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tbx20 T-box transcription factor 20 [ Danio rerio (zebrafish) ]

Gene ID: 57936, updated on 25-Jan-2022

Summary

Official Symbol
tbx20provided by ZNC
Official Full Name
T-box transcription factor 20provided by ZNC
Primary source
ZFIN:ZDB-GENE-000427-7
See related
Ensembl:ENSDARG00000005150 AllianceGenome:ZFIN:ZDB-GENE-000427-7
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
hrt; whz; cb826; ZF-TBX20
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including circulatory system development; cloaca development; and regulation of cardiac muscle cell proliferation. Predicted to be located in nucleus. Is expressed in several structures, including cardiovascular system; digestive system; integument; mesoderm; and nervous system. Human ortholog(s) of this gene implicated in atrial heart septal defect 4. Orthologous to human TBX20 (T-box transcription factor 20). [provided by Alliance of Genome Resources, Nov 2021]
Orthologs
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Genomic context

See tbx20 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (42505025..42523910, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (42605255..42619962, complement)
103 previous assembly Zv9 (GCF_000002035.4) 16 NC_007127.5 (45280074..45295076, complement)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene HERPUD family member 2 Neighboring gene protein kinase-like domain containing Neighboring gene dpy-19-like 1, like (H. sapiens) Neighboring gene solute carrier family 4 member 7

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cardiac muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell fate specification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cloaca development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic heart tube development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart development IEP
Inferred from Expression Pattern
more info
 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heart looping IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within heart looping IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart rudiment development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cardiac muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
involved_in vasculogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
T-box transcription factor TBX20
Names
H15-related T-box transcription factor hrT
T-box 20
T-box protein 20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131506.2NP_571581.2  T-box transcription factor TBX20

    See identical proteins and their annotated locations for NP_571581.2

    Status: VALIDATED

    Source sequence(s)
    AF239664
    UniProtKB/Swiss-Prot
    Q9I9K7
    UniProtKB/TrEMBL
    B3DJG4
    Related
    ENSDARP00000026669.7, ENSDART00000017185.8
    Conserved Domains (1) summary
    cd00182
    Location:98290
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    42505025..42523910 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021466746.1XP_021322421.1  T-box transcription factor TBX20 isoform X1

    Conserved Domains (1) summary
    pfam00907
    Location:101287
    T-box
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