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Rpl35a ribosomal protein L35A [ Rattus norvegicus (Norway rat) ]

Gene ID: 57809, updated on 11-Apr-2024

Summary

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Official Symbol
Rpl35aprovided by RGD
Official Full Name
ribosomal protein L35Aprovided by RGD
Primary source
RGD:2323795
See related
Ensembl:ENSRNOG00000064222 AllianceGenome:RGD:2323795
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rpl35al1
Summary
Enables ribonucleoprotein complex binding activity. Predicted to be involved in rRNA processing and ribosomal large subunit biogenesis. Part of cytosolic large ribosomal subunit. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 5. Orthologous to human RPL35A (ribosomal protein L35a). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 2780.3), Spleen (RPKM 2675.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
11q22
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (81231114..81235094, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (67726031..67729953, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (7186459..7186874, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481083 Neighboring gene oxysterol binding protein-like 11 Neighboring gene leishmanolysin like peptidase Neighboring gene IQ motif containing G Neighboring gene leucine rich repeats and calponin homology domain containing 3 Neighboring gene uncharacterized LOC134481085

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The identification by affinity chromatography of the rat liver ribosomal proteins that bind to elongator and initiator transfer ribonucleic acids. Ulbrich N, et al. J Biol Chem, 1980 Jul 25. PMID 7391064
  2. Identification by affinity chromatography of the rat liver ribosomal proteins that bind to Escherichia coli 5 S ribosomal ribonucleic acid. Ulbrich N, et al. J Biol Chem, 1980 Jan 25. PMID 6985899
  3. Abnormalities of the large ribosomal subunit protein, Rpl35a, in Diamond-Blackfan anemia. Farrar JE, et al. Blood, 2008 Sep 1. PMID 18535205, Free PMC Article
  4. The identification of novel therapeutic targets for the treatment of malignant brain tumors. Kroes RA, et al. Cancer Lett, 2000 Aug 11. PMID 10880769
  5. Nucleotide sequence of cloned cDNA specific for rat ribosomal protein L35a. Tanaka T, et al. Eur J Biochem, 1986 Feb 3. PMID 3753935

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC72845

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ribonucleoprotein complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
  
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in rRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosomal large subunit biogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
located_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
large ribosomal subunit protein eL33
Names
60S ribosomal protein L35a
ribosomal protein L35a-like
ribosomal protein L35a-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021264.4 → NP_067087.1  large ribosomal subunit protein eL33

    See identical proteins and their annotated locations for NP_067087.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/Swiss-Prot
    P04646
    UniProtKB/TrEMBL
    A0A8L2QJQ6, A6IRM5
    Related
    ENSRNOP00000095237.1, ENSRNOT00000106141.1
    Conserved Domains (1) summary
    pfam01247
    Location:5 → 103
    Ribosomal_L35Ae; Ribosomal protein L35Ae

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    81231114..81235094 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270728.1 → XP_063126798.1  large ribosomal subunit protein eL33 isoform X2

    UniProtKB/TrEMBL
    A0A8I6GKL5

  2. XM_063270732.1 → XP_063126802.1  large ribosomal subunit protein eL33 isoform X3

  3. XM_063270723.1 → XP_063126793.1  large ribosomal subunit protein eL33 isoform X1

  4. XM_002727895.7 → XP_002727941.1  large ribosomal subunit protein eL33 isoform X4

    See identical proteins and their annotated locations for XP_002727941.1

    UniProtKB/Swiss-Prot
    P04646
    UniProtKB/TrEMBL
    A0A8L2QJQ6, A6IRM5
    Conserved Domains (1) summary
    pfam01247
    Location:5 → 103
    Ribosomal_L35Ae; Ribosomal protein L35Ae

  5. XM_063270729.1 → XP_063126799.1  large ribosomal subunit protein eL33 isoform X2

    UniProtKB/TrEMBL
    A0A8I6GKL5

  6. XM_063270724.1 → XP_063126794.1  large ribosomal subunit protein eL33 isoform X1

  7. XM_063270735.1 → XP_063126805.1  large ribosomal subunit protein eL33 isoform X4

    UniProtKB/Swiss-Prot
    P04646
    UniProtKB/TrEMBL
    A6IRM5

  8. XM_063270734.1 → XP_063126804.1  large ribosomal subunit protein eL33 isoform X4

    UniProtKB/Swiss-Prot
    P04646
    UniProtKB/TrEMBL
    A6IRM5

  9. XM_063270727.1 → XP_063126797.1  large ribosomal subunit protein eL33 isoform X1

  10. XM_063270730.1 → XP_063126800.1  large ribosomal subunit protein eL33 isoform X2

    UniProtKB/TrEMBL
    A0A8I6GKL5

  11. XM_063270726.1 → XP_063126796.1  large ribosomal subunit protein eL33 isoform X1

  12. XM_063270725.1 → XP_063126795.1  large ribosomal subunit protein eL33 isoform X1

  13. XM_063270731.1 → XP_063126801.1  large ribosomal subunit protein eL33 isoform X2

    UniProtKB/TrEMBL
    A0A8I6GKL5

  14. XM_063270733.1 → XP_063126803.1  large ribosomal subunit protein eL33 isoform X4

    UniProtKB/Swiss-Prot
    P04646
    UniProtKB/TrEMBL
    A6IRM5
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P04646.1 GenPept UniProtKB/Swiss-Prot:P04646

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