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Slc15a2 solute carrier family 15 (H+/peptide transporter), member 2 [ Mus musculus (house mouse) ]

Gene ID: 57738, updated on 21-Apr-2024

Summary

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Official Symbol
Slc15a2provided by MGI
Official Full Name
solute carrier family 15 (H+/peptide transporter), member 2provided by MGI
Primary source
MGI:MGI:1890457
See related
Ensembl:ENSMUSG00000022899 AllianceGenome:MGI:1890457
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pept2; 8430408C16Rik
Summary
Enables dipeptide transmembrane transporter activity and high-affinity oligopeptide transmembrane transporter activity. Involved in several processes, including dipeptide import across plasma membrane; peptidoglycan transport; and regulation of nucleotide-binding activity oligomerization domain containing signaling pathway. Acts upstream of or within oligopeptide transport. Located in membrane. Is integral component of plasma membrane. Is expressed in several structures, including genitourinary system; integumental system; nervous system; nose; and respiratory system. Orthologous to human SLC15A2 (solute carrier family 15 member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney adult (RPKM 7.8), frontal lobe adult (RPKM 3.5) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 B3; 16 25.97 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (36570523..36605506, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (36750161..36785158, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40772 Neighboring gene STARR-positive B cell enhancer mm9_chr16:36711953-36712254 Neighboring gene immunoglobulin-like domain containing receptor 1 Neighboring gene STARR-seq mESC enhancer starr_40773 Neighboring gene RNA guanylyltransferase and 5'-phosphatase pseudogene Neighboring gene STARR-seq mESC enhancer starr_40774 Neighboring gene 60S ribosomal protein L7a pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E764 Neighboring gene ELL associated factor 2 Neighboring gene STARR-positive B cell enhancer ABC_E1185 Neighboring gene STARR-positive B cell enhancer ABC_E10903 Neighboring gene IQ calmodulin-binding motif containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E5541 Neighboring gene STARR-positive B cell enhancer ABC_E99 Neighboring gene RIKEN cDNA 4930565N06 gene Neighboring gene STARR-positive B cell enhancer mm9_chr16:36884785-36885086 Neighboring gene golgin B1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Importance of Peptide transporter 2 on the cerebrospinal fluid efflux kinetics of glycylsarcosine characterized by nonlinear mixed effects modeling. Huh Y, et al. Pharm Res, 2013 May. PMID 23371515, Free PMC Article
  2. Mouse endogenous retroviruses can trigger premature transcriptional termination at a distance. Li J, et al. Genome Res, 2012 May. PMID 22367191, Free PMC Article
  3. Kyotorphin transport and metabolism in rat and mouse neonatal astrocytes. Xiang J, et al. Brain Res, 2010 Aug 6. PMID 20537989, Free PMC Article
  4. Enhanced antinociceptive response to intracerebroventricular kyotorphin in Pept2 null mice. Jiang H, et al. J Neurochem, 2009 Jun. PMID 19383084, Free PMC Article
  5. Influence of genetic knockout of Pept2 on the in vivo disposition of endogenous and exogenous carnosine in wild-type and Pept2 null mice. Kamal MA, et al. Am J Physiol Regul Integr Comp Physiol, 2009 Apr. PMID 19225147, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. this study shows that SLC15A2 mediates the transport of bacterially derived di/tripeptides to enhance the nucleotide-binding oligomerization domain-dependent immune response in mouse bone marrow-derived macrophages
    Title: SLC15A2 and SLC15A4 Mediate the Transport of Bacterially Derived Di/Tripeptides To Enhance the Nucleotide-Binding Oligomerization Domain-Dependent Immune Response in Mouse Bone Marrow-Derived Macrophages.
  2. We found marked changes in protein expression and functional activity of PhT1 and PepT2, the former predominating in adult and the latter in neonate
    Title: Divergent developmental expression and function of the proton-coupled oligopeptide transporters PepT2 and PhT1 in regional brain slices of mouse and rat.
  3. JAK3 is a powerful regulator of the peptide transporters PEPT1 and PEPT2.
    Title: Effect of Janus kinase 3 on the peptide transporters PEPT1 and PEPT2.
  4. The study presents a pharmacokinetic model to quantitate the distribution kinetics of glycylsarcosine, a substrate of PepT2, in blood, cerebrospinal fluid and kidney in wild-type and PepT2 knockout mice.
    Title: Importance of Peptide transporter 2 on the cerebrospinal fluid efflux kinetics of glycylsarcosine characterized by nonlinear mixed effects modeling.
  5. Report influence of genetic knockout of Pept2 on the in vivo disposition of endogenous and exogenous carnosine in wild-type and Pept2 null mice.
    Title: Influence of genetic knockout of Pept2 on the in vivo disposition of endogenous and exogenous carnosine in wild-type and Pept2 null mice.
  6. PEPT2 to be the dominant transporter for the reabsorption of di- and tripeptides and its pharmacological substrates in the organism, and for the removal of these substrates from the cerebrospinal fluid
    Title: Peptide transporters and their roles in physiological processes and drug disposition.
  7. Astrocytes from neonatal PEPT2-/- mice had reduced ALA and carnosine uptake compared to PEPT2+/+ mice. Results demonstrate that PEPT2 is the primary transporter responsible for the astrocytic uptake of ALA and carnosine.
    Title: PEPT2-mediated transport of 5-aminolevulinic acid and carnosine in astrocytes.
  8. PEPT2 is the main system responsible for tubular reabsorption of peptide-bound amino acids, although this does not lead to major changes in renal excretion of protein or free amino acids.
    Title: Targeted disruption of the peptide transporter Pept2 gene in mice defines its physiological role in the kidney.
  9. PEPT2 is responsible for dipeptide uptake in choroid plexus tissue
    Title: Targeted disruption of the PEPT2 gene markedly reduces dipeptide uptake in choroid plexus.
  10. Peptide transport in the mammary gland
    Title: Peptide transport in the mammary gland: expression and distribution of PEPT2 mRNA and protein.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dipeptide transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dipeptide transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables dipeptide transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables high-affinity oligopeptide transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptide:proton symporter activity ISO
Inferred from Sequence Orthology
more info
  
enables tripeptide transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in antibacterial innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in dipeptide import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dipeptide import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dipeptide import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in dipeptide transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dipeptide transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within oligopeptide transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidoglycan transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in renal absorption IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tripeptide import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in xenobiotic transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in phagocytic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
solute carrier family 15 member 2
Names
kidney H(+)/peptide cotransporter
peptide transporter 2
proton-dependent high affinity oligopeptide transporter PepT2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145899.2 → NP_001139371.2  solute carrier family 15 member 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate segment at the 3' end compared to variant 1, which results in a frameshift, and a shorter isoform (2) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC117662, AEKQ02018542
    Consensus CDS
    CCDS49842.1
    UniProtKB/TrEMBL
    E9Q329, Q80XC0, Q9CXC0
    Related
    ENSMUSP00000132029.3, ENSMUST00000164579.9
    Conserved Domains (1) summary
    cl28910
    Location:54 → 243
    MFS; Major Facilitator Superfamily

  2. NM_021301.4 → NP_067276.3  solute carrier family 15 member 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC117662, AEKQ02018542
    Consensus CDS
    CCDS28156.1
    UniProtKB/Swiss-Prot
    Q9ES07
    UniProtKB/TrEMBL
    E9QMN8, Q9JM03
    Related
    ENSMUSP00000023616.4, ENSMUST00000023616.11
    Conserved Domains (1) summary
    TIGR00926
    Location:69 → 707
    2A1704; Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    36570523..36605506 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522430.4 → XP_006522493.1  solute carrier family 15 member 2 isoform X1

    See identical proteins and their annotated locations for XP_006522493.1

    Conserved Domains (1) summary
    TIGR00926
    Location:2 → 403
    2A1704; Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors)

RNA

  1. XR_003951808.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ES07.1 GenPept UniProtKB/Swiss-Prot:Q9ES07

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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