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PVR PVR cell adhesion molecule [ Homo sapiens (human) ]

Gene ID: 5817, updated on 5-Mar-2024

Summary

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Official Symbol
PVRprovided by HGNC
Official Full Name
PVR cell adhesion moleculeprovided by HGNC
Primary source
HGNC:HGNC:9705
See related
Ensembl:ENSG00000073008 MIM:173850; AllianceGenome:HGNC:9705
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PVS; HVED; CD155; NECL5; TAGE4; Necl-5
Summary
The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Expression
Ubiquitous expression in adrenal (RPKM 7.2), placenta (RPKM 6.6) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
19q13.31
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (44643910..44666162)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (47468632..47490944)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (45147210..45169430)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene CEA cell adhesion molecule 22, pseudogene Neighboring gene MPRA-validated peak3502 silencer Neighboring gene Sharpr-MPRA regulatory region 3461 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45081555-45082086 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:45092773-45093272 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:45097005-45097830 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45099482-45100306 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45118285-45118786 Neighboring gene immunoglobulin superfamily member 23 Neighboring gene Sharpr-MPRA regulatory region 2639 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10734 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14764 Neighboring gene MPRA-validated peak3503 silencer Neighboring gene microRNA 4531 Neighboring gene CEA cell adhesion molecule 19 Neighboring gene uncharacterized LOC107985306 Neighboring gene Sharpr-MPRA regulatory region 3873 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45192479-45192980 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45192981-45193480 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14765 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45199988-45200593 Neighboring gene CEACAM16, CEACAM19 and PVR antisense RNA 1 Neighboring gene CEA cell adhesion molecule 16, tectorial membrane component

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. CD155 in tumor progression and targeted therapy. Zhan M, et al. Cancer Lett, 2022 Oct 1. PMID 35870689
  2. CD155/SRC complex promotes hepatocellular carcinoma progression via inhibiting the p38 MAPK signalling pathway and correlates with poor prognosis. Jin AL, et al. Clin Transl Med, 2022 Apr. PMID 35384345, Free PMC Article
  3. CD155 expression impairs anti-PD1 therapy response in non-small cell lung cancer. Jiang C, et al. Clin Exp Immunol, 2022 Jun 11. PMID 35262683, Free PMC Article
  4. Immune checkpoint CD155 promoter methylation profiling reveals cancer-associated behaviors within breast neoplasia. Triki H, et al. Cancer Immunol Immunother, 2022 May. PMID 34608548
  5. CD155: A Key Receptor Playing Diversified Roles. Nandi SS, et al. Curr Mol Med, 2022. PMID 34514998

See all (174) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PITPNC1 Suppress CD8[+] T cell immune function and promote radioresistance in rectal cancer by modulating FASN/CD155.
    Title: PITPNC1 Suppress CD8(+) T cell immune function and promote radioresistance in rectal cancer by modulating FASN/CD155.
  2. ADAR-mediated RNA editing regulates PVR immune checkpoint in colorectal cancer.
    Title: ADAR-mediated RNA editing regulates PVR immune checkpoint in colorectal cancer.
  3. The immune checkpoint TIGIT/CD155 promotes the exhaustion of CD8 + T cells in TNBC through glucose metabolic reprogramming mediated by PI3K/AKT/mTOR signaling.
    Title: The immune checkpoint TIGIT/CD155 promotes the exhaustion of CD8 + T cells in TNBC through glucose metabolic reprogramming mediated by PI3K/AKT/mTOR signaling.
  4. Brain metastasis-associated fibroblasts secrete fucosylated PVR/CD155 that induces breast cancer invasion.
    Title: Brain metastasis-associated fibroblasts secrete fucosylated PVR/CD155 that induces breast cancer invasion.
  5. MicroRNA-326 negatively regulates CD155 expression in lung adenocarcinoma.
    Title: MicroRNA-326 negatively regulates CD155 expression in lung adenocarcinoma.
  6. CD155 Is a Potential Biomarker in Basal Cell Carcinoma.
    Title: CD155 Is a Potential Biomarker in Basal Cell Carcinoma.
  7. CD155 and its receptors in cancer immune escape and immunotherapy.
    Title: CD155 and its receptors in cancer immune escape and immunotherapy.
  8. CD155 and Its Receptors as Targets for Cancer Therapy.
    Title: CD155 and Its Receptors as Targets for Cancer Therapy.
  9. Upregulation of the CD155-CD226 Axis Is Associated With Muscle Inflammation and Disease Severity in Idiopathic Inflammatory Myopathies.
    Title: Upregulation of the CD155-CD226 Axis Is Associated With Muscle Inflammation and Disease Severity in Idiopathic Inflammatory Myopathies.
  10. Single-cell RNA sequencing highlights the role of PVR/PVRL2 in the immunosuppressive tumour microenvironment in hepatocellular carcinoma.
    Title: Single-cell RNA sequencing highlights the role of PVR/PVRL2 in the immunosuppressive tumour microenvironment in hepatocellular carcinoma.
Submit: New GeneRIF Correction See all GeneRIFs (115)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
EBI GWAS Catalog
Overrepresentation of glutamate signaling in Alzheimer's disease: network-based pathway enrichment using meta-analysis of genome-wide association studies.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 (SF2) Nef downregulates PVR; downregulation is dependent upon the SH3 binding domain in Nef in A3.01 T cells and HeLa TZM-bl cells PubMed
nef HIV-1 downregulates PVR on cell surface in a Nef-dependent manner. HIV-1 Vpu contributes to the activity of Nef on surface PVR downregulation PubMed
nef The Nef proteins from HIV-1 M NL4-3, SIVcpz EK505, and SIVgor CP2139 but not from SIVgsn 166, HIV-1 N CK1.62, and P RBF168, are capable of inducing cell surface downregulation of CD155 PubMed
nef HIV-1 Vpu and Nef are both required to alter the subcellular localization of CD155 in perinuclear compartments and thus interfere with the efficient transport of CD155 to the cell surface PubMed
nef NK-cell mediated lysis of HIV-1-infected cells via the interaction between DNAM1 and PVR is reduced by HIV-1 Nef PubMed
Vpr vpr HIV-1 Vpr upregulates PVR expression during HIV-1 infection in CD4+ T-cells PubMed
vpr HIV-1 Vpr-mediated upregulation of PVR (CD155) requires the interaction of Vpr with the DDB1-Cul4A E3 ligase and induction of ATR-mediated DNA damage repair and G2 arrest PubMed
Vpu vpu The Vpu proteins from HIV-1 M NL4-3 and SIVgor CP2139 but not from SIVgsn 166, SIVcpz EK505, HIV-1 N CK1.62, and P RBF168, are capable of inducing cell surface downregulation of CD155 PubMed
vpu HIV-1 Vpu and Nef are both required to alter the subcellular localization of CD155 in perinuclear compartments, and thus interfere with the efficient transport of CD155 to the cell surface PubMed
vpu The transmembrane domain of HIV-1 Vpu, particularly A10, A14, and A18, is required for cell surface downregulation of CD155, while the CK-2 phosphorylation sites and the second alpha-helix in the cytoplasmic domain are dispensable PubMed
vpu HIV-1 Vpu contributes to the activity of Nef on surface PVR downregulation PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ25946

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cell adhesion molecule binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables virus receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of natural killer cell mediated cytotoxicity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in susceptibility to T cell mediated cytotoxicity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in susceptibility to natural killer cell mediated cytotoxicity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in symbiont entry into host cell IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
located_in extracellular space TAS
Traceable Author Statement
more info
 PubMed 
located_in focal adhesion HDA PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
poliovirus receptor
Names
nectin-like protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008781.2 RefSeqGene

    Range
    5113..27365
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001135768.3 → NP_001129240.1  poliovirus receptor isoform beta precursor

    See identical proteins and their annotated locations for NP_001129240.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (beta) lacks an internal segment including the putative transmembrane domain, compared to isoform alpha, resulting in its secretion into serum and cerebrospinal fluid.
    Source sequence(s)
    AC243964, AK300349
    Consensus CDS
    CCDS46105.1
    UniProtKB/Swiss-Prot
    B4DTS9, P15151, P15152, Q15267, Q15268, Q96BJ1
    Related
    ENSP00000385344.3, ENST00000403059.8
    Conserved Domains (3) summary
    cd05718
    Location:43 → 142
    Ig1_PVR_like; First immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155) and similar proteins
    cd07703
    Location:145 → 240
    Ig2_Nectin-2_like; Second immunoglobulin (Ig) domain of nectin-2 (also known as poliovirus receptor related protein 2 or CD112) and similar proteins
    smart00410
    Location:34 → 141
    IG_like; Immunoglobulin like

  2. NM_001135769.3 → NP_001129241.1  poliovirus receptor isoform gamma precursor

    See identical proteins and their annotated locations for NP_001129241.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (gamma) lacks an internal segment including the putative transmembrane domain, compared to isoform alpha, resulting in its secretion into serum and cerebrospinal fluid.
    Source sequence(s)
    AC243964, AK300349
    Consensus CDS
    CCDS46106.1
    UniProtKB/Swiss-Prot
    B4DTS9, P15151, P15152, Q15267, Q15268, Q96BJ1
    Related
    ENSP00000340870.3, ENST00000344956.8
    Conserved Domains (3) summary
    cd05718
    Location:43 → 142
    Ig1_PVR_like; First immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155) and similar proteins
    cd07703
    Location:145 → 240
    Ig2_Nectin-2_like; Second immunoglobulin (Ig) domain of nectin-2 (also known as poliovirus receptor related protein 2 or CD112) and similar proteins
    smart00410
    Location:34 → 141
    IG_like; Immunoglobulin like

  3. NM_001135770.4 → NP_001129242.2  poliovirus receptor isoform delta precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has an alternate 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (delta), also known as H20B, has a shorter and distinct C-terminus, compared to isoform alpha.
    Source sequence(s)
    AC243964, DC400059, M24406
    Consensus CDS
    CCDS46107.1
    UniProtKB/Swiss-Prot
    B4DTS9, P15151, P15152, Q15267, Q15268, Q96BJ1
    UniProtKB/TrEMBL
    A0A0A0MSA9, A8K4I1
    Related
    ENSP00000383907.3, ENST00000406449.8
    Conserved Domains (3) summary
    cd05718
    Location:43 → 142
    Ig1_PVR_like; First immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155) and similar proteins
    cd07703
    Location:145 → 240
    Ig2_Nectin-2_like; Second immunoglobulin (Ig) domain of nectin-2 (also known as poliovirus receptor related protein 2 or CD112) and similar proteins
    smart00410
    Location:34 → 141
    IG_like; Immunoglobulin like

  4. NM_006505.5 → NP_006496.4  poliovirus receptor isoform alpha precursor

    See identical proteins and their annotated locations for NP_006496.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (alpha), also known as H20A.
    Source sequence(s)
    AC243964, AK290946, AK300349
    Consensus CDS
    CCDS12640.1
    UniProtKB/Swiss-Prot
    B4DTS9, P15151, P15152, Q15267, Q15268, Q96BJ1
    UniProtKB/TrEMBL
    A0A0C4DG49, A8K4I1
    Related
    ENSP00000402060.2, ENST00000425690.8
    Conserved Domains (2) summary
    cd05718
    Location:43 → 142
    Ig1_PVR_like; First immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155) and similar proteins
    cd07703
    Location:145 → 240
    Ig2_Nectin-2_like; Second immunoglobulin (Ig) domain of nectin-2 (also known as poliovirus receptor related protein 2 or CD112) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    44643910..44666162
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    47468632..47490944
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P15151.2 GenPept UniProtKB/Swiss-Prot:P15151

Gene LinkOut

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