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Trem3 triggering receptor expressed on myeloid cells 3 [ Mus musculus (house mouse) ]

Gene ID: 58218, updated on 23-Jun-2021

Summary

Official Symbol
Trem3provided by MGI
Official Full Name
triggering receptor expressed on myeloid cells 3provided by MGI
Primary source
MGI:MGI:1930003
See related
Ensembl:ENSMUSG00000041754
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TREM-3; BB134760
Summary
The protein encoded by this gene is part of the immunoglobulin and lectin-like superfamily and is thought to function as part of the innate immune system. This gene forms part of a cluster of genes on mouse chromosome 17 thought to be involved in innate immunity. This protein has been reported to associate with the adaptor protein Dap-12 to form a receptor signaling complex that activates myeloid cells. [provided by RefSeq, Jan 2013]
Expression
Biased expression in liver E18 (RPKM 5.6), liver E14 (RPKM 1.2) and 3 other tissues See more
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Genomic context

See Trem3 in Genome Data Viewer
Location:
17; 17 C
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (48554707..48565876)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (48247677..48258848)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (48386944..48398207)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A530064D06 gene Neighboring gene predicted gene, 52308 Neighboring gene triggering receptor expressed on myeloid cells 1 Neighboring gene Ewing sarcoma breakpoint region 1 pseudogene Neighboring gene predicted gene, 52307 Neighboring gene triggering receptor expressed on myeloid cells-like 4 Neighboring gene triggering receptor expressed on myeloid cells-like 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NOT enables lipopolysaccharide binding IDA
Inferred from Direct Assay
more info
PubMed 
NOT enables lipoteichoic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
NOT enables peptidoglycan binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
triggering receptor expressed on myeloid cells 3
Names
triggering receptor expressed on monocytes 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021407.3NP_067382.1  triggering receptor expressed on myeloid cells 3 precursor

    See identical proteins and their annotated locations for NP_067382.1

    Status: REVIEWED

    Source sequence(s)
    AC241601, AK079407, BY594056
    Consensus CDS
    CCDS28861.1
    UniProtKB/TrEMBL
    Q9JKE1
    Related
    ENSMUSP00000044478.6, ENSMUST00000048065.6
    Conserved Domains (1) summary
    cl11960
    Location:30112
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    48554707..48565876
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317592.3XP_017173081.1  triggering receptor expressed on myeloid cells 3 isoform X1

    Conserved Domains (1) summary
    cl11960
    Location:370
    Ig; Immunoglobulin domain
  2. XM_006524731.3XP_006524794.1  triggering receptor expressed on myeloid cells 3 isoform X1

    Conserved Domains (1) summary
    cl11960
    Location:370
    Ig; Immunoglobulin domain
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