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Abhd1 abhydrolase domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 57742, updated on 8-Feb-2024

Summary

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Official Symbol
Abhd1provided by MGI
Official Full Name
abhydrolase domain containing 1provided by MGI
Primary source
MGI:MGI:1931013
See related
Ensembl:ENSMUSG00000006638 AllianceGenome:MGI:1931013
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LABH1; LABH-1
Summary
Predicted to enable acetylesterase activity and acylglycerol lipase activity. Predicted to be involved in medium-chain fatty acid biosynthetic process and medium-chain fatty acid catabolic process. Is expressed in several structures, including clavicle; genitourinary system; liver; meninges; and thymus primordium. Orthologous to human ABHD1 (abhydrolase domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Expression
Ubiquitous expression in small intestine adult (RPKM 30.2), duodenum adult (RPKM 28.3) and 28 other tissues See more
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Genomic context

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Location:
5 B1; 5 16.9 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (31107410..31112439)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (30950066..30955095)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4749 Neighboring gene ketohexokinase Neighboring gene cell growth regulator with EF hand domain 1 Neighboring gene STARR-positive B cell enhancer ABC_E1679 Neighboring gene prolactin regulatory element binding Neighboring gene transcription factor 23 Neighboring gene STARR-seq mESC enhancer starr_12765 Neighboring gene solute carrier family 5 (sodium-dependent vitamin transporter), member 6 Neighboring gene STARR-positive B cell enhancer ABC_E2741 Neighboring gene all-trans retinoic acid induced differentiation factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Alpha/beta hydrolase 1 is upregulated in D5 dopamine receptor knockout mice and reduces O2- production of NADPH oxidase. Stoelting M, et al. Biochem Biophys Res Commun, 2009 Jan 30. PMID 19073140
  2. Cloning and tissue distribution of three murine alpha/beta hydrolase fold protein cDNAs. Edgar AJ, et al. Biochem Biophys Res Commun, 2002 Apr 5. PMID 11922611
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The mRNA level of alpha/beta hydrolase 1 (ABHD1) is significantly upregulated in D5-/- mice.
    Title: Alpha/beta hydrolase 1 is upregulated in D5 dopamine receptor knockout mice and reduces O2- production of NADPH oxidase.
  2. LABH-1 protein is a member of a novel family of membrane bound enzymes whose function has yet to be determined; highest expression level in the liver
    Title: Cloning and tissue distribution of three murine alpha/beta hydrolase fold protein cDNAs.
Submit: New GeneRIF Correction

General gene information

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Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetylesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acylglycerol lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in medium-chain fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in medium-chain fatty acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein ABHD1
Names
abhydrolase domain-containing protein 1
alpha/beta hydrolase domain-containing protein 1
alpha/beta hydrolase-1
lung alpha/beta hydrolase 1
mmLABH1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021304.3 → NP_067279.2  protein ABHD1

    See identical proteins and their annotated locations for NP_067279.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript expressed in NOD strain.
    Source sequence(s)
    BC013505
    UniProtKB/Swiss-Prot
    Q9QZC8
    Conserved Domains (2) summary
    pfam00561
    Location:131 → 372
    Abhydrolase_1; alpha/beta hydrolase fold
    cl21494
    Location:54 → 381
    Abhydrolase; alpha/beta hydrolases

RNA

  1. NR_003522.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the transcript expressed in C57BL/6J.
    Source sequence(s)
    AA467032, AC109606, AK162873, CK789386, CK791402
    Related
    ENSMUST00000201125.4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    31107410..31112439
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QZC8.2 GenPept UniProtKB/Swiss-Prot:Q9QZC8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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