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MIER1 MIER1 transcriptional regulator [ Homo sapiens (human) ]

Gene ID: 57708, updated on 25-Nov-2021

Summary

Official Symbol
MIER1provided by HGNC
Official Full Name
MIER1 transcriptional regulatorprovided by HGNC
Primary source
HGNC:HGNC:29657
See related
Ensembl:ENSG00000198160 MIM:616848
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ER1; MI-ER1
Summary
This gene encodes a protein that was first identified in Xenopus laevis by its role in a mesoderm induction early response (MIER). The encoded protein functions as a transcriptional regulator. Alternatively spliced transcript variants encode multiple isoforms, some of which lack a C-terminal nuclear localization signal. [provided by RefSeq, May 2013]
Expression
Ubiquitous expression in bone marrow (RPKM 19.6), colon (RPKM 10.3) and 24 other tissues See more
Orthologs
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Genomic context

See MIER1 in Genome Data Viewer
Location:
1p31.3
Exon count:
21
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (66924900..66988619)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (67390673..67454302)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene insulin like 5 Neighboring gene dynein axonemal intermediate chain 4 Neighboring gene solute carrier family 35 member D1 Neighboring gene chromosome 1 open reading frame 141 Neighboring gene interleukin 23 receptor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1610, MGC131940, MGC150640, MGC150641, DKFZp781G0451

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to histone deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables histone deacetylase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription repressor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mesoderm induction early response protein 1
Names
mesoderm induction early response 1 homolog
mesoderm induction early response 1, transcriptional regulator

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029847.1 RefSeqGene

    Range
    5096..68725
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001077700.3NP_001071168.2  mesoderm induction early response protein 1 isoform b

    See identical proteins and their annotated locations for NP_001071168.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region and uses an alternate upstream translation start site, compared to variant 1. The resulting isoform (b) has a longer and distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AK302061, AL500525, BM987758
    Consensus CDS
    CCDS53326.1
    UniProtKB/Swiss-Prot
    Q8N108
    Related
    ENSP00000383820.1, ENST00000401041.6
    Conserved Domains (2) summary
    cd11661
    Location:341385
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:235284
    ELM2; ELM2 domain
  2. NM_001077701.3NP_001071169.1  mesoderm induction early response protein 1 isoform c

    See identical proteins and their annotated locations for NP_001071169.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The resulting isoform (c, also known as N3-beta) has a shorter and distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AF515446, AL500525, BM987758
    Consensus CDS
    CCDS41348.1
    UniProtKB/Swiss-Prot
    Q8N108
    Related
    ENSP00000347514.3, ENST00000355356.3
    Conserved Domains (2) summary
    cd11661
    Location:288332
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:182231
    ELM2; ELM2 domain
  3. NM_001077702.3NP_001071170.2  mesoderm induction early response protein 1 isoform d precursor

    See identical proteins and their annotated locations for NP_001071170.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate segment in the 3' coding region, compared to variant 1. The resulting isoform (d) has a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AF515448, AK302061, AL500525, BM987758
    Consensus CDS
    CCDS53327.1
    UniProtKB/Swiss-Prot
    Q8N108
    Related
    ENSP00000360055.1, ENST00000371016.5
    Conserved Domains (2) summary
    cd11661
    Location:305349
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:199248
    ELM2; ELM2 domain
  4. NM_001077703.3NP_001071171.2  mesoderm induction early response protein 1 isoform e

    See identical proteins and their annotated locations for NP_001071171.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon in the 5' coding region, uses an alternate upstream translation start site, and lacks an alternate segment in the 3' coding region, compared to variant 1. The resulting isoform (e) has a longer and distinct N-terminus and a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK302061, AL500525, AY124187, BM987758
    Consensus CDS
    CCDS53325.1
    UniProtKB/Swiss-Prot
    Q8N108
    Related
    ENSP00000360053.1, ENST00000371014.5
    Conserved Domains (2) summary
    cd11661
    Location:341385
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:235284
    ELM2; ELM2 domain
  5. NM_001077704.3NP_001071172.1  mesoderm induction early response protein 1 isoform f

    See identical proteins and their annotated locations for NP_001071172.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at an alternate start codon, and lacks an alternate segment in the 3' coding region, compared to variant 1. The resulting isoform (f, also known as N3-alpha), has shorter and distinct N- and C-termini, compared to isoform a.
    Source sequence(s)
    AL500525, AY124188, BM987758
    Consensus CDS
    CCDS41347.1
    UniProtKB/Swiss-Prot
    Q8N108
    Related
    ENSP00000383821.3, ENST00000401042.7
    Conserved Domains (2) summary
    cd11661
    Location:288332
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:182231
    ELM2; ELM2 domain
  6. NM_001146110.2NP_001139582.1  mesoderm induction early response protein 1 isoform a precursor

    See identical proteins and their annotated locations for NP_001139582.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) uses an alternate splice site in the 5' UTR compared to variant 1. Both variants 1 and 10 encode the same isoform (a).
    Source sequence(s)
    AK302061, AK307717, AL500525, BC108726, BM987758
    Consensus CDS
    CCDS53329.1
    UniProtKB/Swiss-Prot
    Q8N108
    Related
    ENSP00000350321.2, ENST00000357692.6
    Conserved Domains (2) summary
    cd11661
    Location:305349
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:199248
    ELM2; ELM2 domain
  7. NM_001146111.2NP_001139583.1  mesoderm induction early response protein 1 isoform g precursor

    See identical proteins and their annotated locations for NP_001139583.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks an alternate segment in the 3' coding region, compared to variant 1. The resulting isoform (g) has a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK302061, AL500525, BC108726, BM987758
    Consensus CDS
    CCDS53328.1
    UniProtKB/Swiss-Prot
    Q8N108
    Related
    ENSP00000360057.3, ENST00000371018.7
    Conserved Domains (2) summary
    cd11661
    Location:305349
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:199248
    ELM2; ELM2 domain
  8. NM_001146112.2NP_001139584.1  mesoderm induction early response protein 1 isoform h

    See identical proteins and their annotated locations for NP_001139584.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks a portion of the 5' coding region and initiates translation at a downstream in-frame start codon, compared to variant 1. The resulting isoform (h) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AF515446, AK302061, AL139216, AL500525, BM987758
    UniProtKB/Swiss-Prot
    Q8N108
    Conserved Domains (2) summary
    cd11661
    Location:261305
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:155204
    ELM2; ELM2 domain
  9. NM_001146113.2NP_001139585.1  mesoderm induction early response protein 1 isoform i

    See identical proteins and their annotated locations for NP_001139585.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) lacks two alternate exons in the 5' coding region, initiates translation at a downsteram in-frame start codon, and lacks an alternate segment in the 3' coding region, compared to variant 1. The resulting isoform (i) has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK302061, AL500525, BC125217, BM987758
    Consensus CDS
    CCDS53330.1
    UniProtKB/Swiss-Prot
    Q8N108
    Related
    ENSP00000348253.6, ENST00000355977.10
    Conserved Domains (2) summary
    cd11661
    Location:225269
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:119168
    ELM2; ELM2 domain
  10. NM_001278215.2NP_001265144.1  mesoderm induction early response protein 1 isoform j precursor

    See identical proteins and their annotated locations for NP_001265144.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) lacks multiple 3' exons and its transcription extends past a splice site used in variant 1, resulting in a distinct 3' coding region and 3' UTR. The encoded isoform (j) has a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AL139216, BC066898
    Consensus CDS
    CCDS60163.1
    UniProtKB/Swiss-Prot
    Q8N108
    Related
    ENSP00000360051.2, ENST00000371012.6
  11. NM_001350530.2NP_001337459.1  mesoderm induction early response protein 1 isoform k

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) contains an alternate exon in its 5' coding region, resulting in a shorter 5' UTR and the use of an alternate upstream translation start site, compared to variant 1. The resulting isoform (k) has a longer and distinct N-terminus, compared to isoform a
    Source sequence(s)
    AF515448, AK302061, AL139216, AL500525, BM987758, CB998535
    Conserved Domains (2) summary
    cd11661
    Location:378422
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:272321
    ELM2; ELM2 domain
  12. NM_020948.4NP_065999.2  mesoderm induction early response protein 1 isoform a precursor

    See identical proteins and their annotated locations for NP_065999.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a. Both variants 1 and 10 encode the same isoform (a).
    Source sequence(s)
    AF515448, AK302061, AL500525, BM987758
    Consensus CDS
    CCDS53329.1
    UniProtKB/Swiss-Prot
    Q8N108
    Conserved Domains (2) summary
    cd11661
    Location:305349
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:199248
    ELM2; ELM2 domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    66924900..66988619
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001932.1XP_016857421.1  mesoderm induction early response protein 1 isoform X9

  2. XM_017001921.1XP_016857410.1  mesoderm induction early response protein 1 isoform X3

    Conserved Domains (2) summary
    cd11661
    Location:321365
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:215264
    ELM2; ELM2 domain
  3. XM_017001923.1XP_016857412.1  mesoderm induction early response protein 1 isoform X4

  4. XM_011541865.2XP_011540167.1  mesoderm induction early response protein 1 isoform X1

    Conserved Domains (3) summary
    smart00717
    Location:365410
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11661
    Location:365409
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:259308
    ELM2; ELM2 domain
  5. XM_017001929.1XP_016857418.1  mesoderm induction early response protein 1 isoform X7

    Conserved Domains (2) summary
    cd11661
    Location:287331
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:181230
    ELM2; ELM2 domain
  6. XM_017001926.1XP_016857415.1  mesoderm induction early response protein 1 isoform X5

    UniProtKB/Swiss-Prot
    Q8N108
    Conserved Domains (2) summary
    cd11661
    Location:305349
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:199248
    ELM2; ELM2 domain
  7. XM_017001924.1XP_016857413.1  mesoderm induction early response protein 1 isoform X5

    UniProtKB/Swiss-Prot
    Q8N108
    Conserved Domains (2) summary
    cd11661
    Location:305349
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:199248
    ELM2; ELM2 domain
  8. XM_005271076.3XP_005271133.1  mesoderm induction early response protein 1 isoform X5

    See identical proteins and their annotated locations for XP_005271133.1

    UniProtKB/Swiss-Prot
    Q8N108
    Conserved Domains (2) summary
    cd11661
    Location:305349
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:199248
    ELM2; ELM2 domain
  9. XM_017001919.1XP_016857408.1  mesoderm induction early response protein 1 isoform X2

    Conserved Domains (3) summary
    smart00717
    Location:324369
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11661
    Location:324368
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:218267
    ELM2; ELM2 domain
  10. XM_017001931.1XP_016857420.1  mesoderm induction early response protein 1 isoform X8

    UniProtKB/Swiss-Prot
    Q8N108
    Conserved Domains (2) summary
    cd11661
    Location:261305
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:155204
    ELM2; ELM2 domain
  11. XM_017001927.1XP_016857416.1  mesoderm induction early response protein 1 isoform X6

    UniProtKB/Swiss-Prot
    Q8N108
    Conserved Domains (2) summary
    cd11661
    Location:287331
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:181230
    ELM2; ELM2 domain
  12. XM_017001928.2XP_016857417.1  mesoderm induction early response protein 1 isoform X6

    UniProtKB/Swiss-Prot
    Q8N108
    Conserved Domains (2) summary
    cd11661
    Location:287331
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:181230
    ELM2; ELM2 domain
  13. XM_017001925.1XP_016857414.1  mesoderm induction early response protein 1 isoform X5

    UniProtKB/Swiss-Prot
    Q8N108
    Conserved Domains (2) summary
    cd11661
    Location:305349
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:199248
    ELM2; ELM2 domain
  14. XM_017001922.1XP_016857411.1  mesoderm induction early response protein 1 isoform X3

    Conserved Domains (2) summary
    cd11661
    Location:321365
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:215264
    ELM2; ELM2 domain
  15. XM_017001920.1XP_016857409.1  mesoderm induction early response protein 1 isoform X2

    Conserved Domains (3) summary
    smart00717
    Location:324369
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11661
    Location:324368
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:218267
    ELM2; ELM2 domain
  16. XM_017001930.1XP_016857419.1  mesoderm induction early response protein 1 isoform X7

    Conserved Domains (2) summary
    cd11661
    Location:287331
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:181230
    ELM2; ELM2 domain
  17. XM_017001933.1XP_016857422.1  mesoderm induction early response protein 1 isoform X9

  18. XM_017001934.1XP_016857423.1  mesoderm induction early response protein 1 isoform X9

RNA

  1. XR_001737345.1 RNA Sequence

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