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Trem3 triggering receptor expressed on myeloid cells 3 [ Mus musculus (house mouse) ]

Gene ID: 58218, updated on 8-Feb-2024

Summary

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Official Symbol
Trem3provided by MGI
Official Full Name
triggering receptor expressed on myeloid cells 3provided by MGI
Primary source
MGI:MGI:1930003
See related
Ensembl:ENSMUSG00000041754 AllianceGenome:MGI:1930003
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TREM-3
Summary
The protein encoded by this gene is part of the immunoglobulin and lectin-like superfamily and is thought to function as part of the innate immune system. This gene forms part of a cluster of genes on mouse chromosome 17 thought to be involved in innate immunity. This protein has been reported to associate with the adaptor protein Dap-12 to form a receptor signaling complex that activates myeloid cells. [provided by RefSeq, Jan 2013]
Expression
Biased expression in liver E18 (RPKM 5.6), liver E14 (RPKM 1.2) and 3 other tissues See more
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Genomic context

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Location:
17 C; 17 23.99 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (48554707..48565876)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (48247677..48258848)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A530064D06 gene Neighboring gene STARR-seq mESC enhancer starr_42746 Neighboring gene STARR-seq mESC enhancer starr_42747 Neighboring gene predicted gene, 52308 Neighboring gene triggering receptor expressed on myeloid cells 1 Neighboring gene Ewing sarcoma breakpoint region 1 pseudogene Neighboring gene predicted gene, 52307 Neighboring gene triggering receptor expressed on myeloid cells-like 4 Neighboring gene STARR-positive B cell enhancer ABC_E9957 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:48439578-48439845 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:48440299-48440452 Neighboring gene triggering receptor expressed on myeloid cells-like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Periodontal inflammation and bone loss in aged mice. Liang S, et al. J Periodontal Res, 2010 Aug. PMID 20337897, Free PMC Article
  2. Regulation of TREM expression in hepatic macrophages and endothelial cells during acute endotoxemia. Chen LC, et al. Exp Mol Pathol, 2008 Apr. PMID 18222421, Free PMC Article
  3. Reduced Uterine Tissue Damage during Chlamydia muridarum Infection in TREM-1,3-Deficient Mice. McQueen BE, et al. Infect Immun, 2021 Sep 16. PMID 34125599, Free PMC Article
  4. Role of triggering receptor expressed on myeloid cells-1/3 in Klebsiella-derived pneumosepsis. Hommes TJ, et al. Am J Respir Cell Mol Biol, 2015 Nov. PMID 25860078
  5. Role of TREM1-DAP12 in renal inflammation during obstructive nephropathy. Tammaro A, et al. PLoS One, 2013. PMID 24358193, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Reduced Uterine Tissue Damage during Chlamydia muridarum Infection in TREM-1,3-Deficient Mice.
    Title: Reduced Uterine Tissue Damage during Chlamydia muridarum Infection in TREM-1,3-Deficient Mice.
  2. TREM-1/TREM-3 macrophage expression improved host defense against Klebsiella-derived pneumosepsis, whereas TREM-2 did not have a role.
    Title: Role of triggering receptor expressed on myeloid cells-1/3 in Klebsiella-derived pneumosepsis.
  3. Like TREM-1 and TREM-2, TREM-3 signals through DAP12.
    Title: Characterization of TREM-3, an activating receptor on mouse macrophages: definition of a family of single Ig domain receptors on mouse chromosome 17.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NOT enables lipopolysaccharide binding IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables lipoteichoic acid binding IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables peptidoglycan binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in chemokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within chemokine production IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cytokine production IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cytokine production involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cytokine production involved in immune response IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in neutrophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neutrophil chemotaxis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within neutrophil extravasation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in neutrophil-mediated killing of gram-negative bacterium IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neutrophil-mediated killing of gram-negative bacterium IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of innate immune response IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
triggering receptor expressed on myeloid cells 3
Names
triggering receptor expressed on monocytes 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021407.3 → NP_067382.1  triggering receptor expressed on myeloid cells 3 precursor

    See identical proteins and their annotated locations for NP_067382.1

    Status: REVIEWED

    Source sequence(s)
    AC241601, AK079407, BY594056
    Consensus CDS
    CCDS28861.1
    UniProtKB/Swiss-Prot
    Q9JKE1
    Related
    ENSMUSP00000044478.6, ENSMUST00000048065.6
    Conserved Domains (1) summary
    cl11960
    Location:30 → 112
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    48554707..48565876
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317592.3 → XP_017173081.1  triggering receptor expressed on myeloid cells 3 isoform X1

    Conserved Domains (1) summary
    cl11960
    Location:3 → 70
    Ig; Immunoglobulin domain

  2. XM_006524731.3 → XP_006524794.1  triggering receptor expressed on myeloid cells 3 isoform X1

    Conserved Domains (1) summary
    cl11960
    Location:3 → 70
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JKE1.1 GenPept UniProtKB/Swiss-Prot:Q9JKE1

Gene LinkOut

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