hand2 heart and neural crest derivatives expressed 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hand2provided by ZNC
Official Full Name: heart and neural crest derivatives expressed 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-000511-1
See related: Ensembl:ENSDARG00000008305 AllianceGenome:ZFIN:ZDB-GENE-000511-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: han; dhand; zdHAND; zgc:103415
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including animal organ development; determination of intestine left/right asymmetry; and nervous system development. Predicted to be located in nucleus. Is expressed in several structures, including cardiovascular system; digestive system; head; mesoderm; and pectoral fin. Orthologous to human HAND2 (heart and neural crest derivatives expressed 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (38193147..38195012, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (37473969..37475834, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma.
Title: Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma.
Cardiac Na(+)-Ca(2+) exchanger 1 (ncx1h) is critical for the ventricular cardiomyocyte formation via regulating the expression levels of gata4 and hand2 in zebrafish.
Title: Cardiac Na(+)-Ca(2+) exchanger 1 (ncx1h) is critical for the ventricular cardiomyocyte formation via regulating the expression levels of gata4 and hand2 in zebrafish.
Results found that hand2 expression is regulated by the alternate splice transcript jnk1a to determine first heart field ventricular cardiomyocytes.
Title: Alternative splicing of jnk1a in zebrafish determines first heart field ventricular cardiomyocyte numbers through modulation of hand2 expression.
hand2 and the co-expressed zinc-finger transcription factor osr1 have functionally antagonistic influences on kidney development. Together, our data suggest that hand2 functions in opposition to osr1 to balance the formation of kidney and vein progenitors by regulating cell fate decisions at the lateral boundary of the Iintermediate mesoderm
Title: Hand2 inhibits kidney specification while promoting vein formation within the posterior mesoderm.
hand2 can drive cardiomyocyte production in multiple contexts and through multiple mechanisms
Title: Hand2 elevates cardiomyocyte production during zebrafish heart development and regeneration.
These findings point to complexity of regulation by edn1 and hand2 at the earliest stages of pharyngeal arch development, in which control of growth and morphogenesis can be genetically separated.
Title: edn1 and hand2 Interact in early regulation of pharyngeal arch outgrowth during zebrafish development.
Data indicate that mouse and zebrafish hand2 enhancers both drive transgene expression in the pharyngeal arches.
Title: Identification and characterization of the zebrafish pharyngeal arch-specific enhancer for the basic helix-loop-helix transcription factor Hand2.
reduction of fn1 function enables rescue of cardiac fusion in hand2 mutants
Title: Hand2 ensures an appropriate environment for cardiac fusion by limiting Fibronectin function.
Our study reveals an unexpected role for Hand2, a key regulator of cell specification and differentiation, in modulating ECM remodeling during organogenesis
Title: Hand2 regulates extracellular matrix remodeling essential for gut-looping morphogenesis in zebrafish.
the expression and function of hand2 and dlx3b/4b/5a genes specify major patterning domains along the dorsoventral axis of zebrafish pharyngeal arches
Title: hand2 and Dlx genes specify dorsal, intermediate and ventral domains within zebrafish pharyngeal arches.

Submit: New GeneRIF Correction See all GeneRIFs (15)

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cardiac muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardioblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardiocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardiogenic plate morphogenesis	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within determination of intestine left/right asymmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic heart tube formation	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within embryonic pectoral fin morphogenesis	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within embryonic viscerocranium morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic viscerocranium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heart looping	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within heart morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within noradrenergic neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within polarized epithelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within proepicardium development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sympathetic nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within thyroid gland development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: heart- and neural crest derivatives-expressed protein 2

Names: deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2; hands off; heart and neural crest derivatives expressed transcript 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131626.3 → NP_571701.3 heart- and neural crest derivatives-expressed protein 2

Status: VALIDATED

Source sequence(s)

BX000460

UniProtKB/Swiss-Prot

P57102

UniProtKB/TrEMBL

A0A8M1PCG1, A2BDM6

Related

ENSDARP00000022921.6, ENSDART00000020409.8

Conserved Domains (1) summary

pfam00010
Location:88 → 139

HLH; Helix-loop-helix DNA-binding domain