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UVSSA UV stimulated scaffold protein A [ Homo sapiens (human) ]

Gene ID: 57654, updated on 3-Apr-2024

Summary

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Official Symbol
UVSSAprovided by HGNC
Official Full Name
UV stimulated scaffold protein Aprovided by HGNC
Primary source
HGNC:HGNC:29304
See related
Ensembl:ENSG00000163945 MIM:614632; AllianceGenome:HGNC:29304
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UVSS3; KIAA1530
Summary
The protein encoded by this gene appears to be involved in ubiquitination and dephosphorylation of RNA polymerase II subunits that stall after UV irradiation. The encoded protein interacts with several members of the nucleotide excision repair complex, and is thought to be involved in the transcription-coupled nucleotide excision repair (TC-NER) pathway to help remove lesions in the DNA that block transcription. Defects in this gene can cause UV-sensitive syndrome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Expression
Ubiquitous expression in testis (RPKM 2.2), spleen (RPKM 1.5) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
4p16.3
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (1342011..1395989)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (1340627..1394173)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (1340996..1381837)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374347 Neighboring gene uncharacterized LOC105374346 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15126 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15127 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:1285078-1285260 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:1288606-1289569 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:1291085-1291798 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:1301806-1302703 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:1303601-1304498 Neighboring gene macrophage erythroblast attacher, E3 ubiquitin ligase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:1311232-1311732 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:1317288-1318487 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:1319662-1320861 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:1332970-1333488 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:1338713-1339236 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:1339237-1339759 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15128 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15129 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15130 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21153 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:1344739-1344907 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:1353821-1354342 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:1354343-1354864 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:1388225-1389424 Neighboring gene Sharpr-MPRA regulatory region 8056 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:1399591-1400181 Neighboring gene Sharpr-MPRA regulatory region 3424 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:1408939-1409612 Neighboring gene NK1 homeobox 1 Neighboring gene uncharacterized LOC105374348

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Transcription coupled DNA repair protein UVSSA binds to DNA and RNA: Mapping of nucleic acid interaction sites on human UVSSA. Mistry H, et al. Arch Biochem Biophys, 2023 Feb. PMID 36623745
  2. UV-sensitive syndrome: Whole exome sequencing identified a nonsense mutation in the gene UVSSA in two consanguineous pedigrees from Pakistan. Ijaz A, et al. J Dermatol Sci, 2019 Sep. PMID 31421932
  3. [Molecular cloning and characterisation of UVSSA, the responsible gene for UV-sensitive syndrome]. Ogi T, et al. Seikagaku, 2013 Mar. PMID 23631307
  4. The UVSSA protein is part of a genome integrity homeostasis network with links to transcription-coupled DNA repair and ATM signaling. Kordon MM, et al. Proc Natl Acad Sci U S A, 2022 Mar 15. PMID 35254895, Free PMC Article
  5. The UVSSA complex alleviates MYC-driven transcription stress. Sato M, et al. J Cell Biol, 2021 Feb 1. PMID 33404608, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural characterization of transcription-coupled repair protein UVSSA and its interaction with TFIIH protein.
    Title: Structural characterization of transcription-coupled repair protein UVSSA and its interaction with TFIIH protein.
  2. Transcription coupled DNA repair protein UVSSA binds to DNA and RNA: Mapping of nucleic acid interaction sites on human UVSSA.
    Title: Transcription coupled DNA repair protein UVSSA binds to DNA and RNA: Mapping of nucleic acid interaction sites on human UVSSA.
  3. The UVSSA protein is part of a genome integrity homeostasis network with links to transcription-coupled DNA repair and ATM signaling.
    Title: The UVSSA protein is part of a genome integrity homeostasis network with links to transcription-coupled DNA repair and ATM signaling.
  4. The UVSSA complex alleviates MYC-driven transcription stress.
    Title: The UVSSA complex alleviates MYC-driven transcription stress.
  5. USP7-mediated deubiquitination differentially regulates CSB but not UVSSA upon UV radiation-induced DNA damage.
    Title: USP7-mediated deubiquitination differentially regulates CSB but not UVSSA upon UV radiation-induced DNA damage.
  6. TCR is initiated by RNAPIIo-bound CSB, which recruits CSA through a newly identified CSA-interaction motif (CIM); once recruited, CSA facilitates the association of UVSSA with stalled RNAPIIo; in addition, UVSSA is the key factor that recruits the TFIIH complex in a manner that is stimulated by CSB and CSA
    Title: The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II.
  7. Study reports nine UV-sensitive syndrome cases from two Pakistani families with a novel homozygous nonsense mutation, (c.1040 G > A [p.(Trp347*)]) in exon 6 of the UVSSA gene.
    Title: UV-sensitive syndrome: Whole exome sequencing identified a nonsense mutation in the gene UVSSA in two consanguineous pedigrees from Pakistan.
  8. FACT subunit Spt16 controls UVSSA recruitment to lesion-stalled RNA Pol II and stimulates transcription-coupled nucleotide excision repair.
    Title: FACT subunit Spt16 controls UVSSA recruitment to lesion-stalled RNA Pol II and stimulates TC-NER.
  9. UVSSA is mono-ubiquitinated in vitro. Lys(414) is the target of ubiquitination. Lys(414) was also modified by poly-ubiquitin chains in vivo. The substitution of Lys(414) by Arg of UVSSA inhibited its degradation and thereby suppressed the deficiency in transcription-coupled nucleotide excision repair.
    Title: Inhibition of UVSSA ubiquitination suppresses transcription-coupled nucleotide excision repair deficiency caused by dissociation from USP7.
  10. Data suggest that a common TFIIH subunit p62 recruitment mechanism is shared by UV-stimulated scaffold protein A (UVSSA) in transcription-coupled repair (TCR) and xeroderma pigmentosum, complementation group C protein (XPC) in global genome repair (GGR).
    Title: Common TFIIH recruitment mechanism in global genome and transcription-coupled repair subpathways.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
UV-sensitive syndrome 3
MedGen: C3553328 OMIM: 614640 GeneReviews: Not available
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EBI GWAS Catalog

Description
Joint influence of small-effect genetic variants on human longevity.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1530, MGC117169, AC078852.1

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA polymerase II complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II complex binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to UV IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to UV IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription-coupled nucleotide-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription-coupled nucleotide-excision repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in chromosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
UV-stimulated scaffold protein A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032753.2 RefSeqGene

    Range
    10199..51040
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001317934.2 → NP_001304863.1  UV-stimulated scaffold protein A

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC078852, AL390128, BC021930, BC110331
    Consensus CDS
    CCDS33938.1
    UniProtKB/Swiss-Prot
    A8K9E6, B2RU11, Q2YD98, Q8WTX4, Q9P1Z8
    UniProtKB/TrEMBL
    A0A7I2V554
    Related
    ENSP00000425130.1, ENST00000511216.6
    Conserved Domains (1) summary
    pfam09740
    Location:498 → 601
    DUF2043; Uncharacterized conserved protein (DUF2043)

  2. NM_001317935.2 → NP_001304864.1  UV-stimulated scaffold protein A

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC078852, AL390128, BC021930, BC110331, HY104489
    Consensus CDS
    CCDS33938.1
    UniProtKB/Swiss-Prot
    A8K9E6, B2RU11, Q2YD98, Q8WTX4, Q9P1Z8
    UniProtKB/TrEMBL
    A0A7I2V554
    Related
    ENSP00000421741.1, ENST00000507531.5
    Conserved Domains (1) summary
    pfam09740
    Location:498 → 601
    DUF2043; Uncharacterized conserved protein (DUF2043)

  3. NM_020894.4 → NP_065945.2  UV-stimulated scaffold protein A

    See identical proteins and their annotated locations for NP_065945.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AB040963, AC078852, AL390128, BC021930, BC110331, EL735271
    Consensus CDS
    CCDS33938.1
    UniProtKB/Swiss-Prot
    A8K9E6, B2RU11, Q2YD98, Q8WTX4, Q9P1Z8
    UniProtKB/TrEMBL
    A0A7I2V554
    Related
    ENSP00000374501.4, ENST00000389851.10
    Conserved Domains (1) summary
    pfam09740
    Location:498 → 601
    DUF2043; Uncharacterized conserved protein (DUF2043)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    1342011..1395989
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008493.3 → XP_016863982.1  UV-stimulated scaffold protein A isoform X2

    UniProtKB/Swiss-Prot
    A8K9E6, B2RU11, Q2YD98, Q8WTX4, Q9P1Z8
    UniProtKB/TrEMBL
    A0A7I2V554
    Related
    ENSP00000503948.1, ENST00000677286.1
    Conserved Domains (1) summary
    pfam09740
    Location:498 → 601
    DUF2043; Uncharacterized conserved protein (DUF2043)

  2. XM_047416025.1 → XP_047271981.1  UV-stimulated scaffold protein A isoform X1

  3. XM_047416026.1 → XP_047271982.1  UV-stimulated scaffold protein A isoform X1

    Related
    ENSP00000503485.1, ENST00000679242.1

  4. XM_017008498.3 → XP_016863987.1  UV-stimulated scaffold protein A isoform X7

  5. XM_047416028.1 → XP_047271984.1  UV-stimulated scaffold protein A isoform X9

    UniProtKB/TrEMBL
    A0A7I2V4K1
    Related
    ENSP00000504075.1, ENST00000678994.1

  6. XM_017008496.2 → XP_016863985.2  UV-stimulated scaffold protein A isoform X4

  7. XM_017008497.3 → XP_016863986.2  UV-stimulated scaffold protein A isoform X6

  8. XM_017008499.2 → XP_016863988.1  UV-stimulated scaffold protein A isoform X8

  9. XM_017008494.3 → XP_016863983.1  UV-stimulated scaffold protein A isoform X2

    UniProtKB/Swiss-Prot
    A8K9E6, B2RU11, Q2YD98, Q8WTX4, Q9P1Z8
    UniProtKB/TrEMBL
    A0A7I2V554
    Related
    ENSP00000504268.1, ENST00000677428.1
    Conserved Domains (1) summary
    pfam09740
    Location:498 → 601
    DUF2043; Uncharacterized conserved protein (DUF2043)

  10. XM_017008490.1 → XP_016863979.1  UV-stimulated scaffold protein A isoform X2

    UniProtKB/Swiss-Prot
    A8K9E6, B2RU11, Q2YD98, Q8WTX4, Q9P1Z8
    UniProtKB/TrEMBL
    A0A7I2V554
    Related
    ENSP00000504544.1, ENST00000679192.1
    Conserved Domains (1) summary
    pfam09740
    Location:498 → 601
    DUF2043; Uncharacterized conserved protein (DUF2043)

  11. XM_017008492.3 → XP_016863981.1  UV-stimulated scaffold protein A isoform X2

    UniProtKB/Swiss-Prot
    A8K9E6, B2RU11, Q2YD98, Q8WTX4, Q9P1Z8
    UniProtKB/TrEMBL
    A0A7I2V554
    Conserved Domains (1) summary
    pfam09740
    Location:498 → 601
    DUF2043; Uncharacterized conserved protein (DUF2043)

  12. XM_047416027.1 → XP_047271983.1  UV-stimulated scaffold protein A isoform X5

  13. XM_017008495.2 → XP_016863984.1  UV-stimulated scaffold protein A isoform X3

  14. XM_024454162.2 → XP_024309930.1  UV-stimulated scaffold protein A isoform X11

    Related
    ENSP00000427701.1, ENST00000512728.5
    Conserved Domains (1) summary
    pfam09740
    Location:49 → 152
    DUF2043; Uncharacterized conserved protein (DUF2043)

  15. XM_017008500.1 → XP_016863989.1  UV-stimulated scaffold protein A isoform X10

RNA

  1. XR_007057948.1 RNA Sequence

  2. XR_007057949.1 RNA Sequence

  3. XR_001741304.2 RNA Sequence

  4. XR_001741303.2 RNA Sequence

  5. XR_001741302.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    1340627..1394173
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054350621.1 → XP_054206596.1  UV-stimulated scaffold protein A isoform X2

    UniProtKB/Swiss-Prot
    A8K9E6, B2RU11, Q2YD98, Q8WTX4, Q9P1Z8

  2. XM_054350615.1 → XP_054206590.1  UV-stimulated scaffold protein A isoform X12

  3. XM_054350616.1 → XP_054206591.1  UV-stimulated scaffold protein A isoform X1

  4. XM_054350617.1 → XP_054206592.1  UV-stimulated scaffold protein A isoform X1

  5. XM_054350626.1 → XP_054206601.1  UV-stimulated scaffold protein A isoform X7

  6. XM_054350628.1 → XP_054206603.1  UV-stimulated scaffold protein A isoform X9

    UniProtKB/TrEMBL
    A0A7I2V4K1

  7. XM_054350623.1 → XP_054206598.1  UV-stimulated scaffold protein A isoform X4

  8. XM_054350625.1 → XP_054206600.1  UV-stimulated scaffold protein A isoform X6

  9. XM_054350627.1 → XP_054206602.1  UV-stimulated scaffold protein A isoform X8

  10. XM_054350619.1 → XP_054206594.1  UV-stimulated scaffold protein A isoform X2

    UniProtKB/Swiss-Prot
    A8K9E6, B2RU11, Q2YD98, Q8WTX4, Q9P1Z8

  11. XM_054350618.1 → XP_054206593.1  UV-stimulated scaffold protein A isoform X2

    UniProtKB/Swiss-Prot
    A8K9E6, B2RU11, Q2YD98, Q8WTX4, Q9P1Z8

  12. XM_054350620.1 → XP_054206595.1  UV-stimulated scaffold protein A isoform X2

    UniProtKB/Swiss-Prot
    A8K9E6, B2RU11, Q2YD98, Q8WTX4, Q9P1Z8

  13. XM_054350624.1 → XP_054206599.1  UV-stimulated scaffold protein A isoform X5

  14. XM_054350622.1 → XP_054206597.1  UV-stimulated scaffold protein A isoform X3

  15. XM_054350630.1 → XP_054206605.1  UV-stimulated scaffold protein A isoform X11

  16. XM_054350629.1 → XP_054206604.1  UV-stimulated scaffold protein A isoform X10

RNA

  1. XR_008487021.1 RNA Sequence

  2. XR_008487024.1 RNA Sequence

  3. XR_008487022.1 RNA Sequence

  4. XR_008487023.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2YD98.2 GenPept UniProtKB/Swiss-Prot:Q2YD98

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