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Trem1 triggering receptor expressed on myeloid cells 1 [ Mus musculus (house mouse) ]

Gene ID: 58217, updated on 12-Sep-2021

Summary

Official Symbol
Trem1provided by MGI
Official Full Name
triggering receptor expressed on myeloid cells 1provided by MGI
Primary source
MGI:MGI:1930005
See related
Ensembl:ENSMUSG00000042265
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Expression
Biased expression in testis adult (RPKM 1.2), liver E18 (RPKM 1.1) and 5 other tissues See more
Orthologs
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Genomic context

See Trem1 in Genome Data Viewer
Location:
17; 17 C
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (48539763..48553955)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (48232713..48246927)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (48371922..48386091)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9830107B12 gene Neighboring gene RIKEN cDNA A530064D06 gene Neighboring gene predicted gene, 52308 Neighboring gene Ewing sarcoma breakpoint region 1 pseudogene Neighboring gene predicted gene, 52307 Neighboring gene triggering receptor expressed on myeloid cells 3 Neighboring gene triggering receptor expressed on myeloid cells-like 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in acute inflammatory response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in chemokine production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within chemokine production IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cytokine production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cytokine production involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cytokine production involved in immune response IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in neutrophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within neutrophil chemotaxis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neutrophil extravasation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in neutrophil-mediated killing of gram-negative bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within neutrophil-mediated killing of gram-negative bacterium IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of macrophage chemotaxis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
triggering receptor expressed on myeloid cells 1
Names
triggering receptor expressed in monocytes 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347399.1NP_001334328.1  triggering receptor expressed on myeloid cells 1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC241601
    Consensus CDS
    CCDS84319.1
    UniProtKB/TrEMBL
    Q14DT9
    Related
    ENSMUSP00000108877.4, ENSMUST00000113251.10
  2. NM_021406.5NP_067381.1  triggering receptor expressed on myeloid cells 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_067381.1

    Status: VALIDATED

    Source sequence(s)
    AC241601, AK089439
    Consensus CDS
    CCDS28860.1
    UniProtKB/Swiss-Prot
    Q9JKE2
    Related
    ENSMUSP00000038636.7, ENSMUST00000048782.7
    Conserved Domains (2) summary
    smart00410
    Location:32133
    IG_like; Immunoglobulin like
    pfam07686
    Location:32134
    V-set; Immunoglobulin V-set domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    48539763..48553955
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524729.5XP_006524792.1  triggering receptor expressed on myeloid cells 1 isoform X3

    Conserved Domains (1) summary
    pfam07686
    Location:32134
    V-set; Immunoglobulin V-set domain
  2. XM_036160714.1XP_036016607.1  triggering receptor expressed on myeloid cells 1 isoform X1

    Conserved Domains (2) summary
    cd00096
    Location:2833
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:25132
    Ig; Immunoglobulin domain
  3. XM_006524728.4XP_006524791.1  triggering receptor expressed on myeloid cells 1 isoform X2

    See identical proteins and their annotated locations for XP_006524791.1

    Conserved Domains (1) summary
    pfam07686
    Location:189
    V-set; Immunoglobulin V-set domain
  4. XM_006524726.5XP_006524789.1  triggering receptor expressed on myeloid cells 1 isoform X2

    See identical proteins and their annotated locations for XP_006524789.1

    Conserved Domains (1) summary
    pfam07686
    Location:189
    V-set; Immunoglobulin V-set domain
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