Format

Send to:

Choose Destination

Tnip1 TNFAIP3 interacting protein 1 [ Mus musculus (house mouse) ]

Gene ID: 57783, updated on 26-Sep-2021

Summary

Official Symbol
Tnip1provided by MGI
Official Full Name
TNFAIP3 interacting protein 1provided by MGI
Primary source
MGI:MGI:1926194
See related
Ensembl:ENSMUSG00000020400
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AB; Ne; Nef; VAN; ABIN; Naf1; ABIN1; ABIN-1; AU018810
Expression
Ubiquitous expression in colon adult (RPKM 26.8), duodenum adult (RPKM 23.7) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Tnip1 in Genome Data Viewer
Location:
11; 11 B1.3
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (54801613..54853766, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (54910787..54962956, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (54724289..54776440, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1343 Neighboring gene glutathione peroxidase 3 Neighboring gene 40S ribosomal protein S11-like Neighboring gene annexin A6 Neighboring gene predicted gene, 19911 Neighboring gene coiled-coil domain containing 69

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (7)  1 citation
  • Chemically induced (ENU) (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables mitogen-activated protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables mitogen-activated protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables polyubiquitin modification-dependent protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in MyD88-dependent toll-like receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glycoprotein biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in leukocyte cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein deubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
TNFAIP3-interacting protein 1
Names
A20-binding inhibitor of NF-kappa B activation
Nef-associated factor 1
virion-associated nuclear shuttling protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199275.2NP_001186204.1  TNFAIP3-interacting protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001186204.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AL593846
    Consensus CDS
    CCDS24704.1
    UniProtKB/TrEMBL
    E9QM75
    Related
    ENSMUSP00000099792.2, ENSMUST00000102731.8
    Conserved Domains (2) summary
    COG1196
    Location:311542
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl19252
    Location:227264
    MreC; rod shape-determining protein MreC
  2. NM_001199276.2NP_001186205.1  TNFAIP3-interacting protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001186205.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 3 and 4 encode the same isoform (2).
    Source sequence(s)
    AL593846
    Consensus CDS
    CCDS56769.1
    UniProtKB/Swiss-Prot
    Q9WUU8
    Related
    ENSMUSP00000104514.2, ENSMUST00000108886.8
    Conserved Domains (2) summary
    COG1196
    Location:258489
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl19252
    Location:174211
    MreC; rod shape-determining protein MreC
  3. NM_001271455.1NP_001258384.1  TNFAIP3-interacting protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001258384.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 3 and 4 encode the same isoform (2).
    Source sequence(s)
    AL593846
    Consensus CDS
    CCDS56769.1
    UniProtKB/Swiss-Prot
    Q9WUU8
    Related
    ENSMUSP00000104513.2, ENSMUST00000108885.8
    Conserved Domains (2) summary
    COG1196
    Location:258489
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl19252
    Location:174211
    MreC; rod shape-determining protein MreC
  4. NM_001271456.1NP_001258385.1  TNFAIP3-interacting protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001258385.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL593846
    Consensus CDS
    CCDS70188.1
    UniProtKB/TrEMBL
    D3Z2W0
    Related
    ENSMUSP00000099791.3, ENSMUST00000102730.9
    Conserved Domains (2) summary
    COG1196
    Location:311542
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl19252
    Location:227264
    MreC; rod shape-determining protein MreC
  5. NM_021327.4NP_067302.2  TNFAIP3-interacting protein 1 isoform 1

    See identical proteins and their annotated locations for NP_067302.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AL593846
    Consensus CDS
    CCDS24704.1
    UniProtKB/TrEMBL
    E9QM75
    Related
    ENSMUSP00000018482.7, ENSMUST00000018482.13
    Conserved Domains (2) summary
    COG1196
    Location:311542
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl19252
    Location:227264
    MreC; rod shape-determining protein MreC

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    54801613..54853766 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249162.1XP_011247464.1  TNFAIP3-interacting protein 1 isoform X2

    See identical proteins and their annotated locations for XP_011247464.1

    UniProtKB/TrEMBL
    D3Z2W0
    Conserved Domains (2) summary
    COG1196
    Location:311542
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl19252
    Location:227264
    MreC; rod shape-determining protein MreC
  2. XM_030246197.2XP_030102057.1  TNFAIP3-interacting protein 1 isoform X4

    Conserved Domains (2) summary
    COG1196
    Location:258489
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl19252
    Location:174211
    MreC; rod shape-determining protein MreC
  3. XM_011249163.4XP_011247465.1  TNFAIP3-interacting protein 1 isoform X3

    See identical proteins and their annotated locations for XP_011247465.1

    UniProtKB/Swiss-Prot
    Q9WUU8
    Conserved Domains (2) summary
    COG1196
    Location:258489
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl19252
    Location:174211
    MreC; rod shape-determining protein MreC
  4. XM_030246199.1XP_030102059.1  TNFAIP3-interacting protein 1 isoform X6

    Conserved Domains (2) summary
    COG1196
    Location:225456
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl19252
    Location:141178
    MreC; rod shape-determining protein MreC
  5. XM_006533848.3XP_006533911.1  TNFAIP3-interacting protein 1 isoform X5

    See identical proteins and their annotated locations for XP_006533911.1

    Conserved Domains (2) summary
    COG1196
    Location:225456
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl19252
    Location:141178
    MreC; rod shape-determining protein MreC
  6. XM_011249164.3XP_011247466.1  TNFAIP3-interacting protein 1 isoform X5

    See identical proteins and their annotated locations for XP_011247466.1

    Conserved Domains (2) summary
    COG1196
    Location:225456
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl19252
    Location:141178
    MreC; rod shape-determining protein MreC
  7. XM_006533847.5XP_006533910.1  TNFAIP3-interacting protein 1 isoform X3

    See identical proteins and their annotated locations for XP_006533910.1

    UniProtKB/Swiss-Prot
    Q9WUU8
    Conserved Domains (2) summary
    COG1196
    Location:258489
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl19252
    Location:174211
    MreC; rod shape-determining protein MreC
  8. XM_030246196.2XP_030102056.1  TNFAIP3-interacting protein 1 isoform X2

    Conserved Domains (2) summary
    COG1196
    Location:311542
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl19252
    Location:227264
    MreC; rod shape-determining protein MreC
  9. XM_006533846.5XP_006533909.1  TNFAIP3-interacting protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006533909.1

    UniProtKB/TrEMBL
    E9QM75
    Related
    ENSMUSP00000104517.4, ENSMUST00000108889.10
    Conserved Domains (2) summary
    COG1196
    Location:311542
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl19252
    Location:227264
    MreC; rod shape-determining protein MreC
Support Center