and their annotated locations for XP_011521549.1

    Conserved Domains (4) summary
    smart00667
    Location:28 → 55
    LisH; Lissencephaly type-1-like homology motif
    smart00668
    Location:62 → 118
    CTLH; C-terminal to LisH motif
    smart00757
    Location:308 → 405
    CRA; CT11-RanBPM
    pfam10607
    Location:62 → 116
    CLTH; CTLH/CRA C-terminal to LisH motif domain

  4. XM_006721238.5 → XP_006721301.1  ran-binding protein 10 isoform X2

    Conserved Domains (3) summary
    smart00668
    Location:135 → 191
    CTLH; C-terminal to LisH motif
    smart00757
    Location:381 → 478
    CRA; CT11-RanBPM
    pfam10607
    Location:135 → 189
    CLTH; CTLH/CRA C-terminal to LisH motif domain

  5. XM_047434408.1 → XP_047290364.1  ran-binding protein 10 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    73517838..73601583 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054313560.1 → XP_054169535.1  ran-binding protein 10 isoform X1

  2. XM_054313564.1 → XP_054169539.1  ran-binding protein 10 isoform X4

  3. XM_054313563.1 → XP_054169538.1  ran-binding protein 10 isoform X4

  4. XM_054313561.1 → XP_054169536.1  ran-binding protein 10 isoform X2

  5. XM_054313562.1 → XP_054169537.1  ran-binding protein 10 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6VN20.1 GenPept UniProtKB/Swiss-Prot:Q6VN20

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